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SPDR S&P Biotech ETF
XBI

Overview Fund Activity

613 hedge funds and large institutions have $9.73B invested in SPDR S&P Biotech ETF in 2025 Q2 according to their latest regulatory filings, with 54 funds opening new positions, 159 increasing their positions, 270 reducing their positions, and 101 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
613
Holders Change
-58
Holders Change %
-8.64%
% of All Funds
8.22%
Holding in Top 10
15
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.2%
New
54
Increased
159
Reduced
270
Closed
101
Calls
$1.47B
Puts
$2.24B
Net Calls
-$777M
Net Calls Change
+$309M

Top Buyers

1
Goldman Sachs
Goldman Sachs
New York
+$414M
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
+$303M
3
Citigroup
Citigroup
New York
+$189M
4
Wells Fargo
Wells Fargo
California
+$61.8M
5
JFG
Jefferies Financial Group
New York
+$52.8M

Top Sellers

1
DFG
Demars Financial Group
Washington
-$258M
2
UBS Group
UBS Group
Switzerland
-$256M
3
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
-$207M
4
HIIFS
Harel Insurance Investments & Financial Services
Israel
-$48.7M
5
Squarepoint
Squarepoint
New York
-$40.1M
Name Holding Trade Value Shares
Change 		Shares
Change %
Squarepoint
26
Squarepoint
New York
$39.2M -$40.1M -483,482 -51%
Royal Bank of Canada
27
Royal Bank of Canada
Ontario, Canada
$37.6M +$5.14M +61,986 +16%
CI
28
Clal Insurance
Israel
$35.5M +$14.4M +174,000 +69%
DCM
29
DAFNA Capital Management
California
$34.5M +$912K +11,000 +3%
MIH
30
Meitav Investment House
Israel
$33.2M +$31.8M +383,040 +2,200%
SO
31
STRS Ohio
Ohio
$31.5M +$3.08M +37,100 +11%
Twin Tree Management
32
Twin Tree Management
Texas
$30.5M +$3.48M +41,909 +13%
Millennium Management
33
Millennium Management
New York
$26.5M +$10.6M +127,235 +66%
SFS
34
Strategic Financial Services
New York
$23.3M +$1.56M +18,778 +7%
Neuberger Berman Group
35
Neuberger Berman Group
New York
$20.9M -$324K -3,903 -2%
SGH
36
Sivik Global Healthcare
Connecticut
$20.7M – – –
WT
37
Whittier Trust
California
$19.1M -$7.99M -96,332 -29%
BlackRock
38
BlackRock
New York
$19.1M +$1.16M +13,974 +6%
Balyasny Asset Management
39
Balyasny Asset Management
Illinois
$18M -$5.03M -60,598 -22%
OAM
40
Oxford Asset Management
United Kingdom
$17.8M +$11.1M +134,151 +167%
Stifel Financial
41
Stifel Financial
Missouri
$16.8M +$666K +8,025 +4%
G
42
GenTrust
Florida
$15.7M -$70.6K -851 -0.4%
OPCM
43
Osborne Partners Capital Management
California
$15.4M +$6.93M +83,572 +82%
UCMOK
44
United Capital Management of KS
Kansas
$15.3M +$424K +5,110 +3%
Susquehanna International Group
45
Susquehanna International Group
Pennsylvania
$15.1M -$23.2M -279,313 -61%
Rockefeller Capital Management
46
Rockefeller Capital Management
New York
$14.2M -$63.6K -767 -0.4%
VU
47
Vanderbilt University
Tennessee
$13.2M +$13.2M +158,746 New
Cetera Investment Advisers
48
Cetera Investment Advisers
Illinois
$13.1M +$281K +3,392 +2%
WAM
49
Weatherly Asset Management
California
$13M -$54K -651 -0.4%
RSCM
50
Rock Springs Capital Management
Maryland
$12.6M +$12.6M +151,750 New
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