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Protagonist Therapeutics

312 hedge funds and large institutions have $6.18B invested in Protagonist Therapeutics in 2025 Q4 according to their latest regulatory filings, with 81 funds opening new positions, 97 increasing their positions, 103 reducing their positions, and 39 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more capital invested

Capital invested by funds: $ → $

more funds holding in top 10

Funds holding in top 10:

14% more funds holding

Funds holding: 274312 (+38)

0.49% less ownership

Funds ownership: 113.62%113.13% (-0.49%)

6% less repeat investments, than reductions

Existing positions increased: 97 | Existing positions reduced: 103

Holders
312
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
13
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$85.2M
Puts
$4.57M
Net Calls
Net Calls Change

Top Buyers

1 +$127M
2 +$103M
3 +$94.7M
4
Citadel Advisors
Citadel Advisors
Florida
+$72.7M
5
UBS Group
UBS Group
Switzerland
+$71.5M

Top Sellers

1 -$170M
2 -$114M
3 -$66.8M
4
RI
RTW Investments
New York
-$57.1M
5
CC
Commodore Capital
New York
-$47.1M
Name Holding Trade Value Shares
Change
Change in
Stake
Rockefeller Capital Management
226
Rockefeller Capital Management
New York
$288K
LPL Financial
227
LPL Financial
California
$285K
C
228
Certuity
Florida
$284K
Royal Bank of Canada
229
Royal Bank of Canada
Ontario, Canada
$278K
Mirae Asset Global Investments
230
Mirae Asset Global Investments
South Korea
$265K
VT
231
Vise Technologies
New York
$262K
NS
232
NBC Securities
Alabama
$260K
PNC Financial Services Group
233
PNC Financial Services Group
Pennsylvania
$258K
PWPS
234
Pinnacle Wealth Planning Services
Ohio
$250K
ECM
235
Evergreen Capital Management
Washington
$246K
VIA
236
Virtus Investment Advisers
Connecticut
$244K
NAAA
237
New Age Alpha Advisors
New York
$243K
CAPTRUST Financial Advisors
238
CAPTRUST Financial Advisors
North Carolina
$239K
GI
239
GAMMA Investing
California
$233K
CIBC Asset Management
240
CIBC Asset Management
Ontario, Canada
$233K
Sumitomo Mitsui Trust Group
241
Sumitomo Mitsui Trust Group
Japan
$224K
HCMT
242
Highland Capital Management (Tennessee)
Tennessee
$215K
SLAM
243
Swiss Life Asset Management
$212K
SOW
244
State of Wyoming
Wyoming
$181K
TRCT
245
Tower Research Capital (TRC)
New York
$179K
SAM
246
Smartleaf Asset Management
Massachusetts
$151K
A
247
AlphaQuest
New York
$141K
KBC Group
248
KBC Group
Belgium
$137K
QCG
249
Quadrant Capital Group
Ohio
$128K
C
250
Covestor
United Kingdom
$125K