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Tyra Biosciences
TYRA

164 hedge funds and large institutions have $2.52B invested in Tyra Biosciences in 2026 Q1 according to their latest regulatory filings, with 46 funds opening new positions, 59 increasing their positions, 35 reducing their positions, and 14 closing their positions.

New
Increased
Maintained
Reduced
Closed

229% more first-time investments, than exits

New positions opened: 46 | Existing positions closed: 14

69% more capital invested

Capital invested by funds: $1.49B → $2.52B (+$1.03B)

69% more repeat investments, than reductions

Existing positions increased: 59 | Existing positions reduced: 35

23% more funds holding

Funds holding: 133 → 164 (+31)

15.93% more ownership

Funds ownership: 106.47% → 122.41% (+16%)

0% more funds holding in top 10

Funds holding in top 10: 12 → 12 (0)

64% less call options, than puts

Call options by funds: $4.2M | Put options by funds: $11.6M

Holders
164
Holders Change
+31
Holders Change %
+23.31%
% of All Funds
2.02%
Holding in Top 10
12
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.15%
New
46
Increased
59
Reduced
35
Closed
14
Calls
$4.2M
Puts
$11.6M
Net Calls
-$7.43M
Net Calls Change
-$7.76M

Top Buyers

Rank Fund Capital Flow
1
Fidelity Investments
Fidelity Investments
Massachusetts
+$250M
2
PBA
Paradigm Biocapital Advisors
New York
+$66.5M
3
FCM
Farallon Capital Management
California
+$49M
4
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
+$31.5M
5
Janus Henderson Group
Janus Henderson Group
United Kingdom
+$30.9M

Top Sellers

Rank Fund Capital Flow
1
CPX
Canaan Partners XI
California
-$85M
2
VPC
Vestal Point Capital
New York
-$76.8M
3
KCM
Kynam Capital Management
New Jersey
-$41.1M
4
CC
Commodore Capital
New York
-$29.1M
5
Point72 Asset Management
Point72 Asset Management
Connecticut
-$27M
Name Holding Trade Value Shares
Change 		Change in
Stake
Dimensional Fund Advisors
51
Dimensional Fund Advisors
Texas
$3.52M -$123K -3,814 -4%
OC
52
Oppenheimer & Co
New York
$3.22M -$17.3K -534 -0.6%
XT
53
XTX Topco
Cayman Islands
$3.21M +$1.73M +53,482 +176%
SSA
54
Schonfeld Strategic Advisors
New York
$3.05M +$2.58M +79,592 New
CCM
55
Cinctive Capital Management
New York
$2.99M +$2.53M +78,018 New
Wellington Management Group
56
Wellington Management Group
Massachusetts
$2.96M -$878K -27,136 -26%
KCM
57
Kalehua Capital Management
Texas
$2.85M – – –
Ensign Peak Advisors
58
Ensign Peak Advisors
Utah
$2.84M +$2.4M +74,064 New
Bank of New York Mellon
59
Bank of New York Mellon
New York
$2.77M +$366K +11,312 +19%
Russell Investments Group
60
Russell Investments Group
United Kingdom
$2.7M +$1.86M +57,426 +442%
CCM
61
Catalio Capital Management
New York
$2.58M +$2.18M +67,285 New
UBS Group
62
UBS Group
Switzerland
$2.36M +$87.6K +2,705 +5%
JP Morgan Chase
63
JP Morgan Chase
New York
$2.31M -$142K -4,386 -6%
VPC
64
Vestal Point Capital
New York
$2.07M -$76.8M -2,371,000 -98%
N
65
Nuveen
North Carolina
$1.95M +$113K +3,491 +7%
TD Asset Management
66
TD Asset Management
Ontario, Canada
$1.92M +$1.62M +50,000 New
American Century Companies
67
American Century Companies
Missouri
$1.84M +$55.1K +1,702 +4%
AWA
68
Arkadios Wealth Advisors
Georgia
$1.82M +$1.54M +47,567 New
SPS
69
Susquehanna Portfolio Strategies
Pennsylvania
$1.8M -$52.4K -1,619 -3%
AA
70
ALPS Advisors
Colorado
$1.68M +$939 +29 +0.1%
PP
71
PDT Partners
New York
$1.62M – – –
JF
72
Jump Financial
Illinois
$1.58M +$1.34M +41,375 New
Manulife (Manufacturers Life Insurance)
73
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$1.54M +$1.03M +31,867 +381%
RhumbLine Advisers
74
RhumbLine Advisers
Massachusetts
$1.52M +$28.2K +870 +2%
Point72 Asset Management
75
Point72 Asset Management
Connecticut
$1.49M -$27M -835,342 -96%
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TYRA Hedge Fund Activity: Q1 2026 in Review

164 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Tyra Biosciences (TYRA) for Q1 2026, worth a combined $2.52B — up 69% from $1.49B a quarter earlier.

Buyers outnumbered sellers: 46 funds opened new TYRA positions and 14 closed out — a net gain of 32 holders — while 59 added to existing stakes and 35 trimmed.

The largest buyer was Fidelity Investments, adding an estimated $250M. The largest seller was Canaan Partners XI, cutting an estimated $85M.

  • 164 institutional investors held Tyra Biosciences (TYRA) as of Q1 2026, up from 133 in Q4 2025.
  • Funds reported $2.52B of Tyra Biosciences stock for Q1 2026, up 69% quarter-over-quarter.
  • 46 funds opened new Tyra Biosciences positions in Q1 2026 and 14 closed out, a net change of +32 holders.
  • The largest Tyra Biosciences buyer in Q1 2026 was Fidelity Investments, an estimated $250M added.
  • The largest Tyra Biosciences seller in Q1 2026 was Canaan Partners XI, an estimated $85M sold.

Based on aggregated 13F filings for Q1 2026.