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Name Holding Trade Value Shares
Change
Change in
Stake
Fidelity Investments
1
Fidelity Investments
Massachusetts
$3.46B +$483M +824,750 +17%
T. Rowe Price Associates
2
T. Rowe Price Associates
Maryland
$3.39B -$178M -303,653 -5%
Artisan Partners
3
Artisan Partners
Wisconsin
$1.89B -$260M -443,247 -13%
Janus Henderson Group
4
Janus Henderson Group
$1.42B -$97.8M -166,849 -7%
Capital World Investors
5
Capital World Investors
California
$1.1B +$50.8M +86,687 +5%
ACA
6
Avoro Capital Advisors
New York
$762M
BlackRock
7
BlackRock
New York
$657M -$32.7M -55,866 -5%
Morgan Stanley
8
Morgan Stanley
New York
$577M +$4.56M +7,789 +0.8%
RI
9
RTW Investments
New York
$414M +$11.2M +19,067 +3%
ClearBridge Investments
10
ClearBridge Investments
New York
$387M +$23.6M +40,330 +7%
BG
11
Bellevue Group
Switzerland
$365M -$23.2M -39,645 -6%
Citadel Advisors
12
Citadel Advisors
Florida
$316M -$59.1M -100,821 -16%
T. Rowe Price Investment Management
13
T. Rowe Price Investment Management
Maryland
$300M -$166M -283,719 -37%
PBA
14
Paradigm Biocapital Advisors
New York
$296M +$546K +931 +0.2%
Wellington Management Group
15
Wellington Management Group
Massachusetts
$261M -$33.6M -57,372 -12%
Invesco
16
Invesco
Georgia
$248M -$17.3M -29,500 -7%
SEI Investments
17
SEI Investments
Pennsylvania
$225M -$8.25M -14,075 -4%
Jennison Associates
18
Jennison Associates
New York
$186M +$37.6M +64,183 +27%
D.E. Shaw & Co
19
D.E. Shaw & Co
New York
$177M +$109M +186,697 +184%
Pictet Asset Management
20
Pictet Asset Management
Switzerland
$175M -$39.2M -66,909 -19%
Bank of America
21
Bank of America
North Carolina
$159M -$45.2M -77,158 -23%
BAMCO Inc
22
BAMCO Inc
New York
$149M -$4.76M -8,126 -3%
RSCM
23
Rock Springs Capital Management
Maryland
$141M -$2.29M -3,900 -2%
JFG
24
Jefferies Financial Group
New York
$133M +$32.7M +55,752 +35%
1832 Asset Management
25
1832 Asset Management
Ontario, Canada
$127M +$34M +58,000 +39%