|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$695M
|
+$206M
|
+3,048,963
|
+52%
|
|
|
2
|
Baker Bros. Advisors
New York
|
$674M
|
+$135M
|
+2,005,813
|
+30%
|
|
|
3
|
Avoro Capital Advisors
New York
|
$582M
|
+$76M
|
+1,124,747
|
+18%
|
|
|
4
|
Vanguard Group
Malvern,
Pennsylvania
|
$488M
|
+$57.1M
|
+845,922
|
+16%
|
|
|
5
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$479M
|
+$71.7M
|
+1,061,957
|
+21%
|
|
|
6
|
BVF Inc
San Francisco,
California
|
$428M
|
–
|
–
|
–
|
|
|
7
|
|
$389M
|
+$43.1M
|
+638,647
|
+15%
|
|
|
8
|
Atlas Venture Life Science Advisors
Cambridge,
Massachusetts
|
$363M
|
-$16M
|
-236,588
|
-5%
|
|
|
9
|
Wellington Management Group
Boston,
Massachusetts
|
$343M
|
-$52.9M
|
-782,758
|
-15%
|
|
|
10
|
Siren LLC
Greenwich,
Connecticut
|
$256M
|
-$9.54M
|
-141,320
|
-4%
|
|
|
11
|
State Street
Boston,
Massachusetts
|
$172M
|
+$12.9M
|
+190,383
|
+9%
|
|
|
12
|
Capital Research Global Investors
Los Angeles,
California
|
$121M
|
+$20.2M
|
+298,609
|
+24%
|
|
|
13
|
Geode Capital Management
Boston,
Massachusetts
|
$110M
|
+$9.5M
|
+140,623
|
+11%
|
|
|
14
|
Driehaus Capital Management
Chicago,
Illinois
|
$83.2M
|
+$8.79M
|
+130,144
|
+14%
|
|
|
15
|
AllianceBernstein
Nashville,
Tennessee
|
$74.1M
|
+$61M
|
+903,296
|
+1,852%
|
|
|
16
|
|
$71M
|
+$3.29M
|
+48,736
|
+6%
|
|
|
17
|
Merck & Co
Rahway,
New Jersey
|
$60.1M
|
–
|
–
|
–
|
|
|
18
|
Federated Hermes
Pittsburgh,
Pennsylvania
|
$59.4M
|
+$13.9M
|
+205,220
|
+37%
|
|
|
19
|
Holocene Advisors
New York
|
$59.2M
|
-$5.34M
|
-79,124
|
-9%
|
|
|
20
|
Commodore Capital
New York
|
$58.4M
|
–
|
–
|
–
|
|
|
21
|
|
$57.6M
|
+$1.95M
|
+28,862
|
+4%
|
|
|
22
|
UBS Group
Zurich,
Switzerland
|
$57.3M
|
+$5.96M
|
+88,314
|
+14%
|
|
|
23
|
Frontier Capital Management
Boston,
Massachusetts
|
$49.5M
|
+$7.96M
|
+117,900
|
+23%
|
|
|
24
|
T. Rowe Price Investment Management
Baltimore,
Maryland
|
$49M
|
+$1.25M
|
+18,524
|
+3%
|
|
|
25
|
Eventide Asset Management
Boston,
Massachusetts
|
$48.7M
|
-$1.23M
|
-18,160
|
-3%
|
|
