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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+5.22%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$6.61B
AUM Growth
-$298M
Cap. Flow
-$123M
Cap. Flow %
-1.86%
Top 10 Hldgs %
48.57%
Holding
77
New
9
Increased
21
Reduced
16
Closed
5

Top Buys

Rank Stock Value
1
GMED icon
Globus Medical
GMED
+$76.7M
2
SYK icon
Stryker
SYK
+$71.6M
3
ZLAB icon
Zai Lab
ZLAB
+$69.6M
4
VRNA
Verona Pharma
VRNA
+$68.4M
5
XNCR icon
Xencor
XNCR
+$42M

Top Sells

Rank Stock Value
1
GERN icon
Geron
GERN
+$200M
2
MASI
Masimo
MASI
+$123M
3
ACAD icon
Acadia Pharmaceuticals
ACAD
+$80.7M
4
BRKR icon
Bruker
BRKR
+$59.1M
5
GKOS icon
Glaukos
GKOS
+$50.3M

Sector Composition

Rank Sector Weight
1 Healthcare 99.89%
2 Financials 0.11%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
MDGL icon
1
Madrigal Pharmaceuticals
MDGL
$12.4B
$615M 9.3%
1,993,687
– –
ARGX icon
2
argenx
ARGX
$52.9B
$414M 6.26%
673,497
+19,067
+3% +$11.2M
NTRA icon
3
Natera
NTRA
$37.6B
$411M 6.21%
2,593,323
– –
AXSM icon
4
Axsome Therapeutics
AXSM
$11.4B
$343M 5.18%
4,051,365
-138,192
-3% -$12.7M
PTCT icon
5
PTC Therapeutics
PTCT
$6.47B
$334M 5.05%
7,393,127
– –
RNAM
6
DELISTED
Avidity Biosciences
RNAM
$231M 3.49%
7,932,870
-200,000
-2% -$8.36M
RCKT icon
7
Rocket Pharmaceuticals
RCKT
$375M
$222M 3.36%
17,687,772
– –
ALKS icon
8
Alkermes
ALKS
$8.62B
$217M 3.29%
7,557,835
+903,802
+14% +$26M
SYK icon
9
Stryker
SYK
$122B
$213M 3.21%
590,221
+193,300
+49% +$71.6M
PTGX icon
10
Protagonist Therapeutics
PTGX
$8.64B
$212M 3.21%
5,498,545
+72,433
+1% +$3.16M
INSM icon
11
Insmed
INSM
$23.2B
$208M 3.15%
3,014,558
-257,450
-8% -$18.5M
PEN icon
12
Penumbra
PEN
$12.5B
$205M 3.1%
862,450
+66,700
+8% +$15.2M
AKRO
13
DELISTED
Akero Therapeutics
AKRO
$191M 2.89%
6,859,823
+940,388
+16% +$28.5M
TARS icon
14
Tarsus Pharmaceuticals
TARS
$2.45B
$179M 2.71%
3,236,549
-175,937
-5% -$7.99M
MRUS
15
DELISTED
Merus
MRUS
$175M 2.65%
4,169,393
– –
ACAD icon
16
Acadia Pharmaceuticals
ACAD
$4.3B
$160M 2.42%
8,705,501
-5,002,005
-36% -$80.7M
BRKR icon
17
Bruker
BRKR
$8.55B
$145M 2.2%
2,481,119
-1,000,000
-29% -$59.1M
IMCR icon
18
Immunocore
IMCR
$1.73B
$144M 2.17%
4,869,798
– –
RDNT icon
19
RadNet
RDNT
$4.77B
$138M 2.09%
1,978,582
+169,978
+9% +$12.5M
CYTK icon
20
Cytokinetics
CYTK
$10.7B
$128M 1.94%
2,721,158
– –
DYN icon
21
Dyne Therapeutics
DYN
$3.88B
$123M 1.86%
5,218,641
-1,600,000
-23% -$47.3M
APGE icon
22
Apogee Therapeutics
APGE
$10.1B
$123M 1.86%
2,712,097
+1
+0% +$51
ESTA icon
23
Establishment Labs
ESTA
$2.75B
$118M 1.79%
2,569,687
-76,016
-3% -$3.31M
MASI
24
DELISTED
Masimo
MASI
$113M 1.71%
683,294
-779,106
-53% -$123M
VRNA
25
DELISTED
Verona Pharma
VRNA
$84.6M 1.28%
+1,821,019
New +$68.4M
1
2 3 4

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MG
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LWCFA
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RTW Investments's Q4 2024 Portfolio in Review

As of Q4 2024, RTW Investments held 77 positions worth $6.61B, down 4.3% from $6.91B the previous quarter. Its ten largest holdings account for 49% of the portfolio.

RTW Investments's Q4 2024 filing shows 9 new, 21 increased, 16 reduced and 5 closed positions. Its largest new stake was Globus Medical: 972,000 shares worth $80.4M. The largest sale was Geron, an estimated $200M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, down from 100% a quarter earlier, followed by Financials.

  • RTW Investments's largest Q4 2024 buy was Globus Medical: 972,000 shares worth $80.4M.
  • RTW Investments added most to Stryker in Q4 2024, an estimated $71.6M increase.
  • RTW Investments's biggest Q4 2024 reduction was Masimo, cutting an estimated $123M.
  • RTW Investments fully exited Geron in Q4 2024, selling an estimated $200M.
  • RTW Investments's ten largest holdings make up 49% of its $6.61B portfolio in Q4 2024.
  • RTW Investments opened 9 new positions and closed 5 in Q4 2024.
  • RTW Investments's portfolio value fell 4.3% quarter-over-quarter to $6.61B.

Based on RTW Investments's 13F filing for Q4 2024, filed 14 Feb 2025.