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LYRA

LYRA THERAPEUTICS INC
LYRA

Delisted

LYRA was delisted on the 16th of March, 2026.

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33 hedge funds and large institutions have $22.4M invested in LYRA THERAPEUTICS INC in 2021 Q4 according to their latest regulatory filings, with 7 funds opening new positions, 6 increasing their positions, 11 reducing their positions, and 8 closing their positions.

New
Increased
Maintained
Reduced
Closed

0.24% less ownership

Funds ownership: 1.03% → 0.79% (-0.24%)

6% less funds holding

Funds holding: 35 → 33 (-2)

13% less first-time investments, than exits

New positions opened: 7 | Existing positions closed: 8

45% less repeat investments, than reductions

Existing positions increased: 6 | Existing positions reduced: 11

63% less capital invested

Capital invested by funds: $60.8M → $22.4M (-$38.5M)

100% less funds holding in top 10

Funds holding in top 10: 1 → 0 (-1)

Holders
33
Holders Change
-2
Holders Change %
-5.71%
% of All Funds
0.51%
Holding in Top 10
–
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-100%
% of All Funds
–
New
7
Increased
6
Reduced
11
Closed
8
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

Rank Fund Capital Flow
1
CC
Clearline Capital
New York
+$417K
2
Renaissance Technologies
Renaissance Technologies
New York
+$334K
3
PCM
Pentwater Capital Management
Florida
+$253K
4
Millennium Management
Millennium Management
New York
+$224K
5
Citadel Advisors
Citadel Advisors
Florida
+$85.1K

Top Sellers

Rank Fund Capital Flow
1
SCM
Soleus Capital Management
Connecticut
-$1.32M
2
ACH
ArrowMark Colorado Holdings
Colorado
-$1.27M
3
PGM
Parian Global Management
New York
-$1.11M
4
Deutsche Bank
Deutsche Bank
Germany
-$697K
5
Bank of America
Bank of America
North Carolina
-$171K
Name Holding Trade Value Shares
Change 		Change in
Stake
JP Morgan Chase
26
JP Morgan Chase
New York
$4K +$5.14K +16 +1,600%
LWANC
27
Laurel Wealth Advisors (North Carolina)
North Carolina
$2K – – –
US Bancorp
28
US Bancorp
Minnesota
$2K – – –
Wells Fargo
29
Wells Fargo
California
$2K – – –
CA
30
CoreCap Advisors
Michigan
$1K +$964 +3 New
Koshinski Asset Management
31
Koshinski Asset Management
Illinois
$872 – – –
TWC
32
TD Waterhouse Canada
Ontario, Canada
$870 +$1.28K +4 New
ACH
33
ArrowMark Colorado Holdings
Colorado
– -$1.27M -2,784 Closed
PGM
34
Parian Global Management
New York
– -$1.11M -2,426 Closed
Deutsche Bank
35
Deutsche Bank
Germany
– -$697K -1,527 Closed
E
36
Ergoteles
New York
– -$149K -325 Closed
Marshall Wace
37
Marshall Wace
United Kingdom
– -$114K -249 Closed
TI
38
Trexquant Investment
Connecticut
– -$101K -222 Closed
CCMIC
39
Cardinal Capital Management Inc (Canada)
Manitoba, Canada
– -$6K -13 Closed
HI
40
Harbour Investments
Wisconsin
– -$2K -4 Closed
Royal Bank of Canada
41
Royal Bank of Canada
Ontario, Canada
– -$1.28K -4 -67%
1
2

LYRA Hedge Fund Activity: Q4 2021 in Review

33 of the 6,499 institutional investors tracked by Wall St. Rank reported a position in LYRA THERAPEUTICS INC (LYRA) for Q4 2021, worth a combined $22.4M — down 63% from $60.8M a quarter earlier.

Sellers outnumbered buyers: 8 funds closed out of LYRA and 7 opened new positions — a net loss of 1 holder — while 11 trimmed existing stakes and 6 added.

The largest buyer was Clearline Capital, opening a new position worth an estimated $417K. The largest seller was Soleus Capital Management, cutting an estimated $1.32M.

  • 33 institutional investors held LYRA THERAPEUTICS INC (LYRA) as of Q4 2021, down from 35 in Q3 2021.
  • Funds reported $22.4M of LYRA THERAPEUTICS INC stock for Q4 2021, down 63% quarter-over-quarter.
  • 7 funds opened new LYRA THERAPEUTICS INC positions in Q4 2021 and 8 closed out, a net change of -1 holder.
  • The largest LYRA THERAPEUTICS INC buyer in Q4 2021 was Clearline Capital, an estimated $417K added.
  • The largest LYRA THERAPEUTICS INC seller in Q4 2021 was Soleus Capital Management, an estimated $1.32M sold.

Based on aggregated 13F filings for Q4 2021.