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Prime Medicine
PRME

183 hedge funds and large institutions have $337M invested in Prime Medicine in 2025 Q4 according to their latest regulatory filings, with 44 funds opening new positions, 67 increasing their positions, 40 reducing their positions, and 26 closing their positions.

New
Increased
Maintained
Reduced
Closed

69% more first-time investments, than exits

New positions opened: 44 | Existing positions closed: 26

68% more repeat investments, than reductions

Existing positions increased: 67 | Existing positions reduced: 40

10% more funds holding

Funds holding: 167 → 183 (+16)

8% less call options, than puts

Call options by funds: $3.21M | Put options by funds: $3.5M

14.87% less ownership

Funds ownership: 68.62% → 53.75% (-15%)

34% less capital invested

Capital invested by funds: $512M → $337M (-$175M)

50% less funds holding in top 10

Funds holding in top 10: 2 → 1 (-1)

Holders
183
Holders Change
+16
Holders Change %
+9.58%
% of All Funds
2.23%
Holding in Top 10
1
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-50%
% of All Funds
0.01%
New
44
Increased
67
Reduced
40
Closed
26
Calls
$3.21M
Puts
$3.5M
Net Calls
-$295K
Net Calls Change
-$2.87M

Top Buyers

1
State Street
State Street
Massachusetts
+$16.9M
2
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$13.7M
3
BlackRock
BlackRock
New York
+$11.6M
4
UBS Group
UBS Group
Switzerland
+$9.5M
5
Vanguard Group
Vanguard Group
Pennsylvania
+$6.88M

Top Sellers

1
RCM
RA Capital Management
Massachusetts
-$16.6M
2
FCM
Farallon Capital Management
California
-$15.6M
3
T. Rowe Price Investment Management
T. Rowe Price Investment Management
Maryland
-$14.3M
4
EC
EcoR1 Capital
California
-$8.55M
5
Millennium Management
Millennium Management
New York
-$6.08M
Name Holding Trade Value Shares
Change 		Change in
Stake
AI
1
Alphabet Inc
California
$57.5M – – –
BlackRock
2
BlackRock
New York
$28.7M +$11.6M +2,617,984 +46%
Vanguard Group
3
Vanguard Group
Pennsylvania
$22.4M +$6.88M +1,546,007 +31%
T. Rowe Price Investment Management
4
T. Rowe Price Investment Management
Maryland
$20.8M -$14.3M -3,221,914 -35%
AIM
5
ARK Investment Management
Florida
$18.6M -$486K -109,325 -2%
State Street
6
State Street
Massachusetts
$17.7M +$16.9M +3,798,884 +293%
Sumitomo Mitsui Trust Group
7
Sumitomo Mitsui Trust Group
Japan
$11.3M -$1.71M -384,418 -11%
NAMA
8
Nikko Asset Management Americas
New York
$11.2M -$1.71M -384,418 -11%
CC
9
Casdin Capital
New York
$11M – – –
Balyasny Asset Management
10
Balyasny Asset Management
Illinois
$10.8M +$13.7M +3,076,489 +6,426%
WP
11
Woodline Partners
California
$10.4M +$1.61K +362 +0%
Geode Capital Management
12
Geode Capital Management
Massachusetts
$9.12M +$3.83M +861,533 +49%
UBS Group
13
UBS Group
Switzerland
$8.47M +$9.5M +2,135,810 +701%
Fidelity Investments
14
Fidelity Investments
Massachusetts
$7.55M -$2.83M -636,429 -23%
MCL
15
MWG Caph Ltd
$6.22M +$7.97M +1,792,210 New
Goldman Sachs
16
Goldman Sachs
New York
$6.09M +$5.98M +1,345,032 +327%
Two Sigma Investments
17
Two Sigma Investments
New York
$5.65M +$5.26M +1,181,657 +264%
D.E. Shaw & Co
18
D.E. Shaw & Co
New York
$5.38M -$2.96M -664,483 -30%
FCM
19
Farallon Capital Management
California
$4.31M -$15.6M -3,509,157 -74%
Susquehanna International Group
20
Susquehanna International Group
Pennsylvania
$4.08M +$2.63M +592,303 +101%
Morgan Stanley
21
Morgan Stanley
New York
$4.06M +$1.95M +438,894 +60%
Renaissance Technologies
22
Renaissance Technologies
New York
$3.99M +$64.4K +14,489 +1%
Charles Schwab
23
Charles Schwab
California
$3.25M +$1.62M +363,657 +63%
Northern Trust
24
Northern Trust
Illinois
$2.92M +$1.04M +234,164 +39%
GWM
25
Greenwich Wealth Management
Connecticut
$2.57M +$89K +20,000 +3%
1
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PRME Hedge Fund Activity: Q4 2025 in Review

183 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Prime Medicine (PRME) for Q4 2025, worth a combined $337M — down 34% from $512M a quarter earlier.

Buyers outnumbered sellers: 44 funds opened new PRME positions and 26 closed out — a net gain of 18 holders — while 67 added to existing stakes and 40 trimmed.

The largest buyer was State Street, adding an estimated $16.9M. The largest seller was RA Capital Management, exiting entirely with an estimated $16.6M sold.

  • 183 institutional investors held Prime Medicine (PRME) as of Q4 2025, up from 167 in Q3 2025.
  • Funds reported $337M of Prime Medicine stock for Q4 2025, down 34% quarter-over-quarter.
  • 44 funds opened new Prime Medicine positions in Q4 2025 and 26 closed out, a net change of +18 holders.
  • The largest Prime Medicine buyer in Q4 2025 was State Street, an estimated $16.9M added.
  • The largest Prime Medicine seller in Q4 2025 was RA Capital Management, an estimated $16.6M sold.

Based on aggregated 13F filings for Q4 2025.