Comerica Bank’s State Street SPDR S&P Biotech ETF XBI Stock Holding History

Comerica Bank’s Portfolio XBI Stock Details XBI Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2025 Q4	$1.25M	Buy	10,270 +5,430	+112%	+$623K	0.01%	1389
2025 Q3	$485K	Sell	4,840 -2,139	-31%	-$193K	﹤0.01%	1904
2025 Q2	$579K	Sell	6,979 -244	-3%	-$19.5K	﹤0.01%	1803
2025 Q1	$586K	Sell	7,223 -2,716	-27%	-$243K	﹤0.01%	1770
2024 Q4	$895K	Sell	9,939 -344	-3%	-$33.3K	﹤0.01%	1613
2024 Q3	$1.02M	Sell	10,283 -2	-0%	-$197	﹤0.01%	1533
2024 Q2	$954K	Sell	10,285 -3,030	-23%	-$272K	﹤0.01%	1519
2024 Q1	$1.26M	Buy	13,315 +3,346	+34%	+$310K	0.01%	1417
2023 Q4	$890K	Buy	9,969 +2,802	+39%	+$208K	﹤0.01%	1585
2023 Q3	$523K	Buy	+7,167	New	+$572K	﹤0.01%	1771

Other funds holding XBI

Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return

BNP Paribas Financial Markets Paris, France $206B AUM 31.61% 1-Year Est. Return

Bank of America Charlotte, North Carolina $1.37T AUM 24.88% 1-Year Est. Return

Healthcare of Ontario Pension Plan (HOOPP) Trust Fund Toronto, Ontario, Canada $62.2B AUM 31.35% 1-Year Est. Return

Citigroup New York $303B AUM 53.02% 1-Year Est. Return

Morgan Stanley New York $1.66T AUM 25.57% 1-Year Est. Return

Wells Fargo San Francisco, California $530B AUM 22.01% 1-Year Est. Return

JP Morgan Chase New York $1.56T AUM 27.86% 1-Year Est. Return

UBS Group Zurich, Switzerland $666B AUM 30.12% 1-Year Est. Return

ACA

Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return

Comerica Bank's XBI Position: Q4 2025 in Review

Comerica Bank increased its State Street SPDR S&P Biotech ETF (XBI) stake by 112% in Q4 2025, buying an estimated $623K and bringing the position to 10,270 shares worth $1.25M. The position accounts for 0.01% of the portfolio, ranked #1389.

Comerica Bank first reported a position in XBI in Q3 2023 and has held it in 10 quarters since. The position peaked at $1.26M in Q1 2024. 813 funds tracked by Wall St. Rank hold XBI as of Q4 2025.

Comerica Bank held 10,270 shares of State Street SPDR S&P Biotech ETF worth $1.25M as of Q4 2025.
Comerica Bank bought 5,430 State Street SPDR S&P Biotech ETF shares in Q4 2025, an estimated $623K.
State Street SPDR S&P Biotech ETF made up 0.01% of Comerica Bank's portfolio in Q4 2025, its #1389 holding.
Comerica Bank first reported a position in State Street SPDR S&P Biotech ETF in Q3 2023 and has held it in 10 quarters since.
Comerica Bank's State Street SPDR S&P Biotech ETF position peaked at $1.26M in Q1 2024.
813 funds tracked by Wall St. Rank held State Street SPDR S&P Biotech ETF as of Q4 2025.

Based on Comerica Bank's 13F filing for Q4 2025, filed 29 Jan 2026.