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Protagonist Therapeutics

312 hedge funds and large institutions have $6.18B invested in Protagonist Therapeutics in 2025 Q4 according to their latest regulatory filings, with 81 funds opening new positions, 97 increasing their positions, 103 reducing their positions, and 39 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more capital invested

Capital invested by funds: $ → $

more funds holding in top 10

Funds holding in top 10:

14% more funds holding

Funds holding: 274312 (+38)

0.49% less ownership

Funds ownership: 113.62%113.13% (-0.49%)

6% less repeat investments, than reductions

Existing positions increased: 97 | Existing positions reduced: 103

Holders
312
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
13
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$85.2M
Puts
$4.57M
Net Calls
Net Calls Change

Top Buyers

1 +$127M
2 +$103M
3 +$94.7M
4
Citadel Advisors
Citadel Advisors
Florida
+$72.7M
5
UBS Group
UBS Group
Switzerland
+$71.5M

Top Sellers

1 -$170M
2 -$114M
3 -$66.8M
4
RI
RTW Investments
New York
-$57.1M
5
CC
Commodore Capital
New York
-$47.1M
Name Holding Trade Value Shares
Change
Change in
Stake
CIP
201
Cornerstone Investment Partners
Georgia
$405K
X
202
Xponance
Pennsylvania
$401K
Ensign Peak Advisors
203
Ensign Peak Advisors
Utah
$392K
BCI
204
Brinker Capital Investments
Pennsylvania
$384K
US Bancorp
205
US Bancorp
Minnesota
$384K
OSAM
206
O'Shaughnessy Asset Management
Connecticut
$382K
BIG
207
Brooklyn Investment Group
New York
$381K
Los Angeles Capital Management
208
Los Angeles Capital Management
California
$368K
Osaic Holdings
209
Osaic Holdings
Arizona
$367K
VA
210
Vident Advisory
Georgia
$366K
NVCHI
211
New Vernon Capital Holdings II
New Jersey
$361K
KWMG
212
King Wealth Management Group
Florida
$349K
Allspring Global Investments
213
Allspring Global Investments
North Carolina
$347K
CGH
214
Crossmark Global Holdings
Texas
$346K
CWM
215
CIBC World Markets
New York
$336K
Bank of Montreal
216
Bank of Montreal
Ontario, Canada
$332K
Nisa Investment Advisors
217
Nisa Investment Advisors
Missouri
$330K
VI
218
Vestcor Inc
New Brunswick, Canada
$329K
AWP
219
Abacus Wealth Partners
California
$329K
M&T Bank
220
M&T Bank
New York
$328K
VCIM
221
Velan Capital Investment Management
Georgia
$323K
BC
222
Burney Company
Virginia
$321K
Mackenzie Financial
223
Mackenzie Financial
Ontario, Canada
$318K
VPIM
224
Vanguard Personalized Indexing Management
California
$312K
Wealth Enhancement Advisory Services
225
Wealth Enhancement Advisory Services
Minnesota
$292K