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Prime Medicine
PRME

125 hedge funds and large institutions have $120M invested in Prime Medicine in 2025 Q1 according to their latest regulatory filings, with 22 funds opening new positions, 41 increasing their positions, 36 reducing their positions, and 29 closing their positions.

New
Increased
Maintained
Reduced
Closed

14% more repeat investments, than reductions

Existing positions increased: 41 | Existing positions reduced: 36

0% more funds holding in top 10

Funds holding in top 10: 1 → 1 (0)

3.01% less ownership

Funds ownership: 49.05% → 46.04% (-3%)

5% less funds holding

Funds holding: 132 → 125 (-7)

24% less first-time investments, than exits

New positions opened: 22 | Existing positions closed: 29

36% less capital invested

Capital invested by funds: $188M → $120M (-$67.6M)

49% less call options, than puts

Call options by funds: $120K | Put options by funds: $237K

Holders
125
Holders Change
-7
Holders Change %
-5.3%
% of All Funds
1.68%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.01%
New
22
Increased
41
Reduced
36
Closed
29
Calls
$120K
Puts
$237K
Net Calls
-$117K
Net Calls Change
+$193K

Top Buyers

Rank Fund Capital Flow
1
Renaissance Technologies
Renaissance Technologies
New York
+$1.14M
2
AQR Capital Management
AQR Capital Management
Connecticut
+$581K
3
T. Rowe Price Investment Management
T. Rowe Price Investment Management
Maryland
+$422K
4
GCP
GSA Capital Partners
United Kingdom
+$352K
5
Susquehanna International Group
Susquehanna International Group
Pennsylvania
+$269K

Top Sellers

Rank Fund Capital Flow
1
AIM
ARK Investment Management
Florida
-$5.24M
2
WHG
Westwood Holdings Group
Texas
-$2.58M
3
Walleye Capital
Walleye Capital
New York
-$1.18M
4
N
Nuveen
North Carolina
-$850K
5
Bank of America
Bank of America
North Carolina
-$810K
Name Holding Trade Value Shares
Change 		Change in
Stake
AI
1
Alphabet Inc
California
$30M – – –
BlackRock
2
BlackRock
New York
$8.57M -$558K -218,573 -5%
T. Rowe Price Investment Management
3
T. Rowe Price Investment Management
Maryland
$8.24M +$422K +165,268 +4%
Fidelity Investments
4
Fidelity Investments
Massachusetts
$7.46M -$140K -54,793 -1%
Vanguard Group
5
Vanguard Group
Pennsylvania
$7.25M -$35.6K -13,969 -0.4%
AIM
6
ARK Investment Management
Florida
$6.16M -$5.24M -2,055,061 -40%
NAMA
7
Nikko Asset Management Americas
New York
$5.82M -$419K -164,157 -5%
Sumitomo Mitsui Trust Group
8
Sumitomo Mitsui Trust Group
Japan
$5.82M -$419K -164,157 -5%
RG
9
Redmile Group
California
$4.13M – – –
MM
10
MWG Management
British Virgin Islands
$3.57M – – –
Millennium Management
11
Millennium Management
New York
$3.54M -$241K -94,626 -5%
T. Rowe Price Associates
12
T. Rowe Price Associates
Maryland
$3.12M -$44.1K -17,284 -1%
Geode Capital Management
13
Geode Capital Management
Massachusetts
$3.04M +$150K +58,924 +4%
State Street
14
State Street
Massachusetts
$2.28M -$22.6K -8,876 -0.8%
BBA
15
Baker Bros. Advisors
New York
$2.05M – – –
GWM
16
Greenwich Wealth Management
Connecticut
$1.63M +$115K +45,000 +6%
FCM
17
Farallon Capital Management
California
$1.49M – – –
EC
18
EcoR1 Capital
California
$1.39M – – –
Northern Trust
19
Northern Trust
Illinois
$1.05M -$45K -17,628 -3%
Charles Schwab
20
Charles Schwab
California
$1M +$48.7K +19,106 +4%
MCM
21
Moore Capital Management
New York
$995K – – –
Renaissance Technologies
22
Renaissance Technologies
New York
$891K +$1.14M +447,600 New
SB
23
Samsara BioCapital
California
$806K – – –
CC
24
Casdin Capital
New York
$731K – – –
BG
25
Bollard Group
Massachusetts
$719K – – –
1
2 3 4 5

PRME Hedge Fund Activity: Q1 2025 in Review

125 of the 7,459 institutional investors tracked by Wall St. Rank reported a position in Prime Medicine (PRME) for Q1 2025, worth a combined $120M — down 36% from $188M a quarter earlier.

Sellers outnumbered buyers: 29 funds closed out of PRME and 22 opened new positions — a net loss of 7 holders — while 36 trimmed existing stakes and 41 added.

The largest buyer was Renaissance Technologies, opening a new position worth an estimated $1.14M. The largest seller was ARK Investment Management, cutting an estimated $5.24M.

  • 125 institutional investors held Prime Medicine (PRME) as of Q1 2025, down from 132 in Q4 2024.
  • Funds reported $120M of Prime Medicine stock for Q1 2025, down 36% quarter-over-quarter.
  • 22 funds opened new Prime Medicine positions in Q1 2025 and 29 closed out, a net change of -7 holders.
  • The largest Prime Medicine buyer in Q1 2025 was Renaissance Technologies, an estimated $1.14M added.
  • The largest Prime Medicine seller in Q1 2025 was ARK Investment Management, an estimated $5.24M sold.

Based on aggregated 13F filings for Q1 2025.