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Name Holding Trade Value Shares
Change
Change in
Stake
T. Rowe Price Associates
1
T. Rowe Price Associates
Maryland
$1.68B -$6.12M -19,311 -0.3%
Fidelity Investments
2
Fidelity Investments
Massachusetts
$1.35B -$63.6M -200,749 -4%
Artisan Partners
3
Artisan Partners
Wisconsin
$867M -$26M -82,111 -3%
BBA
4
Baker Bros. Advisors
New York
$338M
BG
5
Bellevue Group
Switzerland
$297M +$3.14M +9,900 +1%
ACA
6
Avoro Capital Advisors
New York
$286M
Jennison Associates
7
Jennison Associates
New York
$251M +$25.6M +80,790 +11%
BlackRock
8
BlackRock
New York
$230M +$35.5M +112,106 +17%
RG
9
Redmile Group
California
$221M -$18.9M -59,700 -8%
Wellington Management Group
10
Wellington Management Group
Massachusetts
$202M +$35M +110,349 +20%
Capital World Investors
11
Capital World Investors
California
$199M -$104K -328 -0%
AG
12
Artal Group
Luxembourg
$174M +$24.5M +77,308 +15%
BAMCO Inc
13
BAMCO Inc
New York
$166M +$778K +2,455 +0.4%
Janus Henderson Group
14
Janus Henderson Group
$158M +$7.88M +24,878 +5%
Federated Hermes
15
Federated Hermes
Pennsylvania
$131M -$372K -1,175 -0.3%
BI
16
BVF Inc
California
$111M -$90.3M -285,000 -44%
Ameriprise
17
Ameriprise
Minnesota
$110M -$1.15M -3,626 -1%
EVM
18
Eaton Vance Management
Massachusetts
$105M -$3.41M -10,768 -3%
PAMS
19
Pictet Asset Management (Switzerland)
Switzerland
$103M +$108M +341,404 New
EAM
20
Eventide Asset Management
Massachusetts
$101M
RSCM
21
Rock Springs Capital Management
Maryland
$95.1M
Point72 Asset Management
22
Point72 Asset Management
Connecticut
$86.7M +$40.7M +128,347 +81%
ClearBridge Investments
23
ClearBridge Investments
New York
$85.6M +$11.3M +35,688 +14%
American Century Companies
24
American Century Companies
Missouri
$67.8M -$58.8M -185,455 -45%
CS
25
Credit Suisse
Switzerland
$63M -$618K -1,949 -0.9%