|
1
|
Baker Bros. Advisors
New York
|
$376M
|
–
|
–
|
–
|
|
|
2
|
Avoro Capital Advisors
New York
|
$359M
|
-$9.27M
|
-205,555
|
-3%
|
|
|
3
|
Fidelity Investments
Boston,
Massachusetts
|
$333M
|
+$20.2M
|
+447,617
|
+8%
|
|
|
4
|
BVF Inc
San Francisco,
California
|
$311M
|
–
|
–
|
–
|
|
|
5
|
Vanguard Group
Malvern,
Pennsylvania
|
$307M
|
-$8.94M
|
-198,126
|
-4%
|
|
|
6
|
Wellington Management Group
Boston,
Massachusetts
|
$294M
|
-$7.95M
|
-176,370
|
-3%
|
|
|
7
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$289M
|
-$79.5M
|
-1,761,824
|
-26%
|
|
|
8
|
Atlas Venture Life Science Advisors
Cambridge,
Massachusetts
|
$277M
|
–
|
–
|
–
|
|
|
9
|
|
$247M
|
+$9.8M
|
+217,188
|
+5%
|
|
|
10
|
Siren LLC
Greenwich,
Connecticut
|
$194M
|
–
|
–
|
–
|
|
|
11
|
State Street
Boston,
Massachusetts
|
$114M
|
+$21M
|
+465,023
|
+30%
|
|
|
12
|
Geode Capital Management
Boston,
Massachusetts
|
$72.3M
|
+$3.77M
|
+83,654
|
+7%
|
|
|
13
|
Capital Research Global Investors
Los Angeles,
California
|
$71.4M
|
–
|
–
|
–
|
|
|
14
|
Jennison Associates
New York
|
$58.2M
|
+$9.14M
|
+202,714
|
+25%
|
|
|
15
|
Driehaus Capital Management
Chicago,
Illinois
|
$53.2M
|
+$235K
|
+5,204
|
+0.6%
|
|
|
16
|
|
$48.9M
|
+$2.02M
|
+44,835
|
+5%
|
|
|
17
|
Holocene Advisors
New York
|
$47.6M
|
+$37.9M
|
+840,333
|
New
|
|
|
18
|
Merck & Co
Rahway,
New Jersey
|
$43.7M
|
–
|
–
|
–
|
|
|
19
|
Commodore Capital
New York
|
$42.5M
|
–
|
–
|
–
|
|
|
20
|
Dimensional Fund Advisors
Austin,
Texas
|
$41.4M
|
+$7.58M
|
+168,055
|
+30%
|
|
|
21
|
|
$40.3M
|
+$19.5M
|
+432,708
|
+155%
|
|
|
22
|
UBS Group
Zurich,
Switzerland
|
$36.7M
|
+$4.1M
|
+90,984
|
+16%
|
|
|
23
|
Eventide Asset Management
Boston,
Massachusetts
|
$36.5M
|
+$3.68M
|
+81,600
|
+14%
|
|
|
24
|
Alyeska Investment Group
Chicago,
Illinois
|
$34.8M
|
+$25.5M
|
+565,091
|
+1,130%
|
|
|
25
|
T. Rowe Price Investment Management
Baltimore,
Maryland
|
$34.6M
|
+$23.5M
|
+520,593
|
+574%
|
|
