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Prime Medicine

192 hedge funds and large institutions have $343M invested in Prime Medicine in 2026 Q1 according to their latest regulatory filings, with 39 funds opening new positions, 73 increasing their positions, 50 reducing their positions, and 25 closing their positions.

New
Increased
Maintained
Reduced
Closed

56% more first-time investments, than exits

New positions opened: 39 | Existing positions closed: 25

46% more repeat investments, than reductions

Existing positions increased: 73 | Existing positions reduced: 50

27% more call options, than puts

Call options by funds: $3.62M | Put options by funds: $2.86M

5% more funds holding

Funds holding: 183192 (+9)

2% more capital invested

Capital invested by funds: $337M → $343M (+$5.94M)

0.84% more ownership

Funds ownership: 53.75%54.59% (+0.84%)

100% less funds holding in top 10

Funds holding in top 10: 10 (-1)

Holders
192
Holders Change
+9
Holders Change %
+4.92%
% of All Funds
2.36%
Holding in Top 10
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-100%
% of All Funds
New
39
Increased
73
Reduced
50
Closed
25
Calls
$3.62M
Puts
$2.86M
Net Calls
+$760K
Net Calls Change
+$1.05M
Name Holding Trade Value Shares
Change
Change in
Stake
Renaissance Technologies
26
Renaissance Technologies
New York
$2.58M -$1.55M -408,120 -36%
VFT
27
Vanguard Fiduciary Trust
Pennsylvania
$2.5M +$2.73M +717,002 New
Susquehanna International Group
28
Susquehanna International Group
Pennsylvania
$2.49M -$1.75M -460,898 -39%
Morgan Stanley
29
Morgan Stanley
New York
$2.23M -$2.02M -530,441 -45%
HF
30
HRT Financial
New York
$2.13M -$162K -42,582 -6%
Bank of America
31
Bank of America
North Carolina
$2.01M -$270K -71,008 -11%
AQR Capital Management
32
AQR Capital Management
Connecticut
$1.93M +$529K +139,114 +33%
MCM
33
Moore Capital Management
New York
$1.74M
CCC
34
Chelsea Counsel Company
California
$1.61M +$896K +235,340 +104%
ACM
35
Alessandra Capital Management
California
$1.48M +$1.62M +425,510 New
BG
36
Bollard Group
Massachusetts
$1.26M
HighTower Advisors
37
HighTower Advisors
Illinois
$1.18M -$228K -59,855 -15%
Citadel Advisors
38
Citadel Advisors
Florida
$1.17M +$851K +223,488 +198%
Wells Fargo
39
Wells Fargo
California
$1.11M +$95.4K +25,054 +9%
Dimensional Fund Advisors
40
Dimensional Fund Advisors
Texas
$1.06M +$839K +220,468 +262%
Wellington Management Group
41
Wellington Management Group
Massachusetts
$968K +$114K +29,893 +12%
N
42
Nuveen
North Carolina
$960K +$92.5K +24,295 +10%
Bank of New York Mellon
43
Bank of New York Mellon
New York
$930K +$77.8K +20,449 +8%
Rafferty Asset Management
44
Rafferty Asset Management
New York
$750K +$106K +27,871 +15%
IEFM
45
IQ EQ Fund Management
Ireland
$715K +$102K +26,870 +15%
GAA
46
Green Alpha Advisors
Colorado
$665K +$1.1K +288 +0.2%
Swiss National Bank
47
Swiss National Bank
Switzerland
$622K +$32.4K +8,500 +5%
KFGK
48
Keystone Financial Group (Kentucky)
Kentucky
$578K +$138K +36,345 +28%
Deutsche Bank
49
Deutsche Bank
Germany
$548K +$36.1K +9,497 +6%
XT
50
XTX Topco
Cayman Islands
$547K +$321K +84,347 +116%