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Name Holding Trade Value Shares
Change
Change in
Stake
T. Rowe Price Associates
1
T. Rowe Price Associates
Maryland
$1.95B +$172M +590,925 +11%
Fidelity Investments
2
Fidelity Investments
Massachusetts
$1.48B +$27.2M +93,716 +2%
Artisan Partners
3
Artisan Partners
Wisconsin
$1.06B +$51.1M +175,575 +6%
ACA
4
Avoro Capital Advisors
New York
$396M +$84.3M +290,000 +30%
BBA
5
Baker Bros. Advisors
New York
$353M
Jennison Associates
6
Jennison Associates
New York
$321M +$56.1M +192,844 +23%
BG
7
Bellevue Group
Switzerland
$301M -$12.7M -43,800 -4%
Point72 Asset Management
8
Point72 Asset Management
Connecticut
$250M +$113M +387,774 +96%
Capital World Investors
9
Capital World Investors
California
$233M +$23M +79,119 +12%
BlackRock
10
BlackRock
New York
$213M -$15.6M -53,579 -7%
Janus Henderson Group
11
Janus Henderson Group
$192M +$5.38M +18,490 +3%
AG
12
Artal Group
Luxembourg
$185M +$25.4M +87,500 +18%
Holocene Advisors
13
Holocene Advisors
New York
$167M +$98.6M +338,995 +178%
RG
14
Redmile Group
California
$163M -$1.66M -5,700 -1%
PAMS
15
Pictet Asset Management (Switzerland)
Switzerland
$163M +$44.3M +152,284 +42%
BAMCO Inc
16
BAMCO Inc
New York
$158M -$18.1M -62,196 -11%
Federated Hermes
17
Federated Hermes
Pennsylvania
$145M -$11.8M -40,744 -8%
EAM
18
Eventide Asset Management
Massachusetts
$130M
RSCM
19
Rock Springs Capital Management
Maryland
$110M +$10.2M +35,000 +11%
EVM
20
Eaton Vance Management
Massachusetts
$109M +$1.75K +6 +0%
RI
21
RTW Investments
New York
$106M +$5.68M +19,531 +6%
Goldman Sachs
22
Goldman Sachs
New York
$105M +$37.4M +128,759 +63%
BI
23
BVF Inc
California
$99.7M +$29.1M +100,000 +46%
Deutsche Bank
24
Deutsche Bank
Germany
$97M +$88M +302,725 +6,287%
Ameriprise
25
Ameriprise
Minnesota
$96.6M -$16M -54,961 -15%