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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+9.72%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$6.63B
AUM Growth
+$221M
Cap. Flow
-$85.5M
Cap. Flow %
-1.29%
Top 10 Hldgs %
45.03%
Holding
125
New
14
Increased
22
Reduced
8
Closed
12

Top Buys

1
EPIX
ESSA Pharma
EPIX
+$80.5M
2
MASI
Masimo
MASI
+$52.8M
3
RGNX icon
Regenxbio
RGNX
+$48M
4
GHRS icon
GH Research
GHRS
+$44.3M
5
GH icon
Guardant Health
GH
+$41.5M

Top Sells

1
CERN
Cerner Corp
CERN
+$128M
2
ARVN icon
Arvinas
ARVN
+$107M
3
IMVT icon
Immunovant
IMVT
+$102M
4
TBIO
Translate Bio, Inc. Common Stock
TBIO
+$72.3M
5
CRIS icon
Curis
CRIS
+$41M

Sector Composition

1 Healthcare 88.48%
2 Financials 0.38%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
RCKT icon
1
Rocket Pharmaceuticals
RCKT
$376M
$664M 10.02%
14,990,286
-725,000
-5% -$31.5M
SPY icon
2
State Street SPDR S&P 500 ETF Trust
SPY
$774B
$426M 6.44%
996,255
+50,000
+5% +$20.9M
ALNY icon
3
Alnylam Pharmaceuticals
ALNY
$35.7B
$285M 4.31%
1,683,362
– –
DRNA
4
DELISTED
Dicerna Pharmaceuticals, Inc.
DRNA
$281M 4.24%
7,521,859
+58,568
+0.8% +$1.8M
VCEL icon
5
Vericel Corp
VCEL
$2.38B
$237M 3.58%
4,517,570
– –
MRTX
6
DELISTED
Mirati Therapeutics, Inc. Common Stock
MRTX
$235M 3.55%
1,457,532
+124,300
+9% +$20M
ILMN icon
7
Illumina
ILMN
$28.2B
$228M 3.45%
496,309
+858
+0.2% +$346K
PTCT icon
8
PTC Therapeutics
PTCT
$6.52B
$224M 3.38%
5,293,966
– –
ESTA icon
9
Establishment Labs
ESTA
$2.72B
$203M 3.06%
2,319,138
– –
MASI
10
DELISTED
Masimo
MASI
$200M 3.02%
826,210
+231,254
+39% +$52.8M
NTRA icon
11
Natera
NTRA
$38.9B
$194M 2.93%
1,712,234
– –
PTGX icon
12
Protagonist Therapeutics
PTGX
$9.06B
$157M 2.38%
3,507,390
– –
TXG icon
13
10x Genomics
TXG
$5.55B
$144M 2.17%
734,481
+22,966
+3% +$4.16M
CLDX icon
14
Celldex Therapeutics
CLDX
$2.77B
$131M 1.97%
3,908,947
– –
DMTK
15
DELISTED
DermTech, Inc. Common Stock
DMTK
$130M 1.96%
3,118,665
– –
GMED icon
16
Globus Medical
GMED
$10.5B
$130M 1.95%
1,670,811
– –
AXNX
17
DELISTED
Axonics, Inc. Common Stock
AXNX
$123M 1.86%
1,943,864
+60,000
+3% +$3.54M
STOK icon
18
Stoke Therapeutics
STOK
$1.81B
$123M 1.85%
3,644,248
– –
GH icon
19
Guardant Health
GH
$20.7B
$114M 1.72%
918,253
+308,479
+51% +$41.5M
QDEL icon
20
QuidelOrtho
QDEL
$1.19B
$113M 1.7%
878,533
– –
TNDM icon
21
Tandem Diabetes Care
TNDM
$1.17B
$112M 1.69%
1,147,408
+8,178
+0.7% +$729K
AXSM icon
22
Axsome Therapeutics
AXSM
$11.8B
$109M 1.65%
1,616,497
– –
RNAM
23
DELISTED
Avidity Biosciences
RNAM
$98.7M 1.49%
3,995,000
– –
EPIX
24
DELISTED
ESSA Pharma
EPIX
$87.3M 1.32%
3,053,919
+2,770,227
+976% +$80.5M
CCCC icon
25
C4 Therapeutics
CCCC
$408M
$81.3M 1.23%
2,149,228
– –
1
2 3 4 5

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RTW Investments's Q2 2021 Portfolio in Review

As of Q2 2021, RTW Investments held 125 positions worth $6.63B, up 3.5% from $6.41B the previous quarter. Its ten largest holdings account for 45% of the portfolio.

RTW Investments's Q2 2021 filing shows 14 new, 22 increased, 8 reduced and 12 closed positions. Its largest new stake was GH Research: 2,168,957 shares worth $42.7M. The largest sale was Cerner Corp, an estimated $128M.

By sector, the portfolio is most concentrated in Healthcare at 88% of assets, up from 88% a quarter earlier, followed by Financials.

  • RTW Investments's largest Q2 2021 buy was GH Research: 2,168,957 shares worth $42.7M.
  • RTW Investments added most to ESSA Pharma in Q2 2021, an estimated $80.5M increase.
  • RTW Investments's biggest Q2 2021 reduction was Rocket Pharmaceuticals, cutting an estimated $31.5M.
  • RTW Investments fully exited Cerner Corp in Q2 2021, selling an estimated $128M.
  • RTW Investments's ten largest holdings make up 45% of its $6.63B portfolio in Q2 2021.
  • RTW Investments opened 14 new positions and closed 12 in Q2 2021.
  • RTW Investments's portfolio value rose 3.5% quarter-over-quarter to $6.63B.

Based on RTW Investments's 13F filing for Q2 2021, filed 13 Aug 2021.