Tyra Biosciences
TYRA
133 hedge funds and large institutions have $1.49B invested in Tyra Biosciences in 2025 Q4 according to their latest regulatory filings, with 29 funds opening new positions, 43 increasing their positions, 38 reducing their positions, and 10 closing their positions.
6,580% more call options, than puts
Call options by funds: $334K | Put options by funds: $5K
190% more first-time investments, than exits
New positions opened: 29 | Existing positions closed: 10
140% more funds holding in top 10
Funds holding in top 10: 5 → 12 (+7)
92% more capital invested
Capital invested by funds: $778M → $1.49B (+$716M)
15% more funds holding
Funds holding: 116 → 133 (+17)
13% more repeat investments, than reductions
Existing positions increased: 43 | Existing positions reduced: 38
2.08% more ownership
Funds ownership: 104.39% → 106.47% (+2.1%)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
FCM
Farallon Capital Management
San Francisco,
California
|
+$17M |
| 2 |
Point72 Asset Management
Stamford,
Connecticut
|
+$10.9M |
| 3 |
BCM
Boone Capital Management
Atlanta,
Georgia
|
+$7.32M |
| 4 |
State Street
Boston,
Massachusetts
|
+$5.9M |
| 5 |
CP
Caligan Partners
New York
|
+$4.54M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
BI
BVF Inc
San Francisco,
California
|
-$28M |
| 2 |
KCM
Kynam Capital Management
Princeton,
New Jersey
|
-$14.1M |
| 3 |
APMC
Alta Partners Management Company
Jackson,
Wyoming
|
-$4.72M |
| 4 |
CPX
Canaan Partners XI
Menlo Park,
California
|
-$4.29M |
| 5 |
Walleye Capital
New York
|
-$4.17M |
TYRA Hedge Fund Activity: Q4 2025 in Review
133 of the 8,225 institutional investors tracked by Wall St. Rank reported a position in Tyra Biosciences (TYRA) for Q4 2025, worth a combined $1.49B — up 92% from $778M a quarter earlier.
Buyers outnumbered sellers: 29 funds opened new TYRA positions and 10 closed out — a net gain of 19 holders — while 43 added to existing stakes and 38 trimmed.
The largest buyer was Farallon Capital Management, adding an estimated $17M. The largest seller was BVF Inc, cutting an estimated $28M.
- 133 institutional investors held Tyra Biosciences (TYRA) as of Q4 2025, up from 116 in Q3 2025.
- Funds reported $1.49B of Tyra Biosciences stock for Q4 2025, up 92% quarter-over-quarter.
- 29 funds opened new Tyra Biosciences positions in Q4 2025 and 10 closed out, a net change of +19 holders.
- The largest Tyra Biosciences buyer in Q4 2025 was Farallon Capital Management, an estimated $17M added.
- The largest Tyra Biosciences seller in Q4 2025 was BVF Inc, an estimated $28M sold.
Based on aggregated 13F filings for Q4 2025.