Two Sigma Investments
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Two Sigma Investments’s Praxis Precision Medicines PRAX Stock Holding History

Two Sigma Investments’s Portfolio PRAX Stock Details PRAX Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$6.28M Buy
18,758
+1,160
+7% +$367K ﹤0.01% 1926
2026
Q1 		$5.67M Sell
17,598
-5,500
-24% -$1.7M ﹤0.01% 1861
2025
Q4 		$6.81M Buy
23,098
+17,590
+319% +$3.28M 0.01% 1424
2025
Q3 		$292K Sell
5,508
-1,001
-15% -$48.5K ﹤0.01% 3222
2025
Q2 		$274K Sell
6,509
-12,299
-65% -$468K ﹤0.01% 2824
2025
Q1 		$712K Sell
18,808
-1,258
-6% -$78.6K ﹤0.01% 2352
2024
Q4 		$1.54M Sell
20,066
-2,700
-12% -$195K ﹤0.01% 1888
2024
Q3 		$1.31M Sell
22,766
-1,200
-5% -$64.8K ﹤0.01% 1954
2024
Q2 		$991K Buy
23,966
+594
+3% +$28.1K ﹤0.01% 1988
2024
Q1 		$1.43M Buy
23,372
+13,946
+148% +$626K ﹤0.01% 1734
2023
Q4 		$210K Buy
9,426
+5,633
+149% +$101K ﹤0.01% 2818
2023
Q3 		$97.3K Buy
3,793
+2,986
+370% +$56.5K ﹤0.01% 2750
2023
Q2 		$13.9K Sell
807
-2,713
-77% -$41.5K ﹤0.01% 2935
2023
Q1 		$42.7K Sell
3,520
-15,065
-81% -$636K ﹤0.01% 2777
2022
Q4 		$663K Sell
18,585
-10,881
-37% -$339K ﹤0.01% 1897
2022
Q3 		$1M Buy
29,466
+2,557
+10% +$127K ﹤0.01% 1471
2022
Q2 		$989K Buy
26,909
+19,291
+253% +$2.06M ﹤0.01% 1547
2022
Q1 		$1.17M Sell
7,618
-2,526
-25% -$519K ﹤0.01% 1639
2021
Q4 		$3M Buy
10,144
+1,703
+20% +$499K 0.01% 1575
2021
Q3 		$2.34M Sell
8,441
-3,845
-31% -$1.04M 0.01% 1846
2021
Q2 		$3.37M Buy
+12,286
New +$4.4M 0.01% 1461

Other funds holding PRAX

JT
Jupiter Topco New York $245B AUM
Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
PA
Perceptive Advisors New York $6.66B AUM 360.84% 1-Year Est. Return
BBA
Baker Bros. Advisors New York $20B AUM 154.41% 1-Year Est. Return
OAG
Orbis Allan Gray Hamilton, Bermuda $29.1B AUM 60.8% 1-Year Est. Return
Vanguard Portfolio Management
Vanguard Portfolio Management Malvern, Pennsylvania $2.22T AUM
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
State Street
State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return
Adage Capital Partners
Adage Capital Partners Boston, Massachusetts $71.3B AUM 56.8% 1-Year Est. Return

Two Sigma Investments's PRAX Position: Q2 2026 in Review

Two Sigma Investments increased its Praxis Precision Medicines (PRAX) stake by 6.6% in Q2 2026, buying an estimated $367K and bringing the position to 18,758 shares worth $6.28M. The position accounts for ﹤0.01% of the portfolio, ranked #1926.

Two Sigma Investments first reported a position in PRAX in Q2 2021 and has held it in 21 quarters since. The position peaked at $6.81M in Q4 2025. 310 funds tracked by Wall St. Rank hold PRAX as of Q2 2026.

  • Two Sigma Investments held 18,758 shares of Praxis Precision Medicines worth $6.28M as of Q2 2026.
  • Two Sigma Investments bought 1,160 Praxis Precision Medicines shares in Q2 2026, an estimated $367K.
  • Praxis Precision Medicines made up ﹤0.01% of Two Sigma Investments's portfolio in Q2 2026, its #1926 holding.
  • Two Sigma Investments first reported a position in Praxis Precision Medicines in Q2 2021 and has held it in 21 quarters since.
  • Two Sigma Investments's Praxis Precision Medicines position peaked at $6.81M in Q4 2025.
  • 310 funds tracked by Wall St. Rank held Praxis Precision Medicines as of Q2 2026.

Based on Two Sigma Investments's 13F filing for Q2 2026, filed 14 Aug 2026.