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Protagonist Therapeutics

312 hedge funds and large institutions have $6.18B invested in Protagonist Therapeutics in 2025 Q4 according to their latest regulatory filings, with 81 funds opening new positions, 97 increasing their positions, 103 reducing their positions, and 39 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more capital invested

Capital invested by funds: $ → $

more funds holding in top 10

Funds holding in top 10:

14% more funds holding

Funds holding: 274312 (+38)

0.49% less ownership

Funds ownership: 113.62%113.13% (-0.49%)

6% less repeat investments, than reductions

Existing positions increased: 97 | Existing positions reduced: 103

Holders
312
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
13
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$85.2M
Puts
$4.57M
Net Calls
Net Calls Change

Top Buyers

1 +$127M
2 +$103M
3 +$94.7M
4
Citadel Advisors
Citadel Advisors
Florida
+$72.7M
5
UBS Group
UBS Group
Switzerland
+$71.5M

Top Sellers

1 -$170M
2 -$114M
3 -$66.8M
4
RI
RTW Investments
New York
-$57.1M
5
CC
Commodore Capital
New York
-$47.1M
Name Holding Trade Value Shares
Change
Change in
Stake
IIM
126
INTECH Investment Management
Florida
$1.96M
State of Tennessee, Department of Treasury
127
State of Tennessee, Department of Treasury
Tennessee
$1.92M
O
128
OrbiMed
New York
$1.9M
GAM
129
Gotham Asset Management
New York
$1.89M
CCIA
130
Campbell & Co Investment Adviser
Maryland
$1.84M
Natixis Advisors
131
Natixis Advisors
Massachusetts
$1.79M
Polen Capital Management
132
Polen Capital Management
Florida
$1.78M
SG Americas Securities
133
SG Americas Securities
New York
$1.75M
Handelsbanken Fonder
134
Handelsbanken Fonder
Sweden
$1.74M
New York State Common Retirement Fund
135
New York State Common Retirement Fund
New York
$1.61M
Nomura Holdings
136
Nomura Holdings
Japan
$1.53M
Millennium Management
137
Millennium Management
New York
$1.52M
HT
138
Headlands Technologies
Illinois
$1.49M
AB
139
Amalgamated Bank
New York
$1.49M
RA
140
Royce & Associates
New York
$1.48M
State of New Jersey Common Pension Fund D
141
State of New Jersey Common Pension Fund D
New Jersey
$1.48M
BG
142
Bellevue Group
Switzerland
$1.44M
Pathstone Holdings
143
Pathstone Holdings
New Jersey
$1.44M
State Board of Administration of Florida Retirement System
144
State Board of Administration of Florida Retirement System
Florida
$1.42M
SO
145
STRS Ohio
Ohio
$1.39M
PFSRSONJ
146
Police & Firemen's Retirement System of New Jersey
New Jersey
$1.38M
YCM
147
Yousif Capital Management
Michigan
$1.36M
Envestnet Asset Management
148
Envestnet Asset Management
Illinois
$1.28M
COPPSERS
149
Commonwealth of Pennsylvania Public School Employees Retirement System
Pennsylvania
$1.27M
ProShare Advisors
150
ProShare Advisors
Maryland
$1.23M