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Protagonist Therapeutics

272 hedge funds and large institutions have $4.7B invested in Protagonist Therapeutics in 2025 Q3 according to their latest regulatory filings, with 44 funds opening new positions, 83 increasing their positions, 109 reducing their positions, and 38 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more capital invested

Capital invested by funds: $ → $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

0.9% less ownership

Funds ownership: 114.51%113.62% (-0.9%)

24% less repeat investments, than reductions

Existing positions increased: 83 | Existing positions reduced: 109

29% less funds holding in top 10

Funds holding in top 10: 1410 (-4)

Holders
272
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
10
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$12.2M
Puts
$3.45M
Net Calls
Net Calls Change
Name Holding Trade Value Shares
Change
Change in
Stake
DMKJ
76
David M. Knott Jr
$5.51M
ACM
77
Atika Capital Management
New York
$5.51M
Franklin Resources
78
Franklin Resources
California
$5.51M
EAM
79
EFG Asset Management
Oregon
$5.49M
AI
80
Axiom Investors
Connecticut
$5.32M
Skandinaviska Enskilda Banken (SEB)
81
Skandinaviska Enskilda Banken (SEB)
Sweden
$5.23M
EI
82
EAM Investors
California
$5.23M
Rafferty Asset Management
83
Rafferty Asset Management
New York
$4.97M
Royal Bank of Canada
84
Royal Bank of Canada
Ontario, Canada
$4.65M
Assenagon Asset Management
85
Assenagon Asset Management
Luxembourg
$4.37M
Susquehanna International Group
86
Susquehanna International Group
Pennsylvania
$4.2M
First Trust Advisors
87
First Trust Advisors
Illinois
$4.17M
PHP
88
Parkman Healthcare Partners
Connecticut
$4.11M
Northwestern Mutual Wealth Management
89
Northwestern Mutual Wealth Management
Wisconsin
$3.91M
SAM
90
Silvercrest Asset Management
New York
$3.54M
DP
91
Diadema Partners
New Jersey
$3.4M
New York State Teachers Retirement System (NYSTRS)
92
New York State Teachers Retirement System (NYSTRS)
New York
$3.29M
BC
93
Birchview Capital
Vermont
$3.19M
SC
94
Stempoint Capital
New York
$3.19M
Wells Fargo
95
Wells Fargo
California
$3.17M
California State Teachers Retirement System (CalSTRS)
96
California State Teachers Retirement System (CalSTRS)
California
$3.15M
Canada Life
97
Canada Life
Manitoba, Canada
$3.15M
Jane Street
98
Jane Street
New York
$2.95M
SEI Investments
99
SEI Investments
Pennsylvania
$2.92M
Thrivent Financial for Lutherans
100
Thrivent Financial for Lutherans
Minnesota
$2.8M