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Disc Medicine

203 hedge funds and large institutions have $2.67B invested in Disc Medicine in 2026 Q1 according to their latest regulatory filings, with 48 funds opening new positions, 80 increasing their positions, 44 reducing their positions, and 38 closing their positions.

New
Increased
Maintained
Reduced
Closed

365% more call options, than puts

Call options by funds: $23.3M | Put options by funds: $5.01M

82% more repeat investments, than reductions

Existing positions increased: 80 | Existing positions reduced: 44

26% more first-time investments, than exits

New positions opened: 48 | Existing positions closed: 38

8.37% more ownership

Funds ownership: 101.43%109.8% (+8.4%)

4% more funds holding

Funds holding: 196203 (+7)

12% less capital invested

Capital invested by funds: $3.04B → $2.67B (-$369M)

45% less funds holding in top 10

Funds holding in top 10: 116 (-5)

Holders
203
Holders Change
+7
Holders Change %
+3.57%
% of All Funds
2.5%
Holding in Top 10
6
Holding in Top 10 Change
-5
Holding in Top 10 Change %
-45.45%
% of All Funds
0.07%
New
48
Increased
80
Reduced
44
Closed
38
Calls
$23.3M
Puts
$5.01M
Net Calls
+$18.3M
Net Calls Change
+$24.9M
Name Holding Trade Value Shares
Change
Change in
Stake
OM
26
Opaleye Management
Massachusetts
$26.9M +$15.3M +221,000 +111%
PAI
27
Palo Alto Investors
California
$25.7M +$5.85M +84,263 +27%
EAM
28
Eventide Asset Management
Massachusetts
$25.3M +$12.5K +180 +0%
Dimensional Fund Advisors
29
Dimensional Fund Advisors
Texas
$25.2M +$11.9M +170,872 +76%
Pictet Asset Management
30
Pictet Asset Management
Switzerland
$24.7M -$511K -7,369 -2%
Aberdeen Group
31
Aberdeen Group
United Kingdom
$24M +$9.8M +141,256 +60%
FCMV
32
Foresite Capital Management V
California
$23.9M +$5.2M +75,000 +25%
BBA
33
Baker Bros. Advisors
New York
$22.4M +$875K +12,607 +4%
Loomis, Sayles & Company
34
Loomis, Sayles & Company
Massachusetts
$20.3M +$2.42M +34,813 +12%
CC
35
Checkpoint Capital
California
$18.3M -$11.5M -166,331 -37%
OCA
36
Octagon Capital Advisors
New York
$17.3M +$18.7M +270,000 New
Charles Schwab
37
Charles Schwab
California
$16.1M +$288K +4,156 +2%
VPM
38
Vanguard Portfolio Management
Pennsylvania
$15.8M +$17.2M +247,338 New
Northern Trust
39
Northern Trust
Illinois
$15.8M +$1.33M +19,125 +8%
VFT
40
Vanguard Fiduciary Trust
Pennsylvania
$13.9M +$15.1M +217,436 New
Bank of New York Mellon
41
Bank of New York Mellon
New York
$13.1M +$9.53M +137,261 +203%
SCM
42
Silverarc Capital Management
Massachusetts
$12.5M +$13.6M +196,028 New
Ensign Peak Advisors
43
Ensign Peak Advisors
Utah
$12.2M +$1M +14,437 +8%
IHAM
44
Integral Health Asset Management
New York
$10.9M +$11.8M +170,000 New
Bank of America
45
Bank of America
North Carolina
$10.7M +$2.14M +30,789 +23%
BCLSI
46
Bain Capital Life Sciences Investors
Massachusetts
$9.03M +$9.8M +141,234 New
BNP Paribas Financial Markets
47
BNP Paribas Financial Markets
France
$8.17M +$388K +5,584 +5%
Alyeska Investment Group
48
Alyeska Investment Group
Illinois
$7.99M +$5.2M +75,000 +150%
CCM
49
Catalio Capital Management
New York
$7.86M +$871K +12,551 +11%
UBS AM
50
UBS AM
Illinois
$7.09M -$240K -3,461 -3%