|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$248M
|
+$120M
|
+1,588,566
|
+107%
|
|
|
2
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$130M
|
+$61.7M
|
+816,429
|
+103%
|
|
|
3
|
Baker Bros. Advisors
New York
|
$77.4M
|
–
|
–
|
–
|
|
|
4
|
Adage Capital Partners
Boston,
Massachusetts
|
$76.4M
|
+$14.7M
|
+194,500
|
+26%
|
|
|
5
|
Avoro Capital Advisors
New York
|
$69.4M
|
+$4.41M
|
+58,400
|
+7%
|
|
|
6
|
Millennium Management
New York
|
$66.9M
|
+$17.9M
|
+236,662
|
+40%
|
|
|
7
|
Federated Hermes
Pittsburgh,
Pennsylvania
|
$64.4M
|
–
|
–
|
–
|
|
|
8
|
Perceptive Advisors
New York
|
$43.2M
|
–
|
–
|
–
|
|
|
9
|
|
$40.2M
|
–
|
–
|
–
|
|
|
10
|
Pictet Asset Management (UK)
London,
United Kingdom
|
$36.6M
|
-$5.62M
|
-74,419
|
-14%
|
|
|
11
|
Franklin Resources
San Mateo,
California
|
$36.4M
|
-$378K
|
-5,000
|
-1%
|
|
|
12
|
Janus Henderson Group
London,
|
$35.1M
|
-$9.76M
|
-129,163
|
-23%
|
|
|
13
|
Acuta Capital Partners
Redwood City,
California
|
$32.5M
|
+$6.1M
|
+80,821
|
+25%
|
|
|
14
|
BB Biotech
Schaffhausen,
Switzerland
|
$31.9M
|
+$30M
|
+396,819
|
New
|
|
|
15
|
VHCP Management II
New York
|
$27.9M
|
-$22.9M
|
-302,873
|
-47%
|
|
|
16
|
Jennison Associates
New York
|
$26.3M
|
+$3.02M
|
+39,925
|
+14%
|
|
|
17
|
Deerfield Management
New York
|
$25.7M
|
-$3.48M
|
-46,041
|
-13%
|
|
|
18
|
Cormorant Asset Management
Boston,
Massachusetts
|
$22.4M
|
-$866K
|
-11,464
|
-4%
|
|
|
19
|
Redmile Group
San Francisco,
California
|
$19.2M
|
+$2.92M
|
+38,600
|
+19%
|
|
|
20
|
|
$16.7M
|
+$14M
|
+185,645
|
+825%
|
|
|
21
|
Renaissance Technologies
New York
|
$14.3M
|
+$780K
|
+10,328
|
+6%
|
|
|
22
|
ArrowMark Colorado Holdings
Denver,
Colorado
|
$14.1M
|
-$2.67M
|
-35,365
|
-17%
|
|
|
23
|
Loomis, Sayles & Company
Boston,
Massachusetts
|
$13.4M
|
+$12.6M
|
+166,245
|
New
|
|
|
24
|
Kingdon Capital Management
New York
|
$13.4M
|
+$5.87M
|
+77,742
|
+88%
|
|
|
25
|
TimesSquare Capital Management
New York
|
$13.2M
|
+$12.4M
|
+163,555
|
New
|
|
