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Protagonist Therapeutics
PTGX

Overview Fund Activity

271 hedge funds and large institutions have $3.92B invested in Protagonist Therapeutics in 2025 Q2 according to their latest regulatory filings, with 50 funds opening new positions, 119 increasing their positions, 77 reducing their positions, and 49 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
271
Holders Change
-3
Holders Change %
-1.09%
% of All Funds
3.63%
Holding in Top 10
14
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.19%
New
50
Increased
119
Reduced
77
Closed
49
Calls
$18.4M
Puts
$20.8M
Net Calls
-$2.39M
Net Calls Change
-$21.6M

Top Buyers

1
UBS Group
UBS Group
Switzerland
$138M
2
CC
Commodore Capital
New York
$59.4M
3
Adage Capital Partners
Adage Capital Partners
Massachusetts
$60.4M
4
BI
BVF Inc
California
$177M
5
Holocene Advisors
Holocene Advisors
New York
$29.3M

Top Sellers

1
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
$51.8M
2
Focus Partners Wealth
Focus Partners Wealth
Massachusetts
$0
3
NVCHI
New Vernon Capital Holdings II
New Jersey
$398K
4
AGP
Artia Global Partners
Florida
$1.27M
5
Qube Research & Technologies (QRT)
Qube Research & Technologies (QRT)
United Kingdom
$3.81M
Name Holding Trade Value Shares
Change 		Shares
Change %
AGP
126
Artia Global Partners
Florida
$1.27M -$17.2M -310,900 -93%
HI
127
Horizon Investments
North Carolina
$1.24M +$1.24M +22,470 New
Mackenzie Financial
128
Mackenzie Financial
Ontario, Canada
$1.24M -$13.3K -241 -1%
Allianz Asset Management
129
Allianz Asset Management
Germany
$1.23M +$879K +15,900 +248%
GIM
130
Glenmede Investment Management
Pennsylvania
$1.18M +$1.18M +21,434 New
Comerica Bank
131
Comerica Bank
Texas
$1.18M +$58K +1,050 +5%
FCM
132
Fieldview Capital Management
Michigan
$1.13M +$1.13M +20,381 New
SO
133
STRS Ohio
Ohio
$1.08M +$33.2K +600 +3%
New York State Common Retirement Fund
134
New York State Common Retirement Fund
New York
$1.08M – – –
BG
135
Bellevue Group
Switzerland
$1.08M +$102K +1,850 +10%
GC
136
Guggenheim Capital
Illinois
$1.06M +$16.7K +303 +2%
PA
137
Profund Advisors
Maryland
$1.05M +$415K +7,515 +65%
VRS
138
Virginia Retirement Systems
Virginia
$1.05M +$77.4K +1,400 +8%
CUAMC
139
China Universal Asset Management Company
China
$1.05M +$7.52K +136 +0.7%
TRSOTSOK
140
Teachers Retirement System of the State of Kentucky
Kentucky
$1.04M -$81.2K -1,468 -7%
MSRPS
141
Maryland State Retirement & Pension System
Maryland
$1.01M +$45.2K +818 +5%
Arrowstreet Capital
142
Arrowstreet Capital
Massachusetts
$987K +$987K +17,856 New
AB
143
Amalgamated Bank
New York
$970K +$33.5K +605 +4%
PAP
144
Persistent Asset Partners
Hong Kong
$968K +$968K +17,520 New
WG
145
Winton Group
United Kingdom
$964K -$186K -3,362 -16%
AQR Capital Management
146
AQR Capital Management
Connecticut
$962K -$1.25M -22,678 -57%
Handelsbanken Fonder
147
Handelsbanken Fonder
Sweden
$940K +$144K +2,600 +18%
SC
148
Stempoint Capital
New York
$927K -$1.79M -32,471 -66%
State Board of Administration of Florida Retirement System
149
State Board of Administration of Florida Retirement System
Florida
$901K – – –
Polen Capital Management
150
Polen Capital Management
Florida
$884K +$884K +15,999 New
4 5
6
7 8