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Protagonist Therapeutics

312 hedge funds and large institutions have $6.18B invested in Protagonist Therapeutics in 2025 Q4 according to their latest regulatory filings, with 81 funds opening new positions, 97 increasing their positions, 103 reducing their positions, and 39 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more capital invested

Capital invested by funds: $ → $

more funds holding in top 10

Funds holding in top 10:

14% more funds holding

Funds holding: 274312 (+38)

0.49% less ownership

Funds ownership: 113.62%113.13% (-0.49%)

6% less repeat investments, than reductions

Existing positions increased: 97 | Existing positions reduced: 103

Holders
312
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
13
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$85.2M
Puts
$4.57M
Net Calls
Net Calls Change

Top Buyers

1 +$127M
2 +$103M
3 +$94.7M
4
Citadel Advisors
Citadel Advisors
Florida
+$72.7M
5
UBS Group
UBS Group
Switzerland
+$71.5M

Top Sellers

1 -$170M
2 -$114M
3 -$66.8M
4
RI
RTW Investments
New York
-$57.1M
5
CC
Commodore Capital
New York
-$47.1M
Name Holding Trade Value Shares
Change
Change in
Stake
TC
301
Trust Company
Kansas
$611
FHA
302
Flagship Harbor Advisors
Massachusetts
$524
GWM
303
Gilpin Wealth Management
Colorado
$437
AWM
304
Abound Wealth Management
Tennessee
$350
DF
305
DecisionPoint Financial
Arizona
$350
KG
306
Kilter Group
New York
$350
TCM
307
TD Capital Management
Tennessee
$349
RFP
308
Root Financial Partners
California
$262
HI
309
Harbour Investments
Wisconsin
$175
HFS
310
Hughes Financial Services
Virginia
$175
KFAS
311
Keating Financial Advisory Services
Kansas
$175
BI
312
BVF Inc
California
DTC
313
Deep Track Capital
Connecticut
LCM
314
Lynx1 Capital Management
Puerto Rico
MP
315
Mangrove Partners
Connecticut
Focus Partners Wealth
316
Focus Partners Wealth
Massachusetts
Toronto Dominion Bank
317
Toronto Dominion Bank
Ontario, Canada
LGM
318
Logos Global Management
California
ECM
319
ExodusPoint Capital Management
New York
SSA
320
Schonfeld Strategic Advisors
New York
Assenagon Asset Management
321
Assenagon Asset Management
Luxembourg
AA
322
ALPS Advisors
Colorado
SCM
323
Superstring Capital Management
New York
Capital Fund Management (CFM)
324
Capital Fund Management (CFM)
France
MWM
325
Moran Wealth Management
Florida