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Protagonist Therapeutics
PTGX

Overview Fund Activity

271 hedge funds and large institutions have $3.92B invested in Protagonist Therapeutics in 2025 Q2 according to their latest regulatory filings, with 50 funds opening new positions, 119 increasing their positions, 77 reducing their positions, and 49 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
271
Holders Change
-3
Holders Change %
-1.09%
% of All Funds
3.63%
Holding in Top 10
14
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.19%
New
50
Increased
119
Reduced
77
Closed
49
Calls
$18.4M
Puts
$20.8M
Net Calls
-$2.39M
Net Calls Change
-$21.6M

Top Buyers

1
UBS Group
UBS Group
Switzerland
$138M
2
CC
Commodore Capital
New York
$59.4M
3
Adage Capital Partners
Adage Capital Partners
Massachusetts
$60.4M
4
BI
BVF Inc
California
$177M
5
Holocene Advisors
Holocene Advisors
New York
$29.3M

Top Sellers

1
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
$51.8M
2
Focus Partners Wealth
Focus Partners Wealth
Massachusetts
$0
3
NVCHI
New Vernon Capital Holdings II
New Jersey
$398K
4
AGP
Artia Global Partners
Florida
$1.27M
5
Qube Research & Technologies (QRT)
Qube Research & Technologies (QRT)
United Kingdom
$3.81M
Name Holding Trade Value Shares
Change 		Shares
Change %
Simplex Trading
176
Simplex Trading
Illinois
$522K -$910K -16,482 -64%
Aviva
177
Aviva
United Kingdom
$521K -$208K -3,765 -29%
BNP Paribas Financial Markets
178
BNP Paribas Financial Markets
France
$505K -$278K -5,030 -36%
EFM
179
E Fund Management
China
$497K +$268K +4,853 +117%
CIM
180
Cambria Investment Management
California
$484K -$13.4K -243 -3%
Pathstone Holdings
181
Pathstone Holdings
New Jersey
$453K +$453K +8,195 New
MOACM
182
Mutual of America Capital Management
New York
$440K -$39.6K -717 -8%
PWM
183
Palumbo Wealth Management
New York
$416K +$416K +7,530 New
Nomura Holdings
184
Nomura Holdings
Japan
$410K +$410K +7,416 New
XT
185
XTX Topco
Cayman Islands
$405K -$383K -6,925 -49%
II
186
Inspire Investing
Idaho
$403K -$804K -14,550 -67%
NVCHI
187
New Vernon Capital Holdings II
New Jersey
$398K -$18.8M -340,897 -98%
CWM
188
CIBC World Markets
New York
$396K -$332K -6,005 -46%
Capstone Investment Advisors
189
Capstone Investment Advisors
New York
$386K +$386K +6,987 New
AACP
190
Advantage Alpha Capital Partners
California
$385K -$91.9K -1,662 -19%
BCI
191
Brinker Capital Investments
Pennsylvania
$365K -$7.24K -131 -2%
BC
192
Burney Company
Virginia
$349K -$10.8M -195,667 -97%
BPC
193
Bryce Point Capital
New York
$343K +$343K +6,200 New
KWMG
194
King Wealth Management Group
Florida
$332K – – –
Mitsubishi UFJ Trust & Banking
195
Mitsubishi UFJ Trust & Banking
Japan
$330K +$330K +5,975 New
AIP
196
Ameritas Investment Partners
Nebraska
$327K – – –
NWAG
197
Net Worth Advisory Group
Utah
$322K +$322K +5,822 New
KAS
198
Kestra Advisory Services
Texas
$319K +$32.2K +582 +11%
TRCT
199
Tower Research Capital (TRC)
New York
$295K +$282K +5,108 +2,211%
US Bancorp
200
US Bancorp
Minnesota
$289K +$86.7K +1,569 +43%
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