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Prime Medicine
PRME

Overview Fund Activity

123 hedge funds and large institutions have $120M invested in Prime Medicine in 2025 Q1 according to their latest regulatory filings, with 21 funds opening new positions, 41 increasing their positions, 35 reducing their positions, and 27 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
123
Holders Change
-7
Holders Change %
-5.38%
% of All Funds
1.67%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.01%
New
21
Increased
41
Reduced
35
Closed
27
Calls
$120K
Puts
$237K
Net Calls
-$117K
Net Calls Change
+$193K

Top Buyers

1
Renaissance Technologies
Renaissance Technologies
New York
+$891K
2
AQR Capital Management
AQR Capital Management
Connecticut
+$453K
3
T. Rowe Price Investment Management
T. Rowe Price Investment Management
Maryland
+$329K
4
GCP
GSA Capital Partners
United Kingdom
+$275K
5
Susquehanna International Group
Susquehanna International Group
Pennsylvania
+$210K

Top Sellers

1
AIM
ARK Investment Management
Florida
-$4.09M
2
WHG
Westwood Holdings Group
Texas
-$2.58M
3
Walleye Capital
Walleye Capital
New York
-$1.18M
4
Bank of America
Bank of America
North Carolina
-$632K
5
BlackRock
BlackRock
New York
-$435K
Name Holding Trade Value Shares
Change 		Shares
Change %
AI
1
Alphabet Inc
California
$30M – – –
BlackRock
2
BlackRock
New York
$8.57M -$435K -218,573 -5%
T. Rowe Price Investment Management
3
T. Rowe Price Investment Management
Maryland
$8.25M +$329K +165,268 +4%
Fidelity Investments
4
Fidelity Investments
Massachusetts
$7.46M -$109K -54,793 -1%
Vanguard Group
5
Vanguard Group
Pennsylvania
$7.25M -$27.8K -13,969 -0.4%
AIM
6
ARK Investment Management
Florida
$6.16M -$4.09M -2,055,061 -40%
NAMA
7
Nikko Asset Management Americas
New York
$5.82M -$327K -164,157 -5%
Sumitomo Mitsui Trust Group
8
Sumitomo Mitsui Trust Group
Japan
$5.82M -$327K -164,157 -5%
RG
9
Redmile Group
California
$4.13M – – –
MM
10
MWG Management
British Virgin Islands
$3.57M – – –
Millennium Management
11
Millennium Management
New York
$3.54M -$188K -94,626 -5%
T. Rowe Price Associates
12
T. Rowe Price Associates
Maryland
$3.12M -$34.4K -17,284 -1%
Geode Capital Management
13
Geode Capital Management
Massachusetts
$3.04M +$117K +58,924 +4%
State Street
14
State Street
Massachusetts
$2.28M -$17.7K -8,876 -0.8%
BBA
15
Baker Bros. Advisors
New York
$2.05M – – –
GWM
16
Greenwich Wealth Management
Connecticut
$1.63M +$89.6K +45,000 +6%
FCM
17
Farallon Capital Management
California
$1.49M – – –
EC
18
EcoR1 Capital
California
$1.39M – – –
Northern Trust
19
Northern Trust
Illinois
$1.05M -$35.1K -17,628 -3%
Charles Schwab
20
Charles Schwab
California
$1M +$38K +19,106 +4%
MCM
21
Moore Capital Management
New York
$995K – – –
Renaissance Technologies
22
Renaissance Technologies
New York
$891K +$891K +447,600 New
SB
23
Samsara BioCapital
California
$806K – – –
CC
24
Casdin Capital
New York
$731K – – –
BG
25
Bollard Group
Massachusetts
$719K – – –
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