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Disc Medicine
IRON

157 hedge funds and large institutions have $1.65B invested in Disc Medicine in 2025 Q1 according to their latest regulatory filings, with 26 funds opening new positions, 75 increasing their positions, 31 reducing their positions, and 21 closing their positions.

New
Increased
Maintained
Reduced
Closed

381% more call options, than puts

Call options by funds: $1.6M | Put options by funds: $333K

142% more repeat investments, than reductions

Existing positions increased: 75 | Existing positions reduced: 31

24% more first-time investments, than exits

New positions opened: 26 | Existing positions closed: 21

6.6% more ownership

Funds ownership: 89.3% → 95.9% (+6.6%)

3% more funds holding

Funds holding: 152 → 157 (+5)

0% more funds holding in top 10

Funds holding in top 10: 8 → 8 (0)

2% less capital invested

Capital invested by funds: $1.68B → $1.65B (-$34.9M)

Holders
157
Holders Change
+5
Holders Change %
+3.29%
% of All Funds
2.1%
Holding in Top 10
8
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.11%
New
26
Increased
75
Reduced
31
Closed
21
Calls
$1.6M
Puts
$333K
Net Calls
+$1.27M
Net Calls Change
-$188K

Top Buyers

Rank Fund Capital Flow
1
RCM
RA Capital Management
Massachusetts
+$87.7M
2
Fidelity Investments
Fidelity Investments
Massachusetts
+$75.5M
3
SL
Siren LLC
Connecticut
+$59.6M
4
Wellington Management Group
Wellington Management Group
Massachusetts
+$52.7M
5
JP Morgan Chase
JP Morgan Chase
New York
+$38.8M

Top Sellers

Rank Fund Capital Flow
1
Citadel Advisors
Citadel Advisors
Florida
-$29.4M
2
MB
MPM BioImpact
Massachusetts
-$22M
3
O
OrbiMed
New York
-$20.6M
4
PBA
Paradigm Biocapital Advisors
New York
-$15.9M
5
CCM
Catalio Capital Management
New York
-$11.4M
Name Holding Trade Value Shares
Change 		Change in
Stake
SCM
26
Silverarc Capital Management
Massachusetts
$11.7M +$7.01M +126,090 +114%
D.E. Shaw & Co
27
D.E. Shaw & Co
New York
$10.9M +$7.7M +138,413 +170%
Northern Trust
28
Northern Trust
Illinois
$10.4M +$1.21M +21,796 +12%
Charles Schwab
29
Charles Schwab
California
$9.67M +$1.65M +29,653 +18%
Victory Capital Management
30
Victory Capital Management
Texas
$9.61M -$2.37M -42,580 -18%
Renaissance Technologies
31
Renaissance Technologies
New York
$9.49M +$5.83M +104,800 +121%
EAM
32
Eventide Asset Management
Massachusetts
$9.03M +$10.1M +181,818 New
Morgan Stanley
33
Morgan Stanley
New York
$8.45M +$1.12M +20,186 +13%
PA
34
Perceptive Advisors
New York
$7.45M +$8.34M +150,000 New
NCM
35
Nantahala Capital Management
Connecticut
$7.37M -$89.5K -1,609 -1%
BOCH
36
Blue Owl Capital Holdings
New York
$6.96M +$1.11M +20,000 +17%
Dimensional Fund Advisors
37
Dimensional Fund Advisors
Texas
$6.92M -$18.2K -327 -0.2%
Goldman Sachs
38
Goldman Sachs
New York
$6.49M -$2.28M -41,059 -24%
Pictet Asset Management
39
Pictet Asset Management
Switzerland
$6.47M +$50.3K +904 +0.7%
N
40
Nuveen
North Carolina
$5.6M +$3.48M +62,596 +125%
Millennium Management
41
Millennium Management
New York
$5.39M +$5.59M +100,620 +1,277%
UBS AM
42
UBS AM
Illinois
$4.79M +$192K +3,454 +4%
Schroder Investment Management Group
43
Schroder Investment Management Group
United Kingdom
$4.57M -$234K -4,200 -5%
OM
44
Opaleye Management
Massachusetts
$4.22M +$4.73M +85,000 New
Raymond James Financial
45
Raymond James Financial
Florida
$4.13M -$263K -4,726 -5%
PSC
46
Patient Square Capital
California
$4.12M +$1.48M +26,600 +47%
SCM
47
Suvretta Capital Management
New York
$3.97M +$4.45M +80,000 New
BBA
48
Baker Bros. Advisors
New York
$3.82M – – –
SCM
49
Sio Capital Management
New York
$3.65M – – –
UBS Group
50
UBS Group
Switzerland
$3.61M +$2.68M +48,286 +198%
1
2
3 4 5

IRON Hedge Fund Activity: Q1 2025 in Review

157 of the 7,459 institutional investors tracked by Wall St. Rank reported a position in Disc Medicine (IRON) for Q1 2025, worth a combined $1.65B — down 2.1% from $1.68B a quarter earlier.

Buyers outnumbered sellers: 26 funds opened new IRON positions and 21 closed out — a net gain of 5 holders — while 75 added to existing stakes and 31 trimmed.

The largest buyer was RA Capital Management, opening a new position worth an estimated $87.7M. The largest seller was Citadel Advisors, cutting an estimated $29.4M.

  • 157 institutional investors held Disc Medicine (IRON) as of Q1 2025, up from 152 in Q4 2024.
  • Funds reported $1.65B of Disc Medicine stock for Q1 2025, down 2.1% quarter-over-quarter.
  • 26 funds opened new Disc Medicine positions in Q1 2025 and 21 closed out, a net change of +5 holders.
  • The largest Disc Medicine buyer in Q1 2025 was RA Capital Management, an estimated $87.7M added.
  • The largest Disc Medicine seller in Q1 2025 was Citadel Advisors, an estimated $29.4M sold.

Based on aggregated 13F filings for Q1 2025.