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Protagonist Therapeutics
PTGX

Overview Fund Activity

271 hedge funds and large institutions have $3.92B invested in Protagonist Therapeutics in 2025 Q2 according to their latest regulatory filings, with 50 funds opening new positions, 119 increasing their positions, 77 reducing their positions, and 49 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
271
Holders Change
-3
Holders Change %
-1.09%
% of All Funds
3.63%
Holding in Top 10
14
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.19%
New
50
Increased
119
Reduced
77
Closed
49
Calls
$18.4M
Puts
$20.8M
Net Calls
-$2.39M
Net Calls Change
-$21.6M

Top Buyers

1
UBS Group
UBS Group
Switzerland
$138M
2
CC
Commodore Capital
New York
$59.4M
3
Adage Capital Partners
Adage Capital Partners
Massachusetts
$60.4M
4
BI
BVF Inc
California
$177M
5
Holocene Advisors
Holocene Advisors
New York
$29.3M

Top Sellers

1
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
$51.8M
2
Focus Partners Wealth
Focus Partners Wealth
Massachusetts
$0
3
NVCHI
New Vernon Capital Holdings II
New Jersey
$398K
4
AGP
Artia Global Partners
Florida
$1.27M
5
Qube Research & Technologies (QRT)
Qube Research & Technologies (QRT)
United Kingdom
$3.81M
Name Holding Trade Value Shares
Change 		Shares
Change %
FIA
226
FNY Investment Advisers
New York
$27K +$27K +500 New
BIG
227
Brooklyn Investment Group
New York
$26.9K -$50.5K -913 -65%
Osaic Holdings
228
Osaic Holdings
Arizona
$26.3K -$10.2K -185 -28%
GRP
229
Global Retirement Partners
California
$17.5K +$17.5K +316 New
AssetMark Inc
230
AssetMark Inc
California
$16K -$276 -5 -2%
EWA
231
EverSource Wealth Advisors
Alabama
$12.5K +$7.57K +137 +154%
RA
232
Rise Advisors
New York
$12.4K – – –
Daiwa Securities Group
233
Daiwa Securities Group
Japan
$12K – – –
Fifth Third Bancorp
234
Fifth Third Bancorp
Ohio
$11.7K -$3.92K -71 -25%
UB
235
UMB Bank
Missouri
$11K +$2.27K +41 +26%
TPWA
236
Twin Peaks Wealth Advisors
California
$9.33K +$9.33K +171 New
S
237
SignatureFD
Georgia
$8.24K +$3.04K +55 +59%
HFS
238
Hantz Financial Services
Michigan
$8K +$7.89K +141 +7,050%
SCM
239
Sterling Capital Management
North Carolina
$7.9K +$4.42K +80 +127%
Russell Investments Group
240
Russell Investments Group
United Kingdom
$7.13K -$178K -3,229 -96%
MPWT
241
MassMutual Private Wealth & Trust
Connecticut
$6.58K +$4.09K +74 +164%
AF
242
Allworth Financial
California
$6.47K +$4.81K +87 +290%
CA
243
Clearstead Advisors
Ohio
$6.08K – – –
RIL
244
Rothschild Investment LLC
Illinois
$6.08K +$829 +15 +16%
PA
245
Parallel Advisors
California
$5.36K +$3.87K +70 +259%
FFA
246
Farther Finance Advisors
California
$5.14K -$16.4K -296 -76%
MCM
247
MAI Capital Management
Ohio
$4.75K +$4.75K +86 New
BIA
248
Bell Investment Advisors
California
$4.48K +$2.76K +50 +161%
BBHC
249
Brown Brothers Harriman & Co
New York
$4.48K +$4.48K +81 New
WA
250
WPG Advisers
Maryland
$4.31K +$3.87K +70 +875%
8 9
10
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