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SPDR S&P Biotech ETF
XBI

Overview Fund Activity

671 hedge funds and large institutions have $9.23B invested in SPDR S&P Biotech ETF in 2025 Q1 according to their latest regulatory filings, with 72 funds opening new positions, 176 increasing their positions, 269 reducing their positions, and 120 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
671
Holders Change
-60
Holders Change %
-8.21%
% of All Funds
9.11%
Holding in Top 10
15
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-6.25%
% of All Funds
0.2%
New
72
Increased
176
Reduced
269
Closed
120
Calls
$1.08B
Puts
$2.17B
Net Calls
-$1.09B
Net Calls Change
+$169M

Top Buyers

1
UBS Group
UBS Group
Switzerland
+$294M
2
Goldman Sachs
Goldman Sachs
New York
+$287M
3
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
+$269M
4
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
+$191M
5
MIFH
Migdal Insurance & Financial Holdings
Israel
+$85.2M

Top Sellers

1
Bank of America
Bank of America
North Carolina
-$167M
2
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
-$145M
3
BCM
BlueCrest Capital Management
Jersey
-$138M
4
RCM
RA Capital Management
Massachusetts
-$111M
5
Citadel Advisors
Citadel Advisors
Florida
-$61M
Name Holding Trade Value Shares
Change 		Shares
Change %
CIA
301
Concurrent Investment Advisors
Florida
$690K +$430K +5,300 +165%
EWM
302
Evercore Wealth Management
New York
$689K – – –
SFS
303
Sowell Financial Services
Arkansas
$686K +$686K +8,463 New
SAM
304
Sherman Asset Management
California
$681K +$92.6K +1,142 +16%
WIA
305
World Investment Advisors
California
$670K -$15.7K -193 -2%
SFP
306
Shepherd Financial Partners
Massachusetts
$665K -$82K -1,011 -11%
TSW
307
Thompson Siegel & Walmsley
Virginia
$665K – – –
KIA
308
Knollwood Investment Advisory
Maryland
$663K – – –
CUAMC
309
China Universal Asset Management Company
China
$651K – – –
GPA
310
Guerra Pan Advisors
New Jersey
$629K – – –
BPAMU
311
BTG Pactual Asset Management US
New York
$618K -$152K -1,879 -20%
PFA
312
Petra Financial Advisors
Colorado
$598K -$94.3K -1,163 -14%
SFI
313
SPC Financial Inc
Maryland
$589K +$201K +2,479 +52%
TYCC
314
Texas Yale Capital Corp
Florida
$586K – – –
Comerica Bank
315
Comerica Bank
Texas
$586K -$220K -2,716 -27%
PCIA
316
Prime Capital Investment Advisors
Kansas
$585K +$129K +1,586 +28%
AAS
317
Avantax Advisory Services
Texas
$578K -$2.43K -30 -0.4%
CVM
318
Cheviot Value Management
California
$569K +$569K +6,885 New
VCM
319
Viewpoint Capital Management
Washington
$568K +$406K +5,000 +250%
BI
320
Bramshill Investments
Florida
$568K +$568K +7,000 New
EAM
321
Empirical Asset Management
Massachusetts
$556K -$199K -2,454 -26%
PGFC
322
Peapack-Gladstone Financial Corp
New Jersey
$556K -$30.4K -375 -5%
TFF
323
The Family Firm
Maryland
$551K – – –
Fidelity Investments
324
Fidelity Investments
Massachusetts
$550K +$8.03K +99 +1%
MCCA
325
Mill Creek Capital Advisors
Pennsylvania
$549K – – –
11 12
13
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