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Name Holding Trade Value Shares
Change
Change in
Stake
T. Rowe Price Associates
1
T. Rowe Price Associates
Maryland
$1.6B +$275M +871,508 +18%
Fidelity Investments
2
Fidelity Investments
Massachusetts
$1.29B -$12.8M -40,487 -0.9%
Artisan Partners
3
Artisan Partners
Wisconsin
$791M +$171M +540,488 +23%
BBA
4
Baker Bros. Advisors
New York
$308M +$31.6M +100,000 +10%
BG
5
Bellevue Group
Switzerland
$263M +$2.91M +9,206 +1%
ACA
6
Avoro Capital Advisors
New York
$255M +$7.27M +23,000 +3%
RG
7
Redmile Group
California
$234M -$21.6M -68,462 -7%
Jennison Associates
8
Jennison Associates
New York
$198M +$95.5M +302,188 +72%
Capital World Investors
9
Capital World Investors
California
$182M +$120K +380 +0.1%
BlackRock
10
BlackRock
New York
$154M +$68.2M +215,719 +63%
LPC
11
Lone Pine Capital
Connecticut
$150M +$3.16M +10,000 +2%
Wellington Management Group
12
Wellington Management Group
Massachusetts
$143M -$31M -98,062 -16%
BAMCO Inc
13
BAMCO Inc
New York
$136M +$38.3M +121,329 +33%
Federated Hermes
14
Federated Hermes
Pennsylvania
$128M -$1.61M -5,103 -1%
Janus Henderson Group
15
Janus Henderson Group
$125M +$47.9M +151,667 +50%
AG
16
Artal Group
Luxembourg
$124M +$47.4M +150,000 +50%
American Century Companies
17
American Century Companies
Missouri
$112M +$427K +1,350 +0.3%
HA
18
HHLR Advisors
Cayman Islands
$103M -$29.9M -94,460 -20%
Ameriprise
19
Ameriprise
Minnesota
$103M -$18.8M -59,372 -14%
EVM
20
Eaton Vance Management
Massachusetts
$98.6M -$15.5M -48,889 -12%
BI
21
BVF Inc
California
$85.3M +$78.1M +247,108 +395%
RSCM
22
Rock Springs Capital Management
Maryland
$82.6M +$3.95M +12,500 +4%
Invesco
23
Invesco
Georgia
$76.1M +$10.1M +31,854 +13%
TCM
24
TimesSquare Capital Management
New York
$68M +$68.2M +215,650 +691%
EAM
25
Eventide Asset Management
Massachusetts
$58.9M +$17.1M +54,000 +34%