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Prime Medicine
PRME

Overview Fund Activity

120 hedge funds and large institutions have $145M invested in Prime Medicine in 2025 Q2 according to their latest regulatory filings, with 29 funds opening new positions, 37 increasing their positions, 34 reducing their positions, and 32 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
120
Holders Change
-3
Holders Change %
-2.44%
% of All Funds
1.61%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.01%
New
29
Increased
37
Reduced
34
Closed
32
Calls
$1.42M
Puts
$1.22M
Net Calls
+$203K
Net Calls Change
+$320K

Top Buyers

1
T. Rowe Price Investment Management
T. Rowe Price Investment Management
Maryland
$16M
2
CC
Casdin Capital
New York
$3.87M
3
SSA
Schonfeld Strategic Advisors
New York
$2.02M
4
Citadel Advisors
Citadel Advisors
Florida
$1.29M
5
FAM
Fred Alger Management
New York
$946K

Top Sellers

1
Millennium Management
Millennium Management
New York
$366K
2
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
$162K
3
Sumitomo Mitsui Trust Group
Sumitomo Mitsui Trust Group
Japan
$3.94M
4
NAMA
Nikko Asset Management Americas
New York
$3.89M
5
BBA
Baker Bros. Advisors
New York
$0
Name Holding Trade Value Shares
Change 		Shares
Change %
AI
1
Alphabet Inc
California
$37.2M – – –
T. Rowe Price Investment Management
2
T. Rowe Price Investment Management
Maryland
$16M +$5.78M +2,341,691 +57%
BlackRock
3
BlackRock
New York
$11.1M +$444K +179,617 +4%
Fidelity Investments
4
Fidelity Investments
Massachusetts
$9.25M -$6.94K -2,808 -0.1%
Vanguard Group
5
Vanguard Group
Pennsylvania
$8.96M -$34.2K -13,838 -0.4%
AIM
6
ARK Investment Management
Florida
$5.74M -$1.91M -772,503 -25%
RG
7
Redmile Group
California
$5.12M – – –
MM
8
MWG Management
British Virgin Islands
$4.43M – – –
Sumitomo Mitsui Trust Group
9
Sumitomo Mitsui Trust Group
Japan
$3.94M -$3.29M -1,331,505 -46%
NAMA
10
Nikko Asset Management Americas
New York
$3.89M -$3.28M -1,336,906 -46%
CC
11
Casdin Capital
New York
$3.87M +$2.96M +1,200,000 +327%
Geode Capital Management
12
Geode Capital Management
Massachusetts
$3.73M -$39K -15,781 -1%
State Street
13
State Street
Massachusetts
$3.06M +$232K +94,032 +8%
GWM
14
Greenwich Wealth Management
Connecticut
$2.09M +$67.2K +27,200 +3%
SSA
15
Schonfeld Strategic Advisors
New York
$2.02M +$2.02M +818,518 New
FCM
16
Farallon Capital Management
California
$1.85M – – –
Morgan Stanley
17
Morgan Stanley
New York
$1.45M +$574K +232,500 +65%
Citadel Advisors
18
Citadel Advisors
Florida
$1.29M +$1.29M +521,508 New
Charles Schwab
19
Charles Schwab
California
$1.28M +$36.9K +14,931 +3%
Northern Trust
20
Northern Trust
Illinois
$1.27M -$37.2K -15,075 -3%
MCM
21
Moore Capital Management
New York
$1.24M – – –
Susquehanna International Group
22
Susquehanna International Group
Pennsylvania
$1.19M +$840K +340,109 +238%
AQR Capital Management
23
AQR Capital Management
Connecticut
$1.05M +$446K +180,560 +74%
FAM
24
Fred Alger Management
New York
$946K +$946K +383,194 New
BG
25
Bollard Group
Massachusetts
$892K – – –
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