|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$974M
|
+$219M
|
+2,771,376
|
+31%
|
|
|
2
|
Baker Bros. Advisors
New York
|
$721M
|
–
|
–
|
–
|
|
|
3
|
Avoro Capital Advisors
New York
|
$623M
|
–
|
–
|
–
|
|
|
4
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$505M
|
-$7.8M
|
-98,488
|
-2%
|
|
|
5
|
BVF Inc
San Francisco,
California
|
$458M
|
–
|
–
|
–
|
|
|
6
|
T. Rowe Price Investment Management
Baltimore,
Maryland
|
$455M
|
+$383M
|
+4,835,252
|
+768%
|
|
|
7
|
|
$422M
|
+$4.5M
|
+56,781
|
+1%
|
|
|
8
|
Atlas Venture Life Science Advisors
Cambridge,
Massachusetts
|
$381M
|
-$6.48M
|
-81,866
|
-2%
|
|
|
9
|
Wellington Management Group
Boston,
Massachusetts
|
$324M
|
-$41.4M
|
-523,246
|
-12%
|
|
|
10
|
Siren LLC
Greenwich,
Connecticut
|
$265M
|
-$7.92M
|
-100,000
|
-3%
|
|
|
11
|
Vanguard Capital Management
Malvern,
Pennsylvania
|
$240M
|
+$228M
|
+2,880,324
|
New
|
|
|
12
|
Vanguard Portfolio Management
Malvern,
Pennsylvania
|
$239M
|
+$228M
|
+2,874,056
|
New
|
|
|
13
|
State Street
Boston,
Massachusetts
|
$199M
|
+$14.2M
|
+179,930
|
+8%
|
|
|
14
|
Capital Research Global Investors
Los Angeles,
California
|
$139M
|
+$8.91M
|
+112,484
|
+7%
|
|
|
15
|
Geode Capital Management
Boston,
Massachusetts
|
$137M
|
+$18.1M
|
+227,961
|
+16%
|
|
|
16
|
Driehaus Capital Management
Chicago,
Illinois
|
$86.9M
|
-$2.03M
|
-25,655
|
-2%
|
|
|
17
|
UBS Group
Zurich,
Switzerland
|
$85.3M
|
+$22.7M
|
+286,820
|
+39%
|
|
|
18
|
|
$74M
|
+$11.7M
|
+148,103
|
+20%
|
|
|
19
|
|
$73M
|
-$2.9M
|
-36,626
|
-4%
|
|
|
20
|
Holocene Advisors
New York
|
$69.7M
|
+$5.98M
|
+75,550
|
+10%
|
|
|
21
|
AllianceBernstein
Nashville,
Tennessee
|
$69.1M
|
-$5.07M
|
-64,030
|
-7%
|
|
|
22
|
Merck & Co
Rahway,
New Jersey
|
$64.3M
|
–
|
–
|
–
|
|
|
23
|
Frontier Capital Management
Boston,
Massachusetts
|
$63.3M
|
+$9.81M
|
+123,891
|
+19%
|
|
|
24
|
Commodore Capital
New York
|
$62.5M
|
–
|
–
|
–
|
|
|
25
|
Eventide Asset Management
Boston,
Massachusetts
|
$52.2M
|
+$39.2K
|
+495
|
+0.1%
|
|
