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Protagonist Therapeutics
PTGX

Overview Fund Activity

270 hedge funds and large institutions have $3.92B invested in Protagonist Therapeutics in 2025 Q2 according to their latest regulatory filings, with 50 funds opening new positions, 119 increasing their positions, 76 reducing their positions, and 49 closing their positions.

Holders
270
Holders Change
-4
Holders Change %
-1.46%
% of All Funds
3.62%
Holding in Top 10
14
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.19%
New
50
Increased
119
Reduced
76
Closed
49
Calls
$11.6M
Puts
$15.9M
Net Calls
-$4.31M
Net Calls Change
-$23.5M

Top Buyers

1
UBS Group
1
UBS Group
Switzerland
$138M
2
CC
2
Commodore Capital
New York
$59.4M
3
Adage Capital Partners
3
Adage Capital Partners
Massachusetts
$60.4M
4
BI
4
BVF Inc
California
$177M
5
Holocene Advisors
5
Holocene Advisors
New York
$29.3M

Top Sellers

1
T. Rowe Price Associates
1
T. Rowe Price Associates
Maryland
$51.8M
2
Focus Partners Wealth
2
Focus Partners Wealth
Massachusetts
$0
3
NVCHI
3
New Vernon Capital Holdings II
New Jersey
$398K
4
AGP
4
Artia Global Partners
Florida
$1.27M
5
Qube Research & Technologies (QRT)
5
Qube Research & Technologies (QRT)
United Kingdom
$3.81M
Name Market Value Shares Shares
Change 		Shares
Change %
Ameriprise
51
Ameriprise
Minnesota
$9.31M 168,371 +31,529 +23%
Legal & General Group
52
Legal & General Group
United Kingdom
$9.18M 166,181 +18,074 +12%
PAM
53
Panagora Asset Management
Massachusetts
$8.22M 148,790 -1,118 -0.7%
GLA
54
Great Lakes Advisors
Illinois
$7.7M 139,391 -12,927 -8%
NFT
55
Nan Fung Trinity
Hong Kong
$7.46M 135,050 +135,050 New
KCM
56
Kennedy Capital Management
Missouri
$7.46M 134,890 -2,614 -2%
NL
57
Nuveen LLC
North Carolina
$7.16M 129,511 -23,260 -15%
SBH
58
Segall Bryant & Hamill
Illinois
$6.64M 120,159 +120,159 New
TD Asset Management
59
TD Asset Management
Ontario, Canada
$6.43M 116,332 -53,600 -32%
CLGM
60
Capitolis Liquid Global Markets
New York
$6.42M 116,100 +116,100 New
First Trust Advisors
61
First Trust Advisors
Illinois
$6.3M 113,907 +32,221 +39%
Deutsche Bank
62
Deutsche Bank
Germany
$6.14M 111,164 +45,469 +69%
OM
63
Opaleye Management
Massachusetts
$5.8M 105,000 – –
Manulife (Manufacturers Life Insurance)
64
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$5.24M 94,801 -26,049 -22%
Swiss National Bank
65
Swiss National Bank
Switzerland
$5.18M 93,800 +6,900 +8%
Neuberger Berman Group
66
Neuberger Berman Group
New York
$5.17M 93,582 +93,582 New
Assenagon Asset Management
67
Assenagon Asset Management
Luxembourg
$5.08M 91,875 +47,003 +105%
Victory Capital Management
68
Victory Capital Management
Texas
$5.03M 90,932 -11,479 -11%
Skandinaviska Enskilda Banken (SEB)
69
Skandinaviska Enskilda Banken (SEB)
Sweden
$4.57M 82,750 -166,200 -67%
Franklin Resources
70
Franklin Resources
California
$4.56M 82,579 +3,535 +4%
EAM
71
EFG Asset Management
Oregon
$4.52M 81,726 +10,592 +15%
CC
72
Checkpoint Capital
California
$4.49M 81,311 -93,873 -54%
Rafferty Asset Management
73
Rafferty Asset Management
New York
$4.45M 80,543 +36,286 +82%
DMKJ
74
David M. Knott Jr
$4.42M 80,000 +4,000 +5%
Northwestern Mutual Wealth Management
75
Northwestern Mutual Wealth Management
Wisconsin
$4.36M 78,894 – –
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