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Prime Medicine

192 hedge funds and large institutions have $343M invested in Prime Medicine in 2026 Q1 according to their latest regulatory filings, with 39 funds opening new positions, 73 increasing their positions, 50 reducing their positions, and 25 closing their positions.

New
Increased
Maintained
Reduced
Closed

56% more first-time investments, than exits

New positions opened: 39 | Existing positions closed: 25

46% more repeat investments, than reductions

Existing positions increased: 73 | Existing positions reduced: 50

27% more call options, than puts

Call options by funds: $3.62M | Put options by funds: $2.86M

5% more funds holding

Funds holding: 183192 (+9)

2% more capital invested

Capital invested by funds: $337M → $343M (+$5.94M)

0.84% more ownership

Funds ownership: 53.75%54.59% (+0.84%)

100% less funds holding in top 10

Funds holding in top 10: 10 (-1)

Holders
192
Holders Change
+9
Holders Change %
+4.92%
% of All Funds
2.36%
Holding in Top 10
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-100%
% of All Funds
New
39
Increased
73
Reduced
50
Closed
25
Calls
$3.62M
Puts
$2.86M
Net Calls
+$760K
Net Calls Change
+$1.05M
Name Holding Trade Value Shares
Change
Change in
Stake
AI
1
Alphabet Inc
California
$57.6M
BlackRock
2
BlackRock
New York
$29.6M +$886K +232,865 +3%
State Street
3
State Street
Massachusetts
$22.1M +$4.76M +1,249,615 +25%
AIM
4
ARK Investment Management
Florida
$21.7M +$3.34M +878,301 +16%
T. Rowe Price Investment Management
5
T. Rowe Price Investment Management
Maryland
$19.1M -$1.95M -513,290 -9%
VCM
6
Vanguard Capital Management
Pennsylvania
$15.6M +$17M +4,474,162 New
Balyasny Asset Management
7
Balyasny Asset Management
Illinois
$14.3M +$3.8M +999,003 +32%
CC
8
Casdin Capital
New York
$11M
WP
9
Woodline Partners
California
$10.5M +$1.78K +469 +0%
Sumitomo Mitsui Trust Group
10
Sumitomo Mitsui Trust Group
Japan
$10.2M -$1.16M -304,713 -9%
NAMA
11
Nikko Asset Management Americas
New York
$10.2M -$1.16M -304,713 -9%
UBS Group
12
UBS Group
Switzerland
$10.1M +$1.7M +447,835 +18%
Geode Capital Management
13
Geode Capital Management
Massachusetts
$9.55M +$439K +115,271 +4%
ACM
14
ADAR1 Capital Management
Texas
$6.87M +$7.51M +1,973,282 New
Fidelity Investments
15
Fidelity Investments
Massachusetts
$6.16M -$1.55M -407,170 -19%
RG
16
Redmile Group
California
$5.54M +$6.05M +1,590,832 New
Two Sigma Investments
17
Two Sigma Investments
New York
$5.47M -$215K -56,513 -3%
D.E. Shaw & Co
18
D.E. Shaw & Co
New York
$4.85M -$600K -157,748 -10%
FCM
19
Farallon Capital Management
California
$4.32M
Goldman Sachs
20
Goldman Sachs
New York
$3.38M -$2.99M -785,343 -45%
Charles Schwab
21
Charles Schwab
California
$3.19M -$74.6K -19,603 -2%
Northern Trust
22
Northern Trust
Illinois
$3.09M +$170K +44,563 +5%
VPM
23
Vanguard Portfolio Management
Pennsylvania
$3M +$3.28M +862,204 New
JP Morgan Chase
24
JP Morgan Chase
New York
$2.66M +$1.55M +408,444 +94%
GWM
25
Greenwich Wealth Management
Connecticut
$2.61M +$38.1K +10,000 +1%