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RTW Investments Portfolio holdings

AUM $11.7B
1-Year Est. Return 174.13%
This Fund
S&P 500
This Quarter Est. Return
+2.62%
1 Year Est. Return
+174.13%
3 Year Est. Return
+466.81%
5 Year Est. Return
+622.69%
10 Year Est. Return
+19,772.83%
AUM
$6.41B
AUM Growth
+$445M
Cap. Flow
+$949M
Cap. Flow %
14.82%
Top 10 Hldgs %
42.9%
Holding
120
New
18
Increased
32
Reduced
16
Closed
9

Top Buys

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$365M
2
QDEL icon
QuidelOrtho
QDEL
+$162M
3
RXDX
Prometheus Biosciences, Inc. Common Stock
RXDX
+$67.4M
4
PTCT icon
PTC Therapeutics
PTCT
+$63.7M
5
ITOS
iTeos Therapeutics
ITOS
+$61M

Top Sells

Rank Stock Value
1
KRRO icon
Korro Bio
KRRO
+$86.8M
2
RCKT icon
Rocket Pharmaceuticals
RCKT
+$73.8M
3
FPRX
Five Prime Therapeutics, Inc.
FPRX
+$42.8M
4
IMVT icon
Immunovant
IMVT
+$32.6M
5
PEN icon
Penumbra
PEN
+$20.7M

Sector Composition

Rank Sector Weight
1 Healthcare 93.65%
2 Miscellaneous 6.01%
3 Financials 0.35%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
RCKT icon
1
Rocket Pharmaceuticals
RCKT
$374M
$697M 10.89%
15,715,286
-1,344,925
-8% -$73.8M
SPY icon
2
State Street SPDR S&P 500 ETF Trust
SPY
$799B
$375M 5.85%
+946,255
New +$365M
VCEL icon
3
Vericel Corp
VCEL
$2.03B
$251M 3.92%
4,517,570
– –
PTCT icon
4
PTC Therapeutics
PTCT
$5.48B
$251M 3.91%
5,293,966
+1,072,130
+25% +$63.7M
ALNY icon
5
Alnylam Pharmaceuticals
ALNY
$31.9B
$238M 3.71%
1,683,362
+1,717
+0.1% +$258K
MRTX
6
DELISTED
Mirati Therapeutics, Inc. Common Stock
MRTX
$228M 3.57%
1,333,232
+278,868
+26% +$55.2M
DRNA
7
DELISTED
Dicerna Pharmaceuticals, Inc.
DRNA
$191M 2.98%
7,463,291
+209,434
+3% +$5.35M
ILMN icon
8
Illumina
ILMN
$33.6B
$185M 2.89%
495,451
+123,543
+33% +$50.4M
NTRA icon
9
Natera
NTRA
$50.6B
$174M 2.71%
1,712,234
– –
DMTK
10
DELISTED
DermTech, Inc. Common Stock
DMTK
$158M 2.47%
3,118,665
+231,450
+8% +$12.1M
ESTA icon
11
Establishment Labs
ESTA
$2.13B
$145M 2.26%
2,319,138
– –
STOK icon
12
Stoke Therapeutics
STOK
$1.82B
$142M 2.21%
3,644,248
+100,000
+3% +$5.69M
MASI
13
DELISTED
Masimo
MASI
$137M 2.13%
594,956
+125,540
+27% +$31.5M
TXG icon
14
10x Genomics
TXG
$9.69B
$129M 2.01%
711,515
+50,582
+8% +$8.73M
CERN
15
DELISTED
Cerner Corp
CERN
$128M 1.99%
1,774,485
+72,805
+4% +$5.47M
AXNX
16
DELISTED
Axonics, Inc. Common Stock
AXNX
$113M 1.76%
1,883,864
– –
QDEL icon
17
QuidelOrtho
QDEL
$729M
$112M 1.75%
+878,533
New +$162M
ARVN icon
18
Arvinas
ARVN
$540M
$107M 1.67%
1,622,799
-168,197
-9% -$12.9M
GMED icon
19
Globus Medical
GMED
$10B
$103M 1.61%
1,670,811
+29,952
+2% +$1.9M
IMVT icon
20
Immunovant
IMVT
$7.57B
$102M 1.59%
6,356,743
-1,235,510
-16% -$32.6M
TNDM icon
21
Tandem Diabetes Care
TNDM
$1.13B
$101M 1.57%
1,139,230
+478,248
+72% +$44.4M
ITOS
22
DELISTED
iTeos Therapeutics
ITOS
$94.4M 1.47%
2,762,791
+1,688,625
+157% +$61M
GH icon
23
Guardant Health
GH
$23.6B
$93.1M 1.45%
609,774
+27,804
+5% +$4.2M
AXSM icon
24
Axsome Therapeutics
AXSM
$10.7B
$91.5M 1.43%
1,616,497
-55,919
-3% -$3.93M
PTGX icon
25
Protagonist Therapeutics
PTGX
$9.28B
$90.8M 1.42%
3,507,390
-142,679
-4% -$3.61M
1
2 3 4 5

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CIM
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MIF
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QC
Quadrature Capital London, United Kingdom $11.7B AUM 87.29% 1-Year Est. Return
UE
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CIA
Concurrent Investment Advisors Tampa, Florida $11.8B AUM 31.86% 1-Year Est. Return
FPAS
Focus Partners Advisor Solutions Saint Louis, Missouri $11.8B AUM 25.68% 1-Year Est. Return
CCMT
CMT Capital Markets Trading Frankfurt, Germany $11.8B AUM 39.43% 1-Year Est. Return
Polen Capital Management
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RTW Investments's Q1 2021 Portfolio in Review

As of Q1 2021, RTW Investments held 120 positions worth $6.41B, up 7.5% from $5.96B the previous quarter. Its ten largest holdings account for 43% of the portfolio.

RTW Investments deployed $949M of net new capital in Q1 2021, opening 18 new positions and adding to 32 existing holdings. Its largest new stake was State Street SPDR S&P 500 ETF Trust: 946,255 shares worth $375M.

By sector, the portfolio is most concentrated in Healthcare at 94% of assets, down from 100% a quarter earlier, followed by Miscellaneous and Financials.

On the sell side, the largest reduction was Rocket Pharmaceuticals, an estimated $73.8M trimmed.

  • RTW Investments's largest Q1 2021 buy was State Street SPDR S&P 500 ETF Trust: 946,255 shares worth $375M.
  • RTW Investments added most to PTC Therapeutics in Q1 2021, an estimated $63.7M increase.
  • RTW Investments's biggest Q1 2021 reduction was Rocket Pharmaceuticals, cutting an estimated $73.8M.
  • RTW Investments fully exited Korro Bio in Q1 2021, selling an estimated $86.8M.
  • RTW Investments's ten largest holdings make up 43% of its $6.41B portfolio in Q1 2021.
  • RTW Investments opened 18 new positions and closed 9 in Q1 2021.
  • RTW Investments's portfolio value rose 7.5% quarter-over-quarter to $6.41B.

Based on RTW Investments's 13F filing for Q1 2021, filed 14 May 2021.