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Protagonist Therapeutics
PTGX

Overview Fund Activity

270 hedge funds and large institutions have $3.92B invested in Protagonist Therapeutics in 2025 Q2 according to their latest regulatory filings, with 50 funds opening new positions, 119 increasing their positions, 76 reducing their positions, and 49 closing their positions.

Holders
270
Holders Change
-4
Holders Change %
-1.46%
% of All Funds
3.62%
Holding in Top 10
14
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.19%
New
50
Increased
119
Reduced
76
Closed
49
Calls
$11.6M
Puts
$15.9M
Net Calls
-$4.31M
Net Calls Change
-$23.5M

Top Buyers

1
UBS Group
1
UBS Group
Switzerland
$138M
2
CC
2
Commodore Capital
New York
$59.4M
3
Adage Capital Partners
3
Adage Capital Partners
Massachusetts
$60.4M
4
BI
4
BVF Inc
California
$177M
5
Holocene Advisors
5
Holocene Advisors
New York
$29.3M

Top Sellers

1
T. Rowe Price Associates
1
T. Rowe Price Associates
Maryland
$51.8M
2
Focus Partners Wealth
2
Focus Partners Wealth
Massachusetts
$0
3
NVCHI
3
New Vernon Capital Holdings II
New Jersey
$398K
4
AGP
4
Artia Global Partners
Florida
$1.27M
5
Qube Research & Technologies (QRT)
5
Qube Research & Technologies (QRT)
United Kingdom
$3.81M
Name Market Value Shares Shares
Change 		Shares
Change %
Citigroup
76
Citigroup
New York
$4.31M 77,951 -43,893 -36%
Prudential Financial
77
Prudential Financial
New Jersey
$4.28M 77,408 +19,050 +33%
SSA
78
Schonfeld Strategic Advisors
New York
$4.26M 77,068 -210,233 -73%
DP
79
Diadema Partners
New Jersey
$4.21M 76,185 +76,185 New
Royal Bank of Canada
80
Royal Bank of Canada
Ontario, Canada
$4.13M 74,734 +64,770 +650%
EI
81
EAM Investors
California
$3.98M 71,971 +2,790 +4%
EGI
82
EAM Global Investors
California
$3.85M 69,726 -24 -0%
Qube Research & Technologies (QRT)
83
Qube Research & Technologies (QRT)
United Kingdom
$3.81M 68,983 -274,428 -80%
AllianceBernstein
84
AllianceBernstein
Tennessee
$3.75M 67,900 – –
PHP
85
Parkman Healthcare Partners
Connecticut
$3.4M 61,596 +61,596 New
BCM
86
Boxer Capital Management
California
$3.32M 60,000 +60,000 New
HS
87
HighVista Strategies
Massachusetts
$3.2M 57,851 -20,601 -26%
New York State Teachers Retirement System (NYSTRS)
88
New York State Teachers Retirement System (NYSTRS)
New York
$3.08M 55,713 +8,858 +19%
SAM
89
Silvercrest Asset Management
New York
$3.02M 54,723 – –
AI
90
Axiom Investors
Connecticut
$2.83M 51,233 +11,264 +28%
California State Teachers Retirement System (CalSTRS)
91
California State Teachers Retirement System (CalSTRS)
California
$2.83M 51,195 +9,339 +22%
Canada Life
92
Canada Life
Manitoba, Canada
$2.78M 50,242 -713 -1%
Capital Fund Management (CFM)
93
Capital Fund Management (CFM)
France
$2.75M 49,805 +49,805 New
BC
94
Birchview Capital
Vermont
$2.65M 48,000 -2 -0%
ETC
95
Exchange Traded Concepts
Oklahoma
$2.62M 47,391 +19,999 +73%
Thrivent Financial for Lutherans
96
Thrivent Financial for Lutherans
Minnesota
$2.52M 45,576 +1,800 +4%
SEI Investments
97
SEI Investments
Pennsylvania
$2.48M 44,932 +7,404 +20%
N
98
Natixis
France
$2.32M 42,040 +42,040 New
ACM
99
Aquatic Capital Management
Illinois
$2.32M 42,000 +26,893 +178%
Wells Fargo
100
Wells Fargo
California
$2.3M 41,687 +1,878 +5%
2 3
4
5 6