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Protagonist Therapeutics
PTGX

Overview Fund Activity

271 hedge funds and large institutions have $3.92B invested in Protagonist Therapeutics in 2025 Q2 according to their latest regulatory filings, with 50 funds opening new positions, 119 increasing their positions, 77 reducing their positions, and 49 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
271
Holders Change
-3
Holders Change %
-1.09%
% of All Funds
3.63%
Holding in Top 10
14
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.19%
New
50
Increased
119
Reduced
77
Closed
49
Calls
$18.4M
Puts
$20.8M
Net Calls
-$2.39M
Net Calls Change
-$21.6M

Top Buyers

1
UBS Group
UBS Group
Switzerland
$138M
2
CC
Commodore Capital
New York
$59.4M
3
Adage Capital Partners
Adage Capital Partners
Massachusetts
$60.4M
4
BI
BVF Inc
California
$177M
5
Holocene Advisors
Holocene Advisors
New York
$29.3M

Top Sellers

1
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
$51.8M
2
Focus Partners Wealth
Focus Partners Wealth
Massachusetts
$0
3
NVCHI
New Vernon Capital Holdings II
New Jersey
$398K
4
AGP
Artia Global Partners
Florida
$1.27M
5
Qube Research & Technologies (QRT)
Qube Research & Technologies (QRT)
United Kingdom
$3.81M
Name Holding Trade Value Shares
Change 		Shares
Change %
OQS
301
Occudo Quantitative Strategies
Florida
– -$405K -8,281 Closed
LCM
302
Landscape Capital Management
New Jersey
– -$375K -7,758 Closed
CM
303
Capula Management
Cayman Islands
– -$372K -7,684 Closed
FAM
304
Fred Alger Management
New York
– -$362K -7,477 Closed
SC
305
SummitTX Capital
Texas
– -$285K -5,900 Closed
Two Sigma Investments
306
Two Sigma Investments
New York
– -$278K -5,741 Closed
VF
307
Virtu Financial
New York
– -$200K -4,140 Closed
QCG
308
Quadrant Capital Group
Ohio
– -$159K -3,278 Closed
Acadian Asset Management
309
Acadian Asset Management
Massachusetts
– -$146K -3,026 Closed
A
310
AlphaQuest
New York
– -$131K -2,704 Closed
PCM
311
Penserra Capital Management
California
– -$117K -2,429 Closed
Amundi
312
Amundi
France
– -$95.7K -2,058 Closed
ACM
313
Aster Capital Management
United Arab Emirates
– -$60.8K -1,617 Closed
Macquarie Group
314
Macquarie Group
Australia
– -$13.7K -283 Closed
SW
315
SVB Wealth
Massachusetts
– -$12.6K -261 Closed
CCM
316
Coldstream Capital Management
Washington
– -$4.79K -99 Closed
CA
317
CoreCap Advisors
Michigan
– -$3.43K -71 Closed
CFD
318
Creative Financial Designs
Indiana
– -$967 -20 Closed
SC
319
Stephens Consulting
Michigan
– -$968 -20 Closed
Optiver Holding
320
Optiver Holding
Netherlands
– -$532 -11 Closed
TFM
321
TFC Financial Management
Massachusetts
– -$49 -1 Closed
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