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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+4.01%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$6.54B
AUM Growth
-$74.4M
Cap. Flow
+$91.3M
Cap. Flow %
1.4%
Top 10 Hldgs %
52.67%
Holding
82
New
10
Increased
18
Reduced
7
Closed
14

Top Buys

Rank Stock Value
1
ISRG icon
Intuitive Surgical
ISRG
+$112M
2
BBNX
Beta Bionics
BBNX
+$61.5M
3
VRNA
Verona Pharma
VRNA
+$61.5M
4
QURE icon
uniQure
QURE
+$47.1M
5
GEHC icon
GE HealthCare
GEHC
+$44.7M

Top Sells

Rank Stock Value
1
BRKR icon
Bruker
BRKR
+$145M
2
AXSM icon
Axsome Therapeutics
AXSM
+$129M
3
DYN icon
Dyne Therapeutics
DYN
+$50.5M
4
ETNB
89bio
ETNB
+$48.2M
5
ALKS icon
Alkermes
ALKS
+$22M

Sector Composition

Rank Sector Weight
1 Healthcare 99.88%
2 Financials 0.12%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
MDGL icon
1
Madrigal Pharmaceuticals
MDGL
$12.8B
$660M 10.1%
1,993,687
– –
ARGX icon
2
argenx
ARGX
$56.3B
$399M 6.1%
673,497
– –
PTCT icon
3
PTC Therapeutics
PTCT
$6.31B
$381M 5.83%
7,483,127
+90,000
+1% +$4.49M
NTRA icon
4
Natera
NTRA
$37.1B
$367M 5.61%
2,593,546
+223
+0% +$35.8K
AXSM icon
5
Axsome Therapeutics
AXSM
$12.3B
$341M 5.21%
2,922,729
-1,128,636
-28% -$129M
AKRO
6
DELISTED
Akero Therapeutics
AKRO
$300M 4.59%
7,419,340
+559,517
+8% +$23.7M
PTGX icon
7
Protagonist Therapeutics
PTGX
$8.79B
$277M 4.23%
5,719,415
+220,870
+4% +$9.26M
RNAM
8
DELISTED
Avidity Biosciences
RNAM
$258M 3.95%
8,746,926
+814,056
+10% +$25.4M
PEN icon
9
Penumbra
PEN
$12.6B
$231M 3.53%
862,770
+320
+0% +$86.6K
INSM icon
10
Insmed
INSM
$23B
$230M 3.52%
3,014,558
– –
ALKS icon
11
Alkermes
ALKS
$8.77B
$227M 3.48%
6,884,698
-673,137
-9% -$22M
SYK icon
12
Stryker
SYK
$129B
$220M 3.36%
590,221
– –
VRNA
13
DELISTED
Verona Pharma
VRNA
$181M 2.77%
2,848,800
+1,027,781
+56% +$61.5M
MRUS
14
DELISTED
Merus
MRUS
$175M 2.68%
4,169,393
– –
TARS icon
15
Tarsus Pharmaceuticals
TARS
$2.64B
$170M 2.61%
3,316,032
+79,483
+2% +$3.93M
IMCR icon
16
Immunocore
IMCR
$1.74B
$144M 2.21%
4,869,798
– –
ACAD icon
17
Acadia Pharmaceuticals
ACAD
$4.39B
$142M 2.17%
8,540,117
-165,384
-2% -$3M
RCKT icon
18
Rocket Pharmaceuticals
RCKT
$359M
$118M 1.8%
17,687,772
– –
RDNT icon
19
RadNet
RDNT
$4.89B
$115M 1.76%
2,317,582
+339,000
+17% +$20.1M
MASI
20
DELISTED
Masimo
MASI
$114M 1.74%
683,294
– –
ZLAB icon
21
Zai Lab
ZLAB
$2.11B
$113M 1.73%
3,136,680
+627,561
+25% +$19.3M
CYTK icon
22
Cytokinetics
CYTK
$11.1B
$109M 1.67%
2,721,158
– –
ESTA icon
23
Establishment Labs
ESTA
$2.69B
$105M 1.61%
2,583,887
+14,200
+0.6% +$529K
APGE icon
24
Apogee Therapeutics
APGE
$10.2B
$101M 1.55%
2,712,097
– –
ISRG icon
25
Intuitive Surgical
ISRG
$128B
$100M 1.53%
+202,456
New +$112M
1
2 3 4

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OAM
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RTW Investments's Q1 2025 Portfolio in Review

As of Q1 2025, RTW Investments held 82 positions worth $6.54B, down 1.1% from $6.61B the previous quarter. Its ten largest holdings account for 53% of the portfolio.

RTW Investments's Q1 2025 filing shows 10 new, 18 increased, 7 reduced and 14 closed positions. Its largest new stake was Intuitive Surgical: 202,456 shares worth $100M. The largest sale was Bruker, an estimated $145M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, down from 100% a quarter earlier, followed by Financials.

  • RTW Investments's largest Q1 2025 buy was Intuitive Surgical: 202,456 shares worth $100M.
  • RTW Investments added most to Verona Pharma in Q1 2025, an estimated $61.5M increase.
  • RTW Investments's biggest Q1 2025 reduction was Axsome Therapeutics, cutting an estimated $129M.
  • RTW Investments fully exited Bruker in Q1 2025, selling an estimated $145M.
  • RTW Investments's ten largest holdings make up 53% of its $6.54B portfolio in Q1 2025.
  • RTW Investments opened 10 new positions and closed 14 in Q1 2025.
  • RTW Investments's portfolio value fell 1.1% quarter-over-quarter to $6.54B.

Based on RTW Investments's 13F filing for Q1 2025, filed 15 May 2025.