Jane Street
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Jane Street’s Protagonist Therapeutics PTGX Stock Holding History

Jane Street’s Portfolio PTGX Stock Details PTGX Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$380K Sell
3,607
-30,700
-89% -$2.72M ﹤0.01% 8675
2025
Q4 		$3M Sell
34,307
-10,032
-23% -$821K ﹤0.01% 4039
2025
Q3 		$2.95M Buy
+44,339
New +$2.52M ﹤0.01% 4259
2025
Q2 		– Sell
-193,300
Closed -$9.28M – 10619
2025
Q1 		$9.35M Buy
193,300
+131,749
+214% +$5.52M ﹤0.01% 2080
2024
Q4 		$2.38M Buy
61,551
+28,693
+87% +$1.25M ﹤0.01% 3815
2024
Q3 		$1.48M Sell
32,858
-136,453
-81% -$5.51M ﹤0.01% 5073
2024
Q2 		$5.87M Buy
169,311
+88,041
+108% +$2.58M ﹤0.01% 2728
2024
Q1 		$2.35M Buy
81,270
+8,339
+11% +$227K ﹤0.01% 3840
2023
Q4 		$1.67M Buy
72,931
+34,425
+89% +$602K ﹤0.01% 4650
2023
Q3 		$642K Buy
38,506
+16,697
+77% +$324K ﹤0.01% 5876
2023
Q2 		$602K Sell
21,809
-34,407
-61% -$861K ﹤0.01% 6038
2023
Q1 		$1.29M Buy
56,216
+325
+0.6% +$5.46K ﹤0.01% 4546
2022
Q4 		$610K Buy
55,891
+45,602
+443% +$385K ﹤0.01% 5789
2022
Q3 		$87K Sell
10,289
-27,667
-73% -$262K ﹤0.01% 8722
2022
Q2 		$300K Buy
+37,956
New +$459K ﹤0.01% 7608
2022
Q1 		– Sell
-76,396
Closed -$2.15M – 10885
2021
Q4 		$2.61M Buy
76,396
+18,542
+32% +$586K ﹤0.01% 3949
2021
Q3 		$1.02M Buy
+57,854
New +$2.47M ﹤0.01% 5855
2021
Q1 		– Sell
-14,473
Closed -$292K – 9487
2020
Q4 		$292K Buy
14,473
+1,205
+9% +$25.9K ﹤0.01% 6458
2020
Q3 		$259K Buy
+13,268
New +$249K ﹤0.01% 6094
2018
Q3 		– Sell
-12,945
Closed -$87K – 5588
2018
Q2 		$87K Buy
+12,945
New +$99.4K ﹤0.01% 4761
2016
Q4 		– Sell
-10,964
Closed -$232K – 4497
2016
Q3 		$232K Buy
+10,964
New +$150K ﹤0.01% 3557

Other funds holding PTGX

BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
FCM
Farallon Capital Management San Francisco, California $17.5B AUM 50.95% 1-Year Est. Return
UBS Group
UBS Group Zurich, Switzerland $666B AUM 30.12% 1-Year Est. Return
RI
RTW Investments New York $10B AUM 135.35% 1-Year Est. Return
Wellington Management Group
Wellington Management Group Boston, Massachusetts $535B AUM 26.23% 1-Year Est. Return
VPM
Vanguard Portfolio Management Malvern, Pennsylvania $1.91T AUM
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return
Janus Henderson Group
Janus Henderson Group London, United Kingdom $209B AUM 37.72% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
JJ
Johnson & Johnson New Brunswick, New Jersey $652M AUM 198.07% 1-Year Est. Return

Jane Street's PTGX Position: Q1 2026 in Review

Jane Street reduced its Protagonist Therapeutics (PTGX) stake by 89% in Q1 2026, selling an estimated $2.72M and leaving 3,607 shares worth $380K. The position accounts for ﹤0.01% of the portfolio, ranked #8675.

Jane Street first reported a position in PTGX in Q3 2016 and has held it in 21 quarters since. The position peaked at $9.35M in Q1 2025. 317 funds tracked by Wall St. Rank hold PTGX as of Q1 2026.

  • Jane Street held 3,607 shares of Protagonist Therapeutics worth $380K as of Q1 2026.
  • Jane Street sold 30,700 Protagonist Therapeutics shares in Q1 2026, an estimated $2.72M.
  • Protagonist Therapeutics made up ﹤0.01% of Jane Street's portfolio in Q1 2026, its #8675 holding.
  • Jane Street first reported a position in Protagonist Therapeutics in Q3 2016 and has held it in 21 quarters since.
  • Jane Street's Protagonist Therapeutics position peaked at $9.35M in Q1 2025.
  • 317 funds tracked by Wall St. Rank held Protagonist Therapeutics as of Q1 2026.

Based on Jane Street's 13F filing for Q1 2026, filed 12 May 2026.