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Spyre Therapeutics
SYRE

Name Holding Trade Value Shares
Change 		Change in
Stake
Fidelity Investments
1
Fidelity Investments
Massachusetts
$381M +$67.4M +2,578,675 +28%
BlackRock
2
BlackRock
New York
$181M +$40.2M +1,539,357 +39%
RI
3
RTW Investments
New York
$137M +$14.4M +550,000 +15%
Vanguard Group
4
Vanguard Group
Pennsylvania
$132M +$25.7M +984,344 +32%
FFM
5
Fairmount Funds Management
Pennsylvania
$132M – – –
VA
6
VR Adviser
New York
$121M +$26.1M +1,000,000 +37%
Capital International Investors
7
Capital International Investors
California
$114M +$28.7M +1,100,000 +46%
PA
8
Perceptive Advisors
New York
$101M +$48.1M +1,839,780 +150%
DCM
9
Driehaus Capital Management
Illinois
$94.4M +$21.5M +822,045 +40%
CC
10
Commodore Capital
New York
$78.2M +$10.5M +400,161 +20%
State Street
11
State Street
Massachusetts
$74.1M +$12.5M +477,633 +27%
TCM
12
TCG Crossover Management
California
$62.3M +$20.9M +800,000 +73%
TCM
13
Tang Capital Management
California
$62M -$34.2M -1,307,800 -41%
Janus Henderson Group
14
Janus Henderson Group
$59.9M +$47.5M +1,816,009 +13,969%
Geode Capital Management
15
Geode Capital Management
Massachusetts
$54.4M +$11.3M +433,987 +35%
B
16
Braidwell
Connecticut
$53.5M -$24.7M -943,789 -37%
RCM
17
RA Capital Management
Massachusetts
$53.1M +$42.4M +1,621,620 New
T. Rowe Price Associates
18
T. Rowe Price Associates
Maryland
$52.5M +$25.6M +981,262 +158%
Wellington Management Group
19
Wellington Management Group
Massachusetts
$50.8M -$2.38M -91,028 -6%
PBA
20
Paradigm Biocapital Advisors
New York
$48.1M – – –
RCP
21
Remedium Capital Partners
Florida
$47.7M +$38.1M +1,456,231 New
AAA
22
Affinity Asset Advisors
New York
$46.9M +$347K +13,292 +0.9%
Franklin Resources
23
Franklin Resources
California
$36.3M +$8.2M +313,999 +39%
BBA
24
Baker Bros. Advisors
New York
$32.8M – – –
Pictet Asset Management
25
Pictet Asset Management
Switzerland
$29.9M -$3.19M -122,258 -12%
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