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First Trust NYSE Arca Biotechnology Index Fund

279 hedge funds and large institutions have $712M invested in First Trust NYSE Arca Biotechnology Index Fund in 2025 Q4 according to their latest regulatory filings, with 49 funds opening new positions, 78 increasing their positions, 80 reducing their positions, and 21 closing their positions.

New
Increased
Maintained
Reduced
Closed

147% more call options, than puts

Call options by funds: $661K | Put options by funds: $268K

133% more first-time investments, than exits

New positions opened: 49 | Existing positions closed: 21

30% more capital invested

Capital invested by funds: $546M → $712M (+$166M)

10% more funds holding

Funds holding: 253279 (+26)

3.55% more ownership

Funds ownership: 49.91%53.46% (+3.6%)

3% less repeat investments, than reductions

Existing positions increased: 78 | Existing positions reduced: 80

Holders
279
Holders Change
+26
Holders Change %
+10.28%
% of All Funds
3.37%
Holding in Top 10
1
Holding in Top 10 Change
+1
Holding in Top 10 Change %
% of All Funds
0.01%
New
49
Increased
78
Reduced
80
Closed
21
Calls
$661K
Puts
$268K
Net Calls
+$393K
Net Calls Change
-$3.25M

FBT Hedge Fund Activity: Q4 2025 in Review

279 of the 8,267 institutional investors tracked by Wall St. Rank reported a position in First Trust NYSE Arca Biotechnology Index Fund (FBT) for Q4 2025, worth a combined $712M — up 30% from $546M a quarter earlier.

Buyers outnumbered sellers: 49 funds opened new FBT positions and 21 closed out — a net gain of 28 holders — while 78 added to existing stakes and 80 trimmed.

The largest buyer was 360 Financial, opening a new position worth an estimated $14.4M. The largest seller was Integrated Wealth Concepts, cutting an estimated $5.55M.

  • 279 institutional investors held First Trust NYSE Arca Biotechnology Index Fund (FBT) as of Q4 2025, up from 253 in Q3 2025.
  • Funds reported $712M of First Trust NYSE Arca Biotechnology Index Fund stock for Q4 2025, up 30% quarter-over-quarter.
  • 49 funds opened new First Trust NYSE Arca Biotechnology Index Fund positions in Q4 2025 and 21 closed out, a net change of +28 holders.
  • The largest First Trust NYSE Arca Biotechnology Index Fund buyer in Q4 2025 was 360 Financial, an estimated $14.4M added.
  • The largest First Trust NYSE Arca Biotechnology Index Fund seller in Q4 2025 was Integrated Wealth Concepts, an estimated $5.55M sold.

Based on aggregated 13F filings for Q4 2025.