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Protagonist Therapeutics

312 hedge funds and large institutions have $6.18B invested in Protagonist Therapeutics in 2025 Q4 according to their latest regulatory filings, with 81 funds opening new positions, 97 increasing their positions, 103 reducing their positions, and 39 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more capital invested

Capital invested by funds: $ → $

more funds holding in top 10

Funds holding in top 10:

14% more funds holding

Funds holding: 274312 (+38)

0.49% less ownership

Funds ownership: 113.62%113.13% (-0.49%)

6% less repeat investments, than reductions

Existing positions increased: 97 | Existing positions reduced: 103

Holders
312
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
13
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$85.2M
Puts
$4.57M
Net Calls
Net Calls Change

Top Buyers

1 +$127M
2 +$103M
3 +$94.7M
4
Citadel Advisors
Citadel Advisors
Florida
+$72.7M
5
UBS Group
UBS Group
Switzerland
+$71.5M

Top Sellers

1 -$170M
2 -$114M
3 -$66.8M
4
RI
RTW Investments
New York
-$57.1M
5
CC
Commodore Capital
New York
-$47.1M
Name Holding Trade Value Shares
Change
Change in
Stake
Tudor Investment Corp
176
Tudor Investment Corp
Connecticut
$674K
Mariner
177
Mariner
Kansas
$666K
HI
178
Horizon Investments
North Carolina
$652K
Teacher Retirement System of Texas
179
Teacher Retirement System of Texas
Texas
$642K
HighTower Advisors
180
HighTower Advisors
Illinois
$622K
CIM
181
Cambria Investment Management
California
$608K
AQR Capital Management
182
AQR Capital Management
Connecticut
$607K
MOACM
183
Mutual of America Capital Management
New York
$587K
FRM
184
Fox Run Management
Connecticut
$581K
PWM
185
Palumbo Wealth Management
New York
$554K
PR
186
PSP Research
Pennsylvania
$535K
Public Employees Retirement Association of Colorado
187
Public Employees Retirement Association of Colorado
Colorado
$524K
CG
188
Caprock Group
Idaho
$523K
FCM
189
Fieldview Capital Management
Michigan
$510K
Russell Investments Group
190
Russell Investments Group
United Kingdom
$500K
Aviva
191
Aviva
United Kingdom
$490K
DekaBank Deutsche Girozentrale
192
DekaBank Deutsche Girozentrale
Germany
$489K
KAS
193
Kestra Advisory Services
Texas
$449K
AG
194
Algert Global
California
$445K
Arrowstreet Capital
195
Arrowstreet Capital
Massachusetts
$443K
JFG
196
Jefferies Financial Group
New York
$437K
TCA
197
Taconic Capital Advisors
New York
$437K
QCM
198
Quantinno Capital Management
New York
$432K
AIP
199
Ameritas Investment Partners
Nebraska
$413K
AAM
200
Advisors Asset Management
Colorado
$411K