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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+7.37%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$6.91B
AUM Growth
+$452M
Cap. Flow
+$173M
Cap. Flow %
2.51%
Top 10 Hldgs %
46.12%
Holding
78
New
10
Increased
15
Reduced
10
Closed
10

Top Buys

Rank Stock Value
1
GERN icon
Geron
GERN
+$201M
2
SYK icon
Stryker
SYK
+$137M
3
ORKA
Oruka Therapeutics
ORKA
+$60.3M
4
MDGL icon
Madrigal Pharmaceuticals
MDGL
+$19.9M
5
DYN icon
Dyne Therapeutics
DYN
+$17.2M

Top Sells

Rank Stock Value
1
ISRG icon
Intuitive Surgical
ISRG
+$90.1M
2
RARE icon
Ultragenyx Pharmaceutical
RARE
+$65.8M
3
AXSM icon
Axsome Therapeutics
AXSM
+$38.8M
4
VCEL icon
Vericel Corp
VCEL
+$36.8M
5
FULC icon
Fulcrum Therapeutics
FULC
+$36.2M

Sector Composition

Rank Sector Weight
1 Healthcare 99.89%
2 Financials 0.11%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
MDGL icon
1
Madrigal Pharmaceuticals
MDGL
$12.4B
$423M 6.12%
1,993,687
+77,825
+4% +$19.9M
AXSM icon
2
Axsome Therapeutics
AXSM
$11.5B
$377M 5.45%
4,189,557
-444,774
-10% -$38.8M
RNAM
3
DELISTED
Avidity Biosciences
RNAM
$374M 5.4%
8,132,870
-673,968
-8% -$29.2M
ARGX icon
4
argenx
ARGX
$53.4B
$355M 5.13%
654,430
– –
NTRA icon
5
Natera
NTRA
$37.9B
$329M 4.76%
2,593,323
– –
RCKT icon
6
Rocket Pharmaceuticals
RCKT
$376M
$327M 4.73%
17,687,772
– –
PTCT icon
7
PTC Therapeutics
PTCT
$6.47B
$274M 3.97%
7,393,127
– –
DYN icon
8
Dyne Therapeutics
DYN
$3.88B
$245M 3.54%
6,818,641
+431,503
+7% +$17.2M
PTGX icon
9
Protagonist Therapeutics
PTGX
$8.73B
$244M 3.53%
5,426,112
+139,708
+3% +$5.64M
BRKR icon
10
Bruker
BRKR
$8.6B
$240M 3.48%
3,481,119
+37,024
+1% +$2.39M
INSM icon
11
Insmed
INSM
$23.3B
$239M 3.46%
3,272,008
-368,100
-10% -$27.2M
ACAD icon
12
Acadia Pharmaceuticals
ACAD
$4.33B
$211M 3.05%
13,707,506
– –
MRUS
13
DELISTED
Merus
MRUS
$208M 3.01%
4,169,393
– –
GERN icon
14
Geron
GERN
$930M
$200M 2.9%
+44,111,916
New +$201M
MASI
15
DELISTED
Masimo
MASI
$195M 2.82%
1,462,400
– –
ALKS icon
16
Alkermes
ALKS
$8.67B
$186M 2.69%
6,654,033
-402,955
-6% -$10.7M
AKRO
17
DELISTED
Akero Therapeutics
AKRO
$170M 2.46%
5,919,435
+487,450
+9% +$12.7M
APGE icon
18
Apogee Therapeutics
APGE
$10.1B
$159M 2.31%
2,712,096
– –
PEN icon
19
Penumbra
PEN
$12.5B
$155M 2.24%
795,750
+53,645
+7% +$10.1M
IMCR icon
20
Immunocore
IMCR
$1.74B
$152M 2.19%
4,869,798
– –
CYTK icon
21
Cytokinetics
CYTK
$10.8B
$144M 2.08%
2,721,158
– –
SYK icon
22
Stryker
SYK
$122B
$143M 2.07%
+396,921
New +$137M
RDNT icon
23
RadNet
RDNT
$4.75B
$125M 1.82%
1,808,604
-47,406
-3% -$2.99M
ESTA icon
24
Establishment Labs
ESTA
$2.77B
$114M 1.66%
2,645,703
-30,000
-1% -$1.3M
IMTX icon
25
Immatics
IMTX
$1.26B
$114M 1.65%
10,000,000
– –
1
2 3 4

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LWCFA
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RTW Investments's Q3 2024 Portfolio in Review

As of Q3 2024, RTW Investments held 78 positions worth $6.91B, up 7% from $6.46B the previous quarter. Its ten largest holdings account for 46% of the portfolio.

RTW Investments's Q3 2024 filing shows 10 new, 15 increased, 10 reduced and 10 closed positions. Its largest new stake was Geron: 44,111,916 shares worth $200M. The largest sale was Intuitive Surgical, an estimated $90.1M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, up from 100% a quarter earlier, followed by Financials.

  • RTW Investments's largest Q3 2024 buy was Geron: 44,111,916 shares worth $200M.
  • RTW Investments added most to Oruka Therapeutics in Q3 2024, an estimated $60.3M increase.
  • RTW Investments's biggest Q3 2024 reduction was Ultragenyx Pharmaceutical, cutting an estimated $65.8M.
  • RTW Investments fully exited Intuitive Surgical in Q3 2024, selling an estimated $90.1M.
  • RTW Investments's ten largest holdings make up 46% of its $6.91B portfolio in Q3 2024.
  • RTW Investments opened 10 new positions and closed 10 in Q3 2024.
  • RTW Investments's portfolio value rose 7% quarter-over-quarter to $6.91B.

Based on RTW Investments's 13F filing for Q3 2024, filed 14 Nov 2024.