|
1
|
Alphabet Inc
Mountain View,
California
|
$131M
|
–
|
–
|
–
|
|
|
2
|
PFM Health Sciences
San Francisco,
California
|
$87.6M
|
+$20.2M
|
+836,528
|
+33%
|
|
|
3
|
|
$84.5M
|
+$3.05M
|
+125,809
|
+4%
|
|
|
4
|
BVF Inc
San Francisco,
California
|
$71.4M
|
+$3.75M
|
+155,000
|
+6%
|
|
|
5
|
Vanguard Group
Malvern,
Pennsylvania
|
$60.9M
|
+$3.43M
|
+141,684
|
+6%
|
|
|
6
|
Fidelity Investments
Boston,
Massachusetts
|
$58M
|
-$2.84M
|
-117,282
|
-5%
|
|
|
7
|
EcoR1 Capital
San Francisco,
California
|
$57M
|
+$9.34M
|
+385,892
|
+21%
|
|
|
8
|
Boxer Capital
San Diego,
California
|
$54.1M
|
–
|
–
|
–
|
|
|
9
|
Invus Financial Advisors
New York
|
$47.8M
|
–
|
–
|
–
|
|
|
10
|
State Street
Boston,
Massachusetts
|
$47.3M
|
-$16.8M
|
-695,613
|
-28%
|
|
|
11
|
Ameriprise
Minneapolis,
Minnesota
|
$35.7M
|
+$33.3M
|
+1,376,393
|
New
|
|
|
12
|
Victory Capital Management
San Antonio,
Texas
|
$29.4M
|
-$1.36M
|
-55,997
|
-5%
|
|
|
13
|
Sectoral Asset Management
Montreal,
Quebec, Canada
|
$22.4M
|
-$1.49M
|
-61,640
|
-7%
|
|
|
14
|
TimesSquare Capital Management
New York
|
$21.5M
|
-$569K
|
-23,500
|
-3%
|
|
|
15
|
|
$19.7M
|
+$7.37M
|
+304,495
|
+67%
|
|
|
16
|
Franklin Resources
San Mateo,
California
|
$19M
|
+$533
|
+22
|
+0%
|
|
|
17
|
Geode Capital Management
Boston,
Massachusetts
|
$16.8M
|
+$732K
|
+30,237
|
+5%
|
|
|
18
|
HHLR Advisors
Grand Cayman,
Cayman Islands
|
$16.2M
|
–
|
–
|
–
|
|
|
19
|
|
$14.8M
|
-$1.08M
|
-44,704
|
-7%
|
|
|
20
|
Northern Trust
Chicago,
Illinois
|
$13.9M
|
-$409K
|
-16,883
|
-3%
|
|
|
21
|
|
$12.9M
|
+$1.39M
|
+57,284
|
+13%
|
|
|
22
|
Two Sigma Advisers
New York
|
$12.7M
|
-$1.34M
|
-55,500
|
-10%
|
|
|
23
|
Macquarie Group
Sydney, NSW 2000,
Australia
|
$12M
|
–
|
–
|
–
|
|
|
24
|
Candriam SCA
Strassen, Luxembourg,
Luxembourg
|
$10.6M
|
-$1.93M
|
-79,664
|
-16%
|
|
|
25
|
Alkeon Capital Management
New York
|
$10.6M
|
-$7.45M
|
-307,745
|
-43%
|
|
