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Disc Medicine
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Overview Fund Activity

150 hedge funds and large institutions have $1.8B invested in Disc Medicine in 2025 Q2 according to their latest regulatory filings, with 25 funds opening new positions, 69 increasing their positions, 36 reducing their positions, and 31 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
150
Holders Change
-7
Holders Change %
-4.46%
% of All Funds
2.01%
Holding in Top 10
9
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+12.5%
% of All Funds
0.12%
New
25
Increased
69
Reduced
36
Closed
31
Calls
$23.4M
Puts
$1.11M
Net Calls
+$22.3M
Net Calls Change
+$21M

Top Buyers

1
WP
Woodline Partners
California
+$19.3M
2
LGM
Logos Global Management
California
+$16.2M
3
FTM
First Turn Management
California
+$15.9M
4
BBA
Baker Bros. Advisors
New York
+$13.8M
5
SCM
Sio Capital Management
New York
+$11.2M

Top Sellers

1
Wellington Management Group
Wellington Management Group
Massachusetts
-$48.3M
2
BCLSI
Bain Capital Life Sciences Investors
Massachusetts
-$21.2M
3
SCM
Silverarc Capital Management
Massachusetts
-$11.7M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
-$10.9M
5
PA
Perceptive Advisors
New York
-$7.45M
Name Holding Trade Value Shares
Change 		Shares
Change %
AA
76
ALPS Advisors
Colorado
$986K -$363K -6,853 -27%
PCM
77
Prelude Capital Management
New York
$962K -$2.33K -44 -0.2%
New York State Common Retirement Fund
78
New York State Common Retirement Fund
New York
$892K +$560K +10,576 +169%
Invesco
79
Invesco
Georgia
$891K +$158K +2,983 +22%
Deutsche Bank
80
Deutsche Bank
Germany
$885K +$107K +2,012 +14%
Citigroup
81
Citigroup
New York
$853K -$1.42M -26,866 -63%
Mirae Asset Global ETFs Holdings
82
Mirae Asset Global ETFs Holdings
Hong Kong
$799K -$5.15K -97 -0.6%
MIM
83
MetLife Investment Management
New Jersey
$787K +$74.1K +1,400 +10%
HIS
84
Harvest Investment Services
Illinois
$758K -$56.5K -1,066 -7%
Walleye Capital
85
Walleye Capital
New York
$745K -$424K -8,011 -36%
AQR Capital Management
86
AQR Capital Management
Connecticut
$723K +$723K +13,649 New
State of Wisconsin Investment Board
87
State of Wisconsin Investment Board
Wisconsin
$683K +$48K +906 +8%
TRSOTSOK
88
Teachers Retirement System of the State of Kentucky
Kentucky
$681K -$94.2K -1,777 -12%
UOC
89
UBS O'Connor
Illinois
$652K -$69.1K -1,304 -10%
IIM
90
INTECH Investment Management
Florida
$647K +$67.5K +1,274 +12%
Bank of Montreal
91
Bank of Montreal
Ontario, Canada
$582K +$272K +5,137 +88%
LPC
92
Lion Point Capital
New York
$561K – – –
First Trust Advisors
93
First Trust Advisors
Illinois
$543K +$543K +10,246 New
YIH
94
Y-Intercept (HK)
Hong Kong
$497K +$497K +9,382 New
State Board of Administration of Florida Retirement System
95
State Board of Administration of Florida Retirement System
Florida
$483K +$269K +5,079 +125%
Universal-Beteiligungs- und Servicegesellschaft
96
Universal-Beteiligungs- und Servicegesellschaft
Germany
$391K +$52.2K +985 +15%
SI
97
Sofinnova Investments
California
$387K -$9.16K -173 -2%
LCM
98
Legato Capital Management
California
$383K +$383K +7,228 New
CUAMC
99
China Universal Asset Management Company
China
$368K +$1.17K +22 +0.3%
HS
100
HighVista Strategies
Massachusetts
$357K +$14.6K +275 +4%
2 3
4
5 6