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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+31.09%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$9.98B
AUM Growth
+$1.87B
Cap. Flow
+$293M
Cap. Flow %
2.94%
Top 10 Hldgs %
50.46%
Holding
103
New
29
Increased
20
Reduced
12
Closed
12

Top Buys

Rank Stock Value
1
INSM icon
Insmed
INSM
+$321M
2
IRTC icon
iRhythm Holdings
IRTC
+$209M
3
APLS
Apellis Pharmaceuticals
APLS
+$180M
4
RGEN icon
Repligen
RGEN
+$167M
5
COGT icon
Cogent Biosciences
COGT
+$116M

Top Sells

Rank Stock Value
1
RNAM
Avidity Biosciences
RNAM
+$496M
2
AKRO
Akero Therapeutics
AKRO
+$260M
3
MRUS
Merus
MRUS
+$191M
4
NTRA icon
Natera
NTRA
+$104M
5
SYK icon
Stryker
SYK
+$89.3M

Sector Composition

Rank Sector Weight
1 Healthcare 99.9%
2 Financials 0.1%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
KOD icon
51
Kodiak Sciences
KOD
$2.84B
$41.6M 0.42%
+1,487,933
New +$30.5M
AQST icon
52
Aquestive Therapeutics
AQST
$494M
$40.4M 0.4%
6,250,000
– –
ARWR icon
53
Arrowhead Research
ARWR
$12.4B
$38.8M 0.39%
+584,716
New +$28.7M
SVRA icon
54
Savara
SVRA
$1.19B
$35.9M 0.36%
+5,952,380
New +$29.2M
OBIO icon
55
Orchestra BioMed
OBIO
$254M
$34.5M 0.35%
8,306,063
– –
NGNE icon
56
Neurogene
NGNE
$712M
$28.1M 0.28%
1,362,456
– –
WVE icon
57
Wave Life Sciences
WVE
$1.2B
$22.9M 0.23%
1,350,000
+450,000
+50% +$4.57M
JBIO
58
Jade Biosciences
JBIO
$1.34B
$22.4M 0.22%
1,449,273
– –
EVMN
59
Evommune Inc
EVMN
$511M
$22M 0.22%
+1,283,671
New +$24.1M
KYMR icon
60
Kymera Therapeutics
KYMR
$8.94B
$18.7M 0.19%
+240,000
New +$16.2M
FLGT icon
61
Fulgent Genetics
FLGT
$527M
$18.5M 0.19%
+705,027
New +$18.3M
CGEM icon
62
Cullinan Oncology
CGEM
$1.14B
$17.7M 0.18%
1,705,960
– –
HNGE
63
Hinge Health
HNGE
$7.21B
$16.4M 0.16%
+353,500
New +$17M
BEAM icon
64
Beam Therapeutics
BEAM
$2.84B
$15.8M 0.16%
+570,394
New +$14.6M
HTFL
65
Heartflow Inc
HTFL
$2.49B
$14.4M 0.14%
495,000
– –
CMPX icon
66
Compass Therapeutics
CMPX
$387M
$13.4M 0.13%
2,500,000
– –
TNGX icon
67
Tango Therapeutics
TNGX
$4.41B
$13.2M 0.13%
+1,491,228
New +$12.8M
LMRI
68
Lumexa Imaging Holdings
LMRI
$1.11B
$12M 0.12%
+650,000
New +$11.7M
LRMR icon
69
Larimar Therapeutics
LRMR
$432M
$11.9M 0.12%
3,125,000
– –
TEM
70
Tempus AI
TEM
$9.39B
$11.8M 0.12%
200,000
– –
KLRS
71
Kalaris Therapeutics
KLRS
$96.8M
$11M 0.11%
+1,300,000
New +$8.31M
IQV icon
72
IQVIA
IQV
$39.3B
$10.4M 0.1%
+46,000
New +$10M
PCSC
73
DELISTED
Perceptive Capital Solutions
PCSC
$9.67M 0.1%
742,500
– –
ATAI icon
74
AtaiBeckley Inc
ATAI
$2.68B
$8.18M 0.08%
+2,000,000
New +$9.44M
ALUR
75
DELISTED
Allurion Technologies
ALUR
$7.25M 0.07%
5,891,430
+3,348,827
+132% +$5.62M
1 2
3
4 5

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RTW Investments's Q4 2025 Portfolio in Review

As of Q4 2025, RTW Investments held 103 positions worth $9.98B, up 23% from $8.12B the previous quarter. Its ten largest holdings account for 50% of the portfolio.

RTW Investments's Q4 2025 filing shows 29 new, 20 increased, 12 reduced and 12 closed positions. Its largest new stake was iRhythm Holdings: 1,181,990 shares worth $210M. The largest sale was Avidity Biosciences, an estimated $496M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, down from 100% a quarter earlier, followed by Financials.

  • RTW Investments's largest Q4 2025 buy was iRhythm Holdings: 1,181,990 shares worth $210M.
  • RTW Investments added most to Insmed in Q4 2025, an estimated $321M increase.
  • RTW Investments's biggest Q4 2025 reduction was Natera, cutting an estimated $104M.
  • RTW Investments fully exited Avidity Biosciences in Q4 2025, selling an estimated $496M.
  • RTW Investments's ten largest holdings make up 50% of its $9.98B portfolio in Q4 2025.
  • RTW Investments opened 29 new positions and closed 12 in Q4 2025.
  • RTW Investments's portfolio value rose 23% quarter-over-quarter to $9.98B.

Based on RTW Investments's 13F filing for Q4 2025, filed 17 Feb 2026.