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Prime Medicine
PRME

192 hedge funds and large institutions have $343M invested in Prime Medicine in 2026 Q1 according to their latest regulatory filings, with 39 funds opening new positions, 73 increasing their positions, 50 reducing their positions, and 25 closing their positions.

New
Increased
Maintained
Reduced
Closed

56% more first-time investments, than exits

New positions opened: 39 | Existing positions closed: 25

46% more repeat investments, than reductions

Existing positions increased: 73 | Existing positions reduced: 50

27% more call options, than puts

Call options by funds: $3.62M | Put options by funds: $2.86M

5% more funds holding

Funds holding: 183 → 192 (+9)

2% more capital invested

Capital invested by funds: $337M → $343M (+$5.94M)

0.84% more ownership

Funds ownership: 53.75% → 54.59% (+0.84%)

100% less funds holding in top 10

Funds holding in top 10: 1 → 0 (-1)

Holders
192
Holders Change
+9
Holders Change %
+4.92%
% of All Funds
2.36%
Holding in Top 10
–
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-100%
% of All Funds
–
New
39
Increased
73
Reduced
50
Closed
25
Calls
$3.62M
Puts
$2.86M
Net Calls
+$760K
Net Calls Change
+$1.05M

Top Buyers

1
ACM
ADAR1 Capital Management
Texas
+$7.51M
2
RG
Redmile Group
California
+$6.05M
3
State Street
State Street
Massachusetts
+$4.76M
4
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$3.8M
5
AIM
ARK Investment Management
Florida
+$3.34M

Top Sellers

1
Goldman Sachs
Goldman Sachs
New York
-$2.99M
2
Morgan Stanley
Morgan Stanley
New York
-$2.02M
3
T. Rowe Price Investment Management
T. Rowe Price Investment Management
Maryland
-$1.95M
4
Point72 Asset Management
Point72 Asset Management
Connecticut
-$1.91M
5
Susquehanna International Group
Susquehanna International Group
Pennsylvania
-$1.75M
Name Holding Trade Value Shares
Change 		Change in
Stake
AI
1
Alphabet Inc
California
$57.6M – – –
BlackRock
2
BlackRock
New York
$29.6M +$886K +232,865 +3%
State Street
3
State Street
Massachusetts
$22.1M +$4.76M +1,249,615 +25%
AIM
4
ARK Investment Management
Florida
$21.7M +$3.34M +878,301 +16%
T. Rowe Price Investment Management
5
T. Rowe Price Investment Management
Maryland
$19.1M -$1.95M -513,290 -9%
VCM
6
Vanguard Capital Management
Pennsylvania
$15.6M +$17M +4,474,162 New
Balyasny Asset Management
7
Balyasny Asset Management
Illinois
$14.3M +$3.8M +999,003 +32%
CC
8
Casdin Capital
New York
$11M – – –
WP
9
Woodline Partners
California
$10.5M +$1.78K +469 +0%
Sumitomo Mitsui Trust Group
10
Sumitomo Mitsui Trust Group
Japan
$10.2M -$1.16M -304,713 -9%
NAMA
11
Nikko Asset Management Americas
New York
$10.2M -$1.16M -304,713 -9%
UBS Group
12
UBS Group
Switzerland
$10.1M +$1.7M +447,835 +18%
Geode Capital Management
13
Geode Capital Management
Massachusetts
$9.55M +$439K +115,271 +4%
ACM
14
ADAR1 Capital Management
Texas
$6.87M +$7.51M +1,973,282 New
Fidelity Investments
15
Fidelity Investments
Massachusetts
$6.16M -$1.55M -407,170 -19%
RG
16
Redmile Group
California
$5.54M +$6.05M +1,590,832 New
Two Sigma Investments
17
Two Sigma Investments
New York
$5.47M -$215K -56,513 -3%
D.E. Shaw & Co
18
D.E. Shaw & Co
New York
$4.85M -$600K -157,748 -10%
FCM
19
Farallon Capital Management
California
$4.32M – – –
Goldman Sachs
20
Goldman Sachs
New York
$3.38M -$2.99M -785,343 -45%
Charles Schwab
21
Charles Schwab
California
$3.19M -$74.6K -19,603 -2%
Northern Trust
22
Northern Trust
Illinois
$3.09M +$170K +44,563 +5%
VPM
23
Vanguard Portfolio Management
Pennsylvania
$3M +$3.28M +862,204 New
JP Morgan Chase
24
JP Morgan Chase
New York
$2.66M +$1.55M +408,444 +94%
GWM
25
Greenwich Wealth Management
Connecticut
$2.61M +$38.1K +10,000 +1%
1
2 3 4 5

PRME Hedge Fund Activity: Q1 2026 in Review

192 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Prime Medicine (PRME) for Q1 2026, worth a combined $343M — up 1.8% from $337M a quarter earlier.

Buyers outnumbered sellers: 39 funds opened new PRME positions and 25 closed out — a net gain of 14 holders — while 73 added to existing stakes and 50 trimmed.

The largest buyer was ADAR1 Capital Management, opening a new position worth an estimated $7.51M. The largest seller was Goldman Sachs, cutting an estimated $2.99M.

  • 192 institutional investors held Prime Medicine (PRME) as of Q1 2026, up from 183 in Q4 2025.
  • Funds reported $343M of Prime Medicine stock for Q1 2026, up 1.8% quarter-over-quarter.
  • 39 funds opened new Prime Medicine positions in Q1 2026 and 25 closed out, a net change of +14 holders.
  • The largest Prime Medicine buyer in Q1 2026 was ADAR1 Capital Management, an estimated $7.51M added.
  • The largest Prime Medicine seller in Q1 2026 was Goldman Sachs, an estimated $2.99M sold.

Based on aggregated 13F filings for Q1 2026.