PTGX icon

Protagonist Therapeutics
PTGX

Overview Fund Activity

270 hedge funds and large institutions have $3.92B invested in Protagonist Therapeutics in 2025 Q2 according to their latest regulatory filings, with 50 funds opening new positions, 119 increasing their positions, 76 reducing their positions, and 49 closing their positions.

Holders
270
Holders Change
-4
Holders Change %
-1.46%
% of All Funds
3.63%
Holding in Top 10
14
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.19%
New
50
Increased
119
Reduced
76
Closed
49
Calls
$11.6M
Puts
$15.9M
Net Calls
-$4.31M
Net Calls Change
-$23.5M

Top Buyers

1
UBS Group
1
UBS Group
Switzerland
$138M
2
CC
2
Commodore Capital
New York
$59.4M
3
Adage Capital Partners
3
Adage Capital Partners
Massachusetts
$60.4M
4
BI
4
BVF Inc
California
$177M
5
Holocene Advisors
5
Holocene Advisors
New York
$29.3M

Top Sellers

1
T. Rowe Price Associates
1
T. Rowe Price Associates
Maryland
$51.8M
2
Focus Partners Wealth
2
Focus Partners Wealth
Massachusetts
$0
3
NVCHI
3
New Vernon Capital Holdings II
New Jersey
$398K
4
AGP
4
Artia Global Partners
Florida
$1.27M
5
Qube Research & Technologies (QRT)
5
Qube Research & Technologies (QRT)
United Kingdom
$3.81M
Name Market Value Shares Shares
Change 		Shares
Change %
Invesco
26
Invesco
Georgia
$39.9M 721,680 -137,968 -16%
Northern Trust
27
Northern Trust
Illinois
$34M 615,066 -24,441 -4%
Charles Schwab
28
Charles Schwab
California
$31.8M 575,364 +17,646 +3%
Fidelity Investments
29
Fidelity Investments
Massachusetts
$29.8M 538,432 +60,089 +13%
Holocene Advisors
30
Holocene Advisors
New York
$29.3M 530,326 +530,326 New
Janus Henderson Group
31
Janus Henderson Group
United Kingdom
$24.7M 446,828 +425,374 +1,983%
BNP Paribas Asset Management
32
BNP Paribas Asset Management
France
$24.7M 446,026 +66,377 +17%
JPMorgan Chase & Co
33
JPMorgan Chase & Co
New York
$24.6M 445,692 -23,207 -5%
Toronto Dominion Bank
34
Toronto Dominion Bank
Ontario, Canada
$24.6M 445,440 – –
6CM
35
683 Capital Management
New York
$24.6M 445,000 -55,000 -11%
AAA
36
Affinity Asset Advisors
New York
$24.3M 440,000 +40,000 +10%
JAM
37
Jupiter Asset Management
United Kingdom
$22.4M 405,644 +237,581 +141%
MP
38
Mangrove Partners
Connecticut
$21.9M 395,383 – –
Bank of New York Mellon
39
Bank of New York Mellon
New York
$21.4M 388,082 +11,219 +3%
Principal Financial Group
40
Principal Financial Group
Iowa
$18.2M 330,134 -16,961 -5%
Raymond James Financial
41
Raymond James Financial
Florida
$17.2M 311,986 +13,159 +4%
VOYA Investment Management
42
VOYA Investment Management
Georgia
$15.5M 280,354 +220,676 +370%
EP
43
Eversept Partners
New York
$15.3M 277,316 -269,800 -49%
UBS AM
44
UBS AM
Illinois
$13.5M 243,373 +34,617 +17%
Barclays
45
Barclays
United Kingdom
$11.7M 212,112 +100,680 +90%
Public Sector Pension Investment Board (PSP Investments)
46
Public Sector Pension Investment Board (PSP Investments)
Quebec, Canada
$11.7M 211,281 +22,250 +12%
Dimensional Fund Advisors
47
Dimensional Fund Advisors
Texas
$9.95M 180,050 +58,496 +48%
Renaissance Technologies
48
Renaissance Technologies
New York
$9.57M 173,134 -150,433 -46%
RhumbLine Advisers
49
RhumbLine Advisers
Massachusetts
$9.56M 173,028 +10,963 +7%
MAP
50
Moody Aldrich Partners
Massachusetts
$9.43M 170,570 +7,087 +4%
1
2
3 4 5