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Protagonist Therapeutics
PTGX

Overview Fund Activity

271 hedge funds and large institutions have $3.92B invested in Protagonist Therapeutics in 2025 Q2 according to their latest regulatory filings, with 50 funds opening new positions, 119 increasing their positions, 77 reducing their positions, and 49 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
271
Holders Change
-3
Holders Change %
-1.09%
% of All Funds
3.63%
Holding in Top 10
14
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.19%
New
50
Increased
119
Reduced
77
Closed
49
Calls
$18.4M
Puts
$20.8M
Net Calls
-$2.39M
Net Calls Change
-$21.6M

Top Buyers

1
UBS Group
UBS Group
Switzerland
$138M
2
CC
Commodore Capital
New York
$59.4M
3
Adage Capital Partners
Adage Capital Partners
Massachusetts
$60.4M
4
BI
BVF Inc
California
$177M
5
Holocene Advisors
Holocene Advisors
New York
$29.3M

Top Sellers

1
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
$51.8M
2
Focus Partners Wealth
Focus Partners Wealth
Massachusetts
$0
3
NVCHI
New Vernon Capital Holdings II
New Jersey
$398K
4
AGP
Artia Global Partners
Florida
$1.27M
5
Qube Research & Technologies (QRT)
Qube Research & Technologies (QRT)
United Kingdom
$3.81M
Name Holding Trade Value Shares
Change 		Shares
Change %
AGWCA
251
Annis Gardner Whiting Capital Advisors
Florida
$4.2K +$4.2K +76 New
RAM
252
Riggs Asset Management
Pennsylvania
$3.93K +$3.93K +71 New
IA
253
IFP Advisors
Florida
$3.1K – – –
KIM
254
Kestra Investment Management
Texas
$2.8K +$1.4K +27 +100%
GWM
255
Geneos Wealth Management
Colorado
$2.6K +$608 +11 +31%
PFBT
256
Parkside Financial Bank & Trust
Missouri
$2.49K +$608 +11 +32%
CIAM
257
Caitong International Asset Management
Hong Kong
$2.27K -$152K -2,747 -99%
HNB
258
Huntington National Bank
Ohio
$2.16K +$2.16K +39 New
PS
259
Principal Securities
Iowa
$1.99K +$1.33K +24 +200%
WWM
260
Wolff Wiese Magana
California
$1.94K – – –
FMII
261
Farmers & Merchants Investments Inc
Nebraska
$1.93K – – –
VCM
262
Versant Capital Management
Arizona
$1.6K +$1.6K +29 New
LFG
263
Larson Financial Group
Missouri
$1.44K -$5.53K -100 -79%
BFS
264
Bare Financial Services
Pennsylvania
$1.27K +$1.27K +23 New
WA
265
Whipplewood Advisors
Colorado
$1.22K +$1.22K +22 New
CT
266
Clearstead Trust
Maine
$1.16K +$1.16K +21 New
Jones Financial Companies
267
Jones Financial Companies
Missouri
$1.11K +$1.11K +20 New
PMAM
268
Picton Mahoney Asset Management
Ontario, Canada
$1K – – –
PWA
269
Physician Wealth Advisors
Utah
$498 +$498 +9 New
AWM
270
Abound Wealth Management
Tennessee
$222 – – –
KG
271
Kilter Group
New York
$222 +$222 +4 New
DF
272
DecisionPoint Financial
Arizona
$201 +$201 +4 New
Focus Partners Wealth
273
Focus Partners Wealth
Massachusetts
– -$21M -435,097 Closed
Jane Street
274
Jane Street
New York
– -$9.35M -193,300 Closed
SCM
275
Soleus Capital Management
Connecticut
– -$8.17M -169,000 Closed
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