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Protagonist Therapeutics

312 hedge funds and large institutions have $6.18B invested in Protagonist Therapeutics in 2025 Q4 according to their latest regulatory filings, with 81 funds opening new positions, 97 increasing their positions, 103 reducing their positions, and 39 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more capital invested

Capital invested by funds: $ → $

more funds holding in top 10

Funds holding in top 10:

14% more funds holding

Funds holding: 274312 (+38)

0.49% less ownership

Funds ownership: 113.62%113.13% (-0.49%)

6% less repeat investments, than reductions

Existing positions increased: 97 | Existing positions reduced: 103

Holders
312
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
13
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$85.2M
Puts
$4.57M
Net Calls
Net Calls Change

Top Buyers

1 +$127M
2 +$103M
3 +$94.7M
4
Citadel Advisors
Citadel Advisors
Florida
+$72.7M
5
UBS Group
UBS Group
Switzerland
+$71.5M

Top Sellers

1 -$170M
2 -$114M
3 -$66.8M
4
RI
RTW Investments
New York
-$57.1M
5
CC
Commodore Capital
New York
-$47.1M
Name Holding Trade Value Shares
Change
Change in
Stake
ASRS
151
Arizona State Retirement System
Arizona
$1.22M
CUAMC
152
China Universal Asset Management Company
China
$1.2M
EAM
153
Erste Asset Management
Austria
$1.19M
OPERF
154
Oregon Public Employees Retirement Fund
Oregon
$1.17M
Connor, Clark & Lunn Investment Management (CC&L)
155
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
$1.16M
Comerica Bank
156
Comerica Bank
Texas
$1.14M
Allianz Asset Management
157
Allianz Asset Management
Germany
$1.14M
JG
158
Jain Global
New York
$1.12M
GT
159
Glenmede Trust
Pennsylvania
$1.11M
HSA
160
Hussman Strategic Advisors
Maryland
$1.1M
Susquehanna International Group
161
Susquehanna International Group
Pennsylvania
$1.03M
WG
162
Winton Group
United Kingdom
$1M
FSA
163
Franklin Street Advisors
North Carolina
$987K
KK
164
KLP Kapitalforvaltning
Norway
$926K
CA
165
Cache Advisors
California
$886K
Zurich Cantonal Bank
166
Zurich Cantonal Bank
Switzerland
$880K
DACS
167
Dymon Asia Capital (Singapore)
Singapore
$873K
Cerity Partners
168
Cerity Partners
New York
$790K
FC
169
FORA Capital
Florida
$788K
MSRPS
170
Maryland State Retirement & Pension System
Maryland
$751K
AA
171
AlphaCentric Advisors
Puerto Rico
$747K
BAMCO Inc
172
BAMCO Inc
New York
$725K
Renaissance Technologies
173
Renaissance Technologies
New York
$713K
SFCML
174
Seven Fleet Capital Management LP
California
$699K
PAP
175
Persistent Asset Partners
Hong Kong
$691K