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Protagonist Therapeutics

312 hedge funds and large institutions have $6.18B invested in Protagonist Therapeutics in 2025 Q4 according to their latest regulatory filings, with 81 funds opening new positions, 97 increasing their positions, 103 reducing their positions, and 39 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more capital invested

Capital invested by funds: $ → $

more funds holding in top 10

Funds holding in top 10:

14% more funds holding

Funds holding: 274312 (+38)

0.49% less ownership

Funds ownership: 113.62%113.13% (-0.49%)

6% less repeat investments, than reductions

Existing positions increased: 97 | Existing positions reduced: 103

Holders
312
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
13
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$85.2M
Puts
$4.57M
Net Calls
Net Calls Change

Top Buyers

1 +$127M
2 +$103M
3 +$94.7M
4
Citadel Advisors
Citadel Advisors
Florida
+$72.7M
5
UBS Group
UBS Group
Switzerland
+$71.5M

Top Sellers

1 -$170M
2 -$114M
3 -$66.8M
4
RI
RTW Investments
New York
-$57.1M
5
CC
Commodore Capital
New York
-$47.1M
Name Holding Trade Value Shares
Change
Change in
Stake
DB
276
Danske Bank
Denmark
$8.73K
MCM
277
MAI Capital Management
Ohio
$8.47K
WA
278
WPG Advisers
Maryland
$8.38K
RIL
279
Rothschild Investment LLC
Illinois
$7.51K
PFBT
280
Parkside Financial Bank & Trust
Missouri
$7.34K
BBHC
281
Brown Brothers Harriman & Co
New York
$7.08K
BIA
282
Bell Investment Advisors
California
$7.08K
AGWCA
283
Annis Gardner Whiting Capital Advisors
Florida
$6.64K
SS
284
SBI Securities
Japan
$6.11K
SGL
285
Sankala Group LLC
Colorado
$5.53K
Jones Financial Companies
286
Jones Financial Companies
Missouri
$4.02K
TM
287
Torren Management
California
$3.41K
HNB
288
Huntington National Bank
Ohio
$3.06K
WWM
289
Wolff Wiese Magana
California
$3.06K
FMII
290
Farmers & Merchants Investments Inc
Nebraska
$3.06K
MAM
291
Marquette Asset Management
Minnesota
$2.45K
VCM
292
Versant Capital Management
Arizona
$2.36K
PMAM
293
Picton Mahoney Asset Management
Ontario, Canada
$2.18K
EW
294
Elyxium Wealth
California
$1.92K
PWA
295
Physician Wealth Advisors
Utah
$1.83K
OP
296
ORG Partners
Indiana
$1.66K
TCM
297
Triumph Capital Management
Colorado
$1.57K
CIBC Private Wealth Group
298
CIBC Private Wealth Group
Georgia
$1.14K
AW
299
Ankerstar Wealth
Texas
$1.05K
AAP
300
Arax Advisory Partners
Colorado
$874