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Name Holding Trade Value Shares
Change
Change in
Stake
T. Rowe Price Associates
1
T. Rowe Price Associates
Maryland
$3.16B +$112M +221,984 +4%
Fidelity Investments
2
Fidelity Investments
Massachusetts
$2.6B +$640M +1,265,486 +36%
Artisan Partners
3
Artisan Partners
Wisconsin
$1.9B +$1.09M +2,164 +0.1%
Janus Henderson Group
4
Janus Henderson Group
$1.34B +$5.55M +10,975 +0.4%
Capital World Investors
5
Capital World Investors
California
$922M +$95.4M +188,755 +12%
ACA
6
Avoro Capital Advisors
New York
$671M
BlackRock
7
BlackRock
New York
$610M +$57.4M +113,525 +11%
Morgan Stanley
8
Morgan Stanley
New York
$505M +$56M +110,908 +14%
T. Rowe Price Investment Management
9
T. Rowe Price Investment Management
Maryland
$418M -$583M -1,153,140 -60%
RI
10
RTW Investments
New York
$355M
BG
11
Bellevue Group
Switzerland
$343M -$29.8M -59,045 -9%
Citadel Advisors
12
Citadel Advisors
Florida
$333M -$19.3M -38,164 -6%
ClearBridge Investments
13
ClearBridge Investments
New York
$320M -$14.1M -27,968 -5%
Wellington Management Group
14
Wellington Management Group
Massachusetts
$261M +$28.1M +55,617 +13%
PBA
15
Paradigm Biocapital Advisors
New York
$260M -$29.2M -57,765 -11%
Invesco
16
Invesco
Georgia
$235M +$117M +232,044 +115%
SEI Investments
17
SEI Investments
Pennsylvania
$206M -$429K -849 -0.2%
DTC
18
Deep Track Capital
Connecticut
$198M -$17.7M -35,000 -9%
Pictet Asset Management
19
Pictet Asset Management
Switzerland
$190M +$21.9M +43,427 +14%
Alkeon Capital Management
20
Alkeon Capital Management
New York
$187M +$22.7M +45,000 +15%
Bank of America
21
Bank of America
North Carolina
$182M +$23M +45,506 +16%
BAMCO Inc
22
BAMCO Inc
New York
$136M -$5.65M -11,174 -4%
Jennison Associates
23
Jennison Associates
New York
$129M +$772K +1,528 +0.6%
RSCM
24
Rock Springs Capital Management
Maryland
$127M +$2.15M +4,250 +2%
American Century Companies
25
American Century Companies
Missouri
$126M -$11.3M -22,454 -9%