|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$1.42B
|
+$55.8M
|
+649,306
|
+6%
|
|
|
2
|
Baker Bros. Advisors
New York
|
$993M
|
–
|
–
|
–
|
|
|
3
|
Avoro Capital Advisors
New York
|
$857M
|
–
|
–
|
–
|
|
|
4
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$816M
|
+$90.4M
|
+1,052,133
|
+17%
|
|
|
5
|
T. Rowe Price Investment Management
Baltimore,
Maryland
|
$718M
|
+$68.1M
|
+792,264
|
+14%
|
|
|
6
|
|
$635M
|
+$41M
|
+477,334
|
+9%
|
|
|
7
|
BVF Inc
San Francisco,
California
|
$444M
|
-$140M
|
-1,630,658
|
-30%
|
|
|
8
|
Wellington Management Group
Boston,
Massachusetts
|
$421M
|
-$18.4M
|
-214,659
|
-6%
|
|
|
9
|
Vanguard Portfolio Management
Malvern,
Pennsylvania
|
$343M
|
+$10.2M
|
+118,137
|
+4%
|
|
|
10
|
Siren LLC
Greenwich,
Connecticut
|
$337M
|
-$21.6M
|
-251,000
|
-8%
|
|
|
11
|
Vanguard Capital Management
Malvern,
Pennsylvania
|
$336M
|
+$4.47M
|
+52,054
|
+2%
|
|
|
12
|
Atlas Venture Life Science Advisors
Cambridge,
Massachusetts
|
$327M
|
-$149M
|
-1,730,467
|
-38%
|
|
|
13
|
State Street
Boston,
Massachusetts
|
$314M
|
+$29.9M
|
+347,459
|
+15%
|
|
|
14
|
Geode Capital Management
Boston,
Massachusetts
|
$208M
|
+$14.7M
|
+170,981
|
+10%
|
|
|
15
|
Capital Research Global Investors
Los Angeles,
California
|
$159M
|
-$24.4M
|
-284,394
|
-17%
|
|
|
16
|
|
$136M
|
+$25.7M
|
+298,924
|
+34%
|
|
|
17
|
UBS Group
Zurich,
Switzerland
|
$116M
|
-$1.38M
|
-16,075
|
-2%
|
|
|
18
|
Driehaus Capital Management
Chicago,
Illinois
|
$105M
|
-$10.7M
|
-124,350
|
-12%
|
|
|
19
|
Merck & Co
Rahway,
New Jersey
|
$88.5M
|
–
|
–
|
–
|
|
|
20
|
|
$86.8M
|
+$65.1M
|
+757,246
|
New
|
|
|
21
|
Federated Hermes
Pittsburgh,
Pennsylvania
|
$85.9M
|
+$18.3M
|
+212,718
|
+40%
|
|
|
22
|
Dimensional Fund Advisors
Austin,
Texas
|
$85.4M
|
+$13.1M
|
+152,273
|
+26%
|
|
|
23
|
Frontier Capital Management
Boston,
Massachusetts
|
$85M
|
-$1.63M
|
-18,982
|
-2%
|
|
|
24
|
|
$84.5M
|
-$11.9M
|
-139,006
|
-16%
|
|
|
25
|
AllianceBernstein
Nashville,
Tennessee
|
$81.8M
|
+$8.03M
|
+93,486
|
+11%
|
|
