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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
-13.26%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$4.83B
AUM Growth
-$2.02B
Cap. Flow
-$868M
Cap. Flow %
-17.97%
Top 10 Hldgs %
38.68%
Holding
126
New
2
Increased
20
Reduced
30
Closed
20

Top Buys

Rank Stock Value
1
PTGX icon
Protagonist Therapeutics
PTGX
+$61.8M
2
MASI
Masimo
MASI
+$53.3M
3
CCCC icon
C4 Therapeutics
CCCC
+$49.5M
4
CINC
CinCor Pharma, Inc. Common Stock
CINC
+$28.5M
5
TSVT
2seventy bio
TSVT
+$20.9M

Top Sells

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$423M
2
ISEE
IVERIC bio, Inc. Common Stock
ISEE
+$112M
3
APLS
Apellis Pharmaceuticals
APLS
+$85.6M
4
ITOS
iTeos Therapeutics
ITOS
+$67.7M
5
IDYA icon
IDEAYA Biosciences
IDYA
+$59.6M

Sector Composition

Rank Sector Weight
1 Healthcare 99.3%
2 Financials 0.6%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
UTRS
101
DELISTED
Minerva Surgical, Inc. Common Stock
UTRS
$747K 0.02%
8,300
– –
OMIC
102
DELISTED
Singular Genomics Systems, Inc. Common Stock
OMIC
$631K 0.01%
3,333
– –
ADVM
103
DELISTED
Adverum Biotechnologies
ADVM
$293K 0.01%
22,373
-733,109
-97% -$10.7M
ZY
104
DELISTED
Zymergen Inc. Common Stock
ZY
$202K ﹤0.01%
70,000
– –
RCOR.WS
105
DELISTED
Renovacor, Inc. Warrants, entitling the holder thereof to purchase one-half (1/2) of a share of common stock at a price of $11. 50 per whole share
RCOR.WS
$109K ﹤0.01%
350,000
– –
MSACW
106
DELISTED
Medicus Sciences Acquisition Corp. Warrant
MSACW
$14K ﹤0.01%
33,331
– –
ABUS icon
107
Arbutus Biopharma
ABUS
$915M
– –
-2,504,493
Closed -$9.74M
ARWR icon
108
Arrowhead Research
ARWR
$12.4B
– –
-346,842
Closed -$23M
BMEA icon
109
Biomea Fusion
BMEA
$91.3M
– –
-593,846
Closed -$4.42M
BOLT icon
110
Bolt Biotherapeutics
BOLT
$7.78M
– –
-6,318
Closed -$619K
CLSD
111
DELISTED
Clearside Biomedical
CLSD
– –
-253,735
Closed -$10.5M
IDYA icon
112
IDEAYA Biosciences
IDYA
$3.56B
– –
-2,520,076
Closed -$59.6M
INKT icon
113
MiNK Therapeutics
INKT
$54.6M
– –
-41,667
Closed -$1.86M
MDXG icon
114
MiMedx Group
MDXG
$633M
– –
-295,748
Closed -$1.79M
MRUS
115
DELISTED
Merus
MRUS
– –
-196,231
Closed -$6.24M
NEO icon
116
NeoGenomics
NEO
$2.13B
– –
-311,111
Closed -$10.6M
OSUR icon
117
OraSure Technologies
OSUR
$279M
– –
-1,154,380
Closed -$10M
SPY icon
118
State Street SPDR S&P 500 ETF Trust
SPY
$810B
– –
-889,739
Closed -$423M
SRPT icon
119
Sarepta Therapeutics
SRPT
$1.77B
– –
-582,265
Closed -$52.4M
TNGX icon
120
Tango Therapeutics
TNGX
$4.41B
– –
-180,819
Closed -$1.98M
WGS icon
121
GeneDx Holdings
WGS
$2.3B
– –
-12,121
Closed -$1.78M
ACHL
122
DELISTED
Achilles Therapeutics
ACHL
– –
-12,229
Closed -$61K
VINC
123
DELISTED
Vincerx Pharma, Inc. Common Stock
VINC
– –
-37,062
Closed -$7.55M
CERE
124
DELISTED
Cerevel Therapeutics Holdings, Inc. Common Stock
CERE
– –
-666,666
Closed -$21.6M
ISEE
125
DELISTED
IVERIC bio, Inc. Common Stock
ISEE
– –
-6,722,624
Closed -$112M
2 3 4
5
6

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MF
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RTW Investments's Q1 2022 Portfolio in Review

As of Q1 2022, RTW Investments held 126 positions worth $4.83B, down 29% from $6.85B the previous quarter. Its ten largest holdings account for 39% of the portfolio.

RTW Investments withdrew a net $868M in Q1 2022, closing 20 positions and reducing 30 holdings. Its most notable exit was State Street SPDR S&P 500 ETF Trust, an estimated $423M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 99% of assets, up from 93% a quarter earlier, followed by Financials.

Against the trend, RTW Investments opened a new position in CinCor Pharma, Inc. Common Stock worth $24.4M.

  • RTW Investments's largest Q1 2022 buy was CinCor Pharma, Inc. Common Stock: 1,389,705 shares worth $24.4M.
  • RTW Investments added most to Protagonist Therapeutics in Q1 2022, an estimated $61.8M increase.
  • RTW Investments's biggest Q1 2022 reduction was Apellis Pharmaceuticals, cutting an estimated $85.6M.
  • RTW Investments fully exited State Street SPDR S&P 500 ETF Trust in Q1 2022, selling an estimated $423M.
  • RTW Investments's ten largest holdings make up 39% of its $4.83B portfolio in Q1 2022.
  • RTW Investments opened 2 new positions and closed 20 in Q1 2022.
  • RTW Investments's portfolio value fell 29% quarter-over-quarter to $4.83B.

Based on RTW Investments's 13F filing for Q1 2022, filed 16 May 2022.