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Protagonist Therapeutics
PTGX

Overview Fund Activity

271 hedge funds and large institutions have $3.92B invested in Protagonist Therapeutics in 2025 Q2 according to their latest regulatory filings, with 50 funds opening new positions, 119 increasing their positions, 77 reducing their positions, and 49 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
271
Holders Change
-3
Holders Change %
-1.09%
% of All Funds
3.63%
Holding in Top 10
14
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.19%
New
50
Increased
119
Reduced
77
Closed
49
Calls
$18.4M
Puts
$20.8M
Net Calls
-$2.39M
Net Calls Change
-$21.6M

Top Buyers

1
UBS Group
UBS Group
Switzerland
$138M
2
CC
Commodore Capital
New York
$59.4M
3
Adage Capital Partners
Adage Capital Partners
Massachusetts
$60.4M
4
BI
BVF Inc
California
$177M
5
Holocene Advisors
Holocene Advisors
New York
$29.3M

Top Sellers

1
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
$51.8M
2
Focus Partners Wealth
Focus Partners Wealth
Massachusetts
$0
3
NVCHI
New Vernon Capital Holdings II
New Jersey
$398K
4
AGP
Artia Global Partners
Florida
$1.27M
5
Qube Research & Technologies (QRT)
Qube Research & Technologies (QRT)
United Kingdom
$3.81M
Name Holding Trade Value Shares
Change 		Shares
Change %
CIP
201
Cornerstone Investment Partners
Georgia
$275K +$166 +3 +0.1%
GCM
202
Graham Capital Management
Connecticut
$275K +$275K +4,979 New
LPL Financial
203
LPL Financial
California
$266K -$3.87K -70 -1%
AAM
204
Advisors Asset Management
Colorado
$261K +$166 +3 +0.1%
BC
205
Bridgefront Capital
Texas
$251K +$251K +4,545 New
X
206
Xponance
Pennsylvania
$249K +$2.32K +42 +0.9%
HSBC Holdings
207
HSBC Holdings
United Kingdom
$242K -$230K -4,118 -49%
CGH
208
Crossmark Global Holdings
Texas
$225K +$225K +4,065 New
SOW
209
State of Wyoming
Wyoming
$220K +$140K +2,528 +174%
Nisa Investment Advisors
210
Nisa Investment Advisors
Missouri
$216K +$59.2K +1,071 +38%
VCIM
211
Velan Capital Investment Management
Georgia
$204K +$204K +3,700 New
WC
212
Wexford Capital
Florida
$183K +$183K +3,315 New
NS
213
NBC Securities
Alabama
$141K +$141K +2,565 New
PNC Financial Services Group
214
PNC Financial Services Group
Pennsylvania
$133K +$23.3K +422 +21%
Mirae Asset Global Investments
215
Mirae Asset Global Investments
South Korea
$132K +$18.8K +340 +17%
SG Americas Securities
216
SG Americas Securities
New York
$106K +$106K +1,924 New
C
217
Covestor
United Kingdom
$97K -$19K -342 -16%
VIA
218
Virtus Investment Advisers
Connecticut
$92.3K -$132K -2,395 -59%
KBC Group
219
KBC Group
Belgium
$87K -$28.7K -519 -25%
GFM
220
GF Fund Management
China
$84.3K – – –
SAM
221
Smartleaf Asset Management
Massachusetts
$70K +$2.56K +46 +4%
GI
222
GAMMA Investing
California
$59.5K -$6.96K -126 -10%
TC
223
Truvestments Capital
Florida
$35.9K +$20.4K +369 +131%
Carson Wealth (CWM LLC)
224
Carson Wealth (CWM LLC)
Nebraska
$34K +$22.7K +407 +201%
Bessemer Group
225
Bessemer Group
New Jersey
$28K +$17.7K +318 +171%
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9
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