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Protagonist Therapeutics

312 hedge funds and large institutions have $6.18B invested in Protagonist Therapeutics in 2025 Q4 according to their latest regulatory filings, with 81 funds opening new positions, 97 increasing their positions, 103 reducing their positions, and 39 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more capital invested

Capital invested by funds: $ → $

more funds holding in top 10

Funds holding in top 10:

14% more funds holding

Funds holding: 274312 (+38)

0.49% less ownership

Funds ownership: 113.62%113.13% (-0.49%)

6% less repeat investments, than reductions

Existing positions increased: 97 | Existing positions reduced: 103

Holders
312
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
13
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$85.2M
Puts
$4.57M
Net Calls
Net Calls Change

Top Buyers

1 +$127M
2 +$103M
3 +$94.7M
4
Citadel Advisors
Citadel Advisors
Florida
+$72.7M
5
UBS Group
UBS Group
Switzerland
+$71.5M

Top Sellers

1 -$170M
2 -$114M
3 -$66.8M
4
RI
RTW Investments
New York
-$57.1M
5
CC
Commodore Capital
New York
-$47.1M
Name Holding Trade Value Shares
Change
Change in
Stake
JGC
101
J. Goldman & Co
New York
$4.05M
SC
102
SummitTX Capital
Texas
$3.69M
Creative Planning
103
Creative Planning
Kansas
$3.6M
Thrivent Financial for Lutherans
104
Thrivent Financial for Lutherans
Minnesota
$3.53M
LP
105
LMR Partners
United Kingdom
$3.49M
SOADOR
106
State of Alaska Department of Revenue
Alaska
$3.33M
EC
107
Elmind Capital
New York
$3.32M
SEI Investments
108
SEI Investments
Pennsylvania
$3.26M
ACM
109
Aquatic Capital Management
Illinois
$3.2M
ETC
110
Exchange Traded Concepts
Oklahoma
$3.06M
State of Wisconsin Investment Board
111
State of Wisconsin Investment Board
Wisconsin
$3.04M
Jane Street
112
Jane Street
New York
$3M
MIM
113
MetLife Investment Management
New Jersey
$2.83M
IMRF
114
Illinois Municipal Retirement Fund
Illinois
$2.73M
GC
115
Guggenheim Capital
Illinois
$2.72M
Mirae Asset Global ETFs Holdings
116
Mirae Asset Global ETFs Holdings
Hong Kong
$2.69M
LSERS
117
Louisiana State Employees Retirement System
Louisiana
$2.35M
Verition Fund Management
118
Verition Fund Management
Connecticut
$2.34M
TRSOTSOK
119
Teachers Retirement System of the State of Kentucky
Kentucky
$2.32M
KI
120
Keystone Investors
Singapore
$2.3M
PHP
121
Parkman Healthcare Partners
Connecticut
$2.27M
PA
122
Profund Advisors
Maryland
$2.23M
VRS
123
Virginia Retirement Systems
Virginia
$2.22M
AGP
124
Artia Global Partners
Florida
$2M
DP
125
Diadema Partners
New Jersey
$1.98M