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Name Holding Trade Value Shares
Change
Change in
Stake
Fidelity Investments
1
Fidelity Investments
Massachusetts
$1.83B +$78.3M +211,389 +4%
T. Rowe Price Associates
2
T. Rowe Price Associates
Maryland
$1.5B -$792M -2,138,627 -34%
Artisan Partners
3
Artisan Partners
Wisconsin
$999M -$77.5M -209,217 -7%
T. Rowe Price Investment Management
4
T. Rowe Price Investment Management
Maryland
$713M +$748M +2,018,218 New
Jennison Associates
5
Jennison Associates
New York
$547M +$1.42M +3,838 +0.2%
ACA
6
Avoro Capital Advisors
New York
$447M
BG
7
Bellevue Group
Switzerland
$332M -$5.36M -14,457 -2%
BlackRock
8
BlackRock
New York
$284M +$6.7M +18,092 +2%
Capital World Investors
9
Capital World Investors
California
$261M +$225K +606 +0.1%
Janus Henderson Group
10
Janus Henderson Group
$199M -$1.46M -3,931 -0.7%
Holocene Advisors
11
Holocene Advisors
New York
$181M -$3.62M -9,769 -2%
PAMS
12
Pictet Asset Management (Switzerland)
Switzerland
$177M -$25.4M -68,609 -12%
APM
13
Avidity Partners Management
Texas
$174M -$29.9M -80,700 -14%
RI
14
RTW Investments
New York
$165M +$9.1M +24,560 +6%
Federated Hermes
15
Federated Hermes
Pennsylvania
$157M +$72.6K +196 +0%
Deutsche Bank
16
Deutsche Bank
Germany
$149M +$27.3M +73,792 +21%
BAMCO Inc
17
BAMCO Inc
New York
$147M -$1.28M -3,444 -0.8%
Lord, Abbett & Co
18
Lord, Abbett & Co
New Jersey
$133M +$30.8M +83,084 +28%
RSCM
19
Rock Springs Capital Management
Maryland
$124M
EVM
20
Eaton Vance Management
Massachusetts
$123M +$516K +1,394 +0.4%
D.E. Shaw & Co
21
D.E. Shaw & Co
New York
$116M +$72.6M +196,089 +148%
EAM
22
Eventide Asset Management
Massachusetts
$113M
BBA
23
Baker Bros. Advisors
New York
$98.9M -$311M -839,398 -75%
RG
24
Redmile Group
California
$98.9M -$39.2M -105,792 -27%
O
25
OrbiMed
New York
$95.2M +$28M +75,700 +39%