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Prime Medicine
PRME

Overview Fund Activity

120 hedge funds and large institutions have $145M invested in Prime Medicine in 2025 Q2 according to their latest regulatory filings, with 29 funds opening new positions, 37 increasing their positions, 34 reducing their positions, and 32 closing their positions.

Holders
120
Holders Change
-3
Holders Change %
-2.44%
% of All Funds
1.61%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.01%
New
29
Increased
37
Reduced
34
Closed
32
Calls
$1.42M
Puts
$1.22M
Net Calls
+$203K
Net Calls Change
+$320K

Top Buyers

1
T. Rowe Price Investment Management
1
T. Rowe Price Investment Management
Maryland
$16M
2
CC
2
Casdin Capital
New York
$3.87M
3
SSA
3
Schonfeld Strategic Advisors
New York
$2.02M
4
Citadel Advisors
4
Citadel Advisors
Florida
$1.29M
5
FAM
5
Fred Alger Management
New York
$946K

Top Sellers

1
Millennium Management
1
Millennium Management
New York
$366K
2
T. Rowe Price Associates
2
T. Rowe Price Associates
Maryland
$162K
3
Sumitomo Mitsui Trust Group
3
Sumitomo Mitsui Trust Group
Japan
$3.94M
4
NAMA
4
Nikko Asset Management Americas
New York
$3.89M
5
BBA
5
Baker Bros. Advisors
New York
$0
Name Holding Trade Value Shares
Change 		Shares
Change %
Two Sigma Investments
26
Two Sigma Investments
New York
$638K -$857 -347 -0.1%
Renaissance Technologies
27
Renaissance Technologies
New York
$552K -$554K -224,200 -50%
BCM
28
Bridgeway Capital Management
Texas
$531K +$531K +214,800 New
CCC
29
Chelsea Counsel Company
California
$514K – – –
NL
30
Nuveen LLC
North Carolina
$513K +$367K +148,492 +250%
Goldman Sachs
31
Goldman Sachs
New York
$511K -$110K -44,391 -18%
UBS Group
32
UBS Group
Switzerland
$482K +$192K +77,647 +66%
Simplex Trading
33
Simplex Trading
Illinois
$478K +$457K +185,239 +2,212%
PWM
34
Palumbo Wealth Management
New York
$453K +$217K +87,896 +92%
AllianceBernstein
35
AllianceBernstein
Tennessee
$414K +$226K +91,420 +120%
Bank of New York Mellon
36
Bank of New York Mellon
New York
$400K +$15K +6,060 +4%
Millennium Management
37
Millennium Management
New York
$366K -$4.03M -1,631,949 -92%
Bank of America
38
Bank of America
North Carolina
$357K +$78K +31,585 +28%
LCS
39
Levin Capital Strategies
New York
$346K +$259K +105,000 +300%
XT
40
XTX Topco
Cayman Islands
$330K +$330K +133,490 New
Deutsche Bank
41
Deutsche Bank
Germany
$310K -$3.46K -1,401 -1%
Mirae Asset Global ETFs Holdings
42
Mirae Asset Global ETFs Holdings
Hong Kong
$296K +$212K +85,938 +253%
Fidelity International
43
Fidelity International
Bermuda
$290K -$9.26K -3,747 -3%
Barclays
44
Barclays
United Kingdom
$284K +$107K +43,378 +61%
DC
45
Diametric Capital
Massachusetts
$261K +$261K +105,530 New
Wells Fargo
46
Wells Fargo
California
$250K +$25.5K +10,332 +11%
National Bank of Canada
47
National Bank of Canada
Quebec, Canada
$244K +$244K +98,807 New
RhumbLine Advisers
48
RhumbLine Advisers
Massachusetts
$242K +$39.7K +16,072 +20%
GAA
49
Green Alpha Advisors
Colorado
$195K -$11K -4,473 -5%
MA
50
Mutual Advisors
Nebraska
$190K +$190K +45,200 New
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