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Disc Medicine
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Overview Fund Activity

157 hedge funds and large institutions have $1.65B invested in Disc Medicine in 2025 Q1 according to their latest regulatory filings, with 27 funds opening new positions, 74 increasing their positions, 31 reducing their positions, and 21 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
157
Holders Change
+5
Holders Change %
+3.29%
% of All Funds
2.13%
Holding in Top 10
8
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.11%
New
27
Increased
74
Reduced
31
Closed
21
Calls
$1.6M
Puts
$333K
Net Calls
+$1.27M
Net Calls Change
-$188K

Top Buyers

1
RCM
RA Capital Management
Massachusetts
+$78.3M
2
Fidelity Investments
Fidelity Investments
Massachusetts
+$67.4M
3
SL
Siren LLC
Connecticut
+$53.2M
4
Wellington Management Group
Wellington Management Group
Massachusetts
+$47.1M
5
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
+$34.7M

Top Sellers

1
Citadel Advisors
Citadel Advisors
Florida
-$26.3M
2
MB
MPM BioImpact
Massachusetts
-$22M
3
O
OrbiMed
New York
-$18.4M
4
PBA
Paradigm Biocapital Advisors
New York
-$14.2M
5
CCM
Catalio Capital Management
New York
-$11.4M
Name Holding Trade Value Shares
Change 		Shares
Change %
SCM
26
Silverarc Capital Management
Massachusetts
$11.7M +$6.26M +126,090 +114%
D.E. Shaw & Co
27
D.E. Shaw & Co
New York
$10.9M +$6.87M +138,413 +170%
Northern Trust
28
Northern Trust
Illinois
$10.4M +$1.08M +21,796 +12%
Charles Schwab
29
Charles Schwab
California
$9.67M +$1.47M +29,653 +18%
Victory Capital Management
30
Victory Capital Management
Texas
$9.61M -$2.11M -42,580 -18%
Renaissance Technologies
31
Renaissance Technologies
New York
$9.49M +$5.2M +104,800 +121%
EAM
32
Eventide Asset Management
Massachusetts
$9.03M +$9.03M +181,818 New
Morgan Stanley
33
Morgan Stanley
New York
$8.45M +$1M +20,186 +13%
PA
34
Perceptive Advisors
New York
$7.45M +$7.45M +150,000 New
NCM
35
Nantahala Capital Management
Connecticut
$7.37M -$79.9K -1,609 -1%
BOCH
36
Blue Owl Capital Holdings
New York
$6.96M +$993K +20,000 +17%
Dimensional Fund Advisors
37
Dimensional Fund Advisors
Texas
$6.92M -$16.2K -327 -0.2%
Goldman Sachs
38
Goldman Sachs
New York
$6.49M -$2.04M -41,059 -24%
Pictet Asset Management
39
Pictet Asset Management
Switzerland
$6.47M +$44.9K +904 +0.7%
NL
40
Nuveen LLC
North Carolina
$5.6M +$5.6M +112,717 New
Millennium Management
41
Millennium Management
New York
$5.39M +$4.99M +100,620 +1,277%
UBS AM
42
UBS AM
Illinois
$4.79M +$171K +3,454 +4%
Schroder Investment Management Group
43
Schroder Investment Management Group
United Kingdom
$4.57M -$220K -4,200 -5%
OM
44
Opaleye Management
Massachusetts
$4.22M +$4.22M +85,000 New
Raymond James Financial
45
Raymond James Financial
Florida
$4.13M -$235K -4,726 -5%
PSC
46
Patient Square Capital
California
$4.12M +$1.32M +26,600 +47%
SCM
47
Suvretta Capital Management
New York
$3.97M +$3.97M +80,000 New
BBA
48
Baker Bros. Advisors
New York
$3.82M – – –
SCM
49
Sio Capital Management
New York
$3.65M – – –
UBS Group
50
UBS Group
Switzerland
$3.61M +$2.4M +48,286 +198%
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